Progetto senza titolo

Il progetto in questione derivava da ricerche e letture degli artisti sui Test di Turing. Due computer settati con conoscenze di base complementari rispondevano agli input visivi che il visitatore mostrava ad uno dei due, il primo computer processava lʼimmagine comunicandola poi verbalmente al secondo computer, cioè il primo computer parlava al secondo descrivendogli lʼimmagine. Il secondo computer, basandosi sulle informazioni presenti in memoria, attivava un processo di raffigurazione della descrizione che poi rappresentava tramite un videoproiettore a fianco all'immagine che era stata mostrata al primo computer. Le due immagini venivano infine esposte fianco a fianco, mostrando così il processo di traduzione immagine>parola>immagine. Il progetto aveva bisogno di un numero elevato di collaborazioni tecnico-scientifiche per rendere possibile la trasmissione dati. Tuttavia il suo nucleo concettuale prende vita in due performance che gli artisti realizzano nel 2011 e 2014.This project derives from the artistsʼ research around the Turing Test. Two computers set up with basic complementary knowledge responded to the visual inputs that the visitor showed to one of them: the first computer processed the image and then verbally communicated it to the second computer, in fact the first computer spoke to the second describing the image. The second computer, on the basis of information stored in its memory, activated a process of representation of the description, which it then actually represented through a projector next to the image that had been shown to the first computer. The two images were finally exposed side by side, showing the translation process image> word> image. The project needed a great number of technical and scientific partnerships to make the data transmission possible. However, the concept behind the project came to life with two performances the artists realized in 2011 and 2014

Improvements of simplified hourly models for the energy assessment of buildings: The application of EN ISO 52016 in Italy

The Italian National Annex (NA) to EN ISO 52016-1 is aimed at improving the simplified hourly calculation method of the building thermal performance assessment by introducing different modelling options. The present work deepens the influence of the Italian NA improved method on the thermal energy needs for heating and cooling of a residential building-type in two different climate zones. In particular, the Italian NA improved options are applied one-at-the-time, and their effect is evaluated in comparison with the EN ISO 52016-1 standard method. The use of solar angle and time dependent correction factors for the total solar energy transmittance of glazing proved to be the most sensitive modelling option, among those analysed. Negligible variations were instead reported for the other tested options

Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats.

BACKGROUND: We considered of interest to evaluate how aging affects mitochondrial function in skeletal muscle. METHODS: We measured mitochondrial oxidative capacity and proton leak, together with lipid oxidative damage, superoxide dismutase specific activity and uncoupling protein 3 content, in subsarcolemmal and intermyofibrillar mitochondria from adult (six months) and old (two years) rats. Body composition, resting metabolic rate and plasma non esterified fatty acid levels were also assessed. RESULTS: Old rats displayed significantly higher body energy and lipids, while body proteins were significantly lower, compared to adult rats. In addition, plasma non esterified fatty acid levels were significantly higher, while resting metabolic rates were found to be significantly lower, in old rats compared to adult ones. Significantly lower oxidative capacities in whole tissue homogenates and in intermyofibrillar and subsarcolemmal mitochondria were found in old rats compared to adult ones. Subsarcolemmal and intermyofibrillar mitochondria from old rats exhibited a significantly lower proton leak rate, while oxidative damage was found to be significantly higher only in subsarcolemmal mitochondria. Mitochondrial superoxide dismutase specific activity was not significantly affected in old rats, while significantly higher content of uncoupling protein 3 was found in both mitochondrial populations from old rats compared to adult ones, although the magnitude of the increase was lower in subsarcolemmal than in intermyofibrillar mitochondria. CONCLUSIONS: The decrease in oxidative capacity and proton leak in intermyofibrillar and subsarcolemmal mitochondria could induce a decline in energy expenditure and thus contribute to the reduced resting metabolic rate found in old rats, while oxidative damage is present only in subsarcolemmal mitochondria

Mitochondrial efficiency and insulin resistance

Insulin resistance, “a relative impairment in the ability of insulin to exert its effects on glucose, protein and lipid metabolism in target tissues,” has many detrimental effects on metabolism and is strongly correlated to deposition of lipids in non-adipose tissues. Mitochondria are the main cellular sites devoted to ATP production and fatty acid oxidation. Therefore, a role for mitochondrial dysfunction in the onset of skeletal muscle insulin resistance has been proposed and many studies have dealt with possible alteration in mitochondrial function in obesity and diabetes, both in humans and animal models. Data reporting evidence of mitochondrial dysfunction in type two diabetes mellitus are numerous, even though the issue that this reduced mitochondrial function is causal in the development of the disease is not yet solved, also because a variety of parameters have been used in the studies carried out on this subject. By assessing the alterations in mitochondrial efficiency as well as the impact of this parameter on metabolic homeostasis of skeletal muscle cells, we have obtained results that allow us to suggest that an increase in mitochondrial efficiency precedes and therefore can contribute to the development of high-fat-induced insulin resistance in skeletal muscle

A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance

Mitochondria are the main cellular sites devoted to ATP production and lipid oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of cellular fate of circulating lipids, that accumulate in the cytoplasm, if they are not oxidized. The ectopic fat accumulation is associated with the development of insulin resistance, and a link between mitochondrial dysfunction and insulin resistance has been proposed

Eco-friendly gas mixtures for Resistive Plate Chambers based on Tetrafluoropropene and Helium

Due to the recent restrictions deriving from the application of the Kyoto protocol, the main components of the gas mixtures presently used in the Resistive Plate Chambers systems of the LHC experiments will be most probably phased out of production in the coming years. Identifying possible replacements with the adequate characteristics requires an intense R&D, which was recently started, also in collaborations across the various experiments. Possible candidates have been proposed and are thoroughly investigated. Some tests on one of the most promising candidate - HFO-1234ze, an allotropic form of tetrafluoropropane- have already been reported. Here an innovative approach, based on the use of Helium, to solve the problems related to the too elevate operating voltage of HFO-1234ze based gas mixtures, is discussed and the relative first results are shown.Comment: 9 pages, 6 figures, 1 tabl

HP-LT metamorphism in Elba Island: Implications for the geodynamic evolution of the inner Northern Apennines (Italy)

The inner Northern Apennines belt (i.e., northern Tyrrhenian Sea and Tuscany) is an Alpine chain affectedby high-P metamorphic conditions during its evolution. Although Elba Island is structurally located closeto the Adria-Europe suture zone, for several authors it represents a sector of the orogen affected bylow-P metamorphism. The involvement of Elba Island tectonic units in high-P metamorphism was onlysuspected for the sparse presence of phengitic white mica in the metasedimentary rocks. This paperpresents the first clear evidence of high-P and low-T metamorphism found in metabasite rocks embed-ded in the Cretaceous calcschist of eastern Elba Island. Mineral composition of metabasite includesGln + Cpx + Ep + Ab + Act + Qtz + Ilm ± Ti-oxide ± Spn and is indicative of a former equilibration in the epi-dote blueschist subfacies and subsequent retrogression in the greenschist facies. Recorded metamorphicconditions are P = 0.9–1.0 GPa and T = 330–350◦C. Tectonic discrimination using immobile elements inthe metabasite does not point to an oceanic setting. As a consequence, the metasedimentary succes-sion containing metabasite is explained as belonging to the Tuscan continental domain and not to theLigurian-Piedmont Ocean, as previously interpreted. Our results have two significant implications: (i)it is confirmed and strengthened that the tectonic stacking of the Elba Island units did not occur in alow-pressure context; (ii) Elba Island is now completely reconciled in the tectonic and metamorphicevolution of the inner Northern Apennines