Legislative Documents

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Additional file 6: of Gut microbiota in experimental murine model of Graves’ orbitopathy established in different environments may modulate clinical presentation of disease

Figure S1. NMDS plot based on the weighted Unifrac distances of Center2 immune and control mice including TSHR-immunized mice from Center 1. TSHR-immunized mice from Center 1 were more similar to TSHR-immunized mice from Center 2 (P = 0.2) than to the βgal (P = 0.024) than the untreated (P = 0.04). (PDF 28 kb

Additional file 2: of Gut microbiota in experimental murine model of Graves’ orbitopathy established in different environments may modulate clinical presentation of disease

Supplementary methods. (DOCX 121 kb

Additional file 3: of Gut microbiota in experimental murine model of Graves’ orbitopathy established in different environments may modulate clinical presentation of disease

Table S1. Differential abundant taxonomic analysis between TSHR (n = 10), βgal (n = 8), and untreated (n = 6), within Center 2. Welch’s T-test with 95% confidence interval using STAMP. Mean relative frequency, rel. freq. Standard deviation, std. dev. Table S2. Comparison of intestinal scraped samples from different immunization within Center 2 from the traditional microbiological culture. Data were Box-Cox transformed. (XLSX 43 kb

Additional file 1: of Gut microbiota in experimental murine model of Graves’ orbitopathy established in different environments may modulate clinical presentation of disease

Figure S1. Schematic representation of the GO immunization protocol and sample collection. Table S1. Summary of disease characteristics induced in mice in Center 1 and Center 2 using TSHR expression plasmid illustrating the heterogeneity of response. Table S2. Quarterly Health Screen Reports on viral, bacterial, mycoplasma and parasite screen in both centers. Table S3. Composition of the commercial chows provided ad libitum in Center 1 and Center 2. (DOCX 106 kb