Production of Aruana Guinea Grass Submitted to Cutting Severities and Nitrogen Fertilization

Aruana Guineagrass (Panicum maximum Jacques cv. Aruana) is widely used as pasture for sheep, which are extremely susceptible to infestation by larvae of gastrointestinal parasites in tropical pasture-based systems (Zanini et al. 2012) A way to mitigate this problem, and consequently reduce the need for use of anthelmintics, is by managing pastures with post-grazing height low enough to favor the incidence of sunlight at the base of tussocks that will kill and control larval development, without jeopardizing canopy regrowth and persistence. The pre-grazing sward height recommended for Aruana Guineagrass is 30 cm, when the canopy intercepts 95% of the incident light, and a 15 cm post-grazing height (Zanini et al. 2012). As cutting severity and nitrogen (N) fertilization cause morphological and physiological adaptations in individual plants - altering the production of forage grasses - the objective of this study was to evaluate the accumulation of morphological components of Aruana Guineagrass subjected to cutting severities and N fertilization

C7a, a Biphosphinic Cyclopalladated Compound, Efficiently Controls the Development of a Patient-Derived Xenograft Model of Adult T Cell Leukemia/Lymphoma

Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive disease that occurs in individuals infected with the human T lymphotropic virus type 1 (HTLV-1). Patients with aggressive ATLL have a poor prognosis because the leukemic cells are resistant to conventional chemotherapy. We have investigated the therapeutic efficacy of a biphosphinic cyclopalladated complex {Pd2 [S(−)C2, N-dmpa]2 (μ-dppe)Cl2}, termed C7a, in a patient-derived xenograft model of ATLL, and investigated the mechanism of C7a action in HTLV-1-positive and negative transformed T cell lines in vitro. In vivo survival studies in immunocompromised mice inoculated with human RV-ATL cells and intraperitoneally treated with C7a led to significantly increased survival of the treated mice. We investigated the mechanism of C7a activity in vitro and found that it induced mitochondrial release of cytochrome c, caspase activation, nuclear condensation and DNA degradation. These results suggest that C7a triggers apoptotic cell death in both HTLV-1 infected and uninfected human transformed T-cell lines. Significantly, C7a was not cytotoxic to peripheral blood mononuclear cells (PBMC) from healthy donors and HTLV-1-infected individuals. C7a inhibited more than 60% of the ex vivo spontaneous proliferation of PBMC from HTLV-1-infected individuals. These results support a potential therapeutic role for C7a in both ATLL and HTLV-1-negative T-cell lymphomas

Nursing Diagnosis in Patients with Liver Cirrhosis in Use of Feeding Tube

Abstract The objective was to identify the most frequent nursing diagnoses labels in patients with liver cirrhosis in use of feeding tube. A descriptive research was carried out in a Brazilian Hospital with 20 adult patients. Systematic data collection utilized the Conceptual Model of Wanda Horta, the first nurse to introduce the concept of Nursing Process in Brazil. The six phases of the nursing diagnostic reasoning proposed by Risner were used; nursing diagnoses were described according to NANDA-I taxonomy II. Patients were mainly male; half of them were middle age adults; they had an average of 12.8 nursing diagnoses labels; and the most frequent were: risk for aspiration and risk for infection. Nurses needed to develop effective skills to properly diagnose in order to provide safe care and improve patient outcomes