Brussels blog round up for 17– 23 November: Budget troubles, France is downgraded, and are European young farmers facing extinction?

Chris Gilson and Stuart A Brown take a look at the week in Brussels blogging

A new species of Anadia (Reptilia, Squamata) from the Venezuelan 'Lost World', northern South America

A new gymnophthalmid lizard of the genus Anadia Gray, 1845 is described from the summit of Abakapá-tepui, Bolívar State, Venezuela, between 2200-2242 m elevation. The new species, Anadia mcdiarmidi sp. nov., is endemic to the Chimantá Massif and seemingly also occurs on Amurí-tepui and Murei-tepui. The new taxon is mainly distinguished from all known congeners by the following combination of characters: body fairly robust, dorsal scales small and quadrangular, middorsal scales 53-57, suboculars large, subequal in size, with sometimes one scale slightly protruding downward between 4th and 5th supralabial, nasal entire, without sub-nostril groove, body uniform beige or greyish to bluish brown in life, devoid of any conspicuous pattern in males, venter immaculate golden grey in life, femoral pores 9-10 on each side in males, preanal pores absent, hemipenis globose, weakly bilobed, bordered by numerous fl ounces (>20) bearing comblike rows of minute weakly mineralized spinules. The presence of a species of Anadia, a primarily Andean genus, on the top of tepuis is of considerable interest to the understanding of the Pantepui biogeography

A direct approach to the ultradiscrete KdV equation with negative

A generalisation of the ultra-discrete KdV equation is investigated using a direct approach. We show that evolution through one time step serves to reveal the entire solitonic content of the system

Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study.

Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy. We explored residual viremia and systemic inflammation markers in patients effectively treated with ritonavir-boosted protease inhibitor monotherapy (PImono)

Tunable pinning of a superconducting vortex a by a magnetic vortex

The interaction between a straight vortex line in a superconducting film and a soft magnetic nanodisk in the magnetic vortex state in the presence of a magnetic field applied parallel to the film surfaces is studied theoretically. The superconductor is described by London theory and the nanodisk by the Landau-Lifshitz continuum theory of magnetism, using the approximation known as the rigid vortex model. Pinning of the vortex line by the nanodisk is found to result, predominantly, from the interaction between the vortex line and the changes in the nanodisk magnetization induced by the magnetic field of the vortex line and applied field. In the context of the rigid vortex model, these changes result from the displacement of the magnetic vortex. This displacement is calculated analytically by minimizing the energy, and the pinning potential is obtained. The applied field can tune the pinning potential by controlling the displacement of the magnetic vortex. The nanodisk magnetization curve is predicted to change in the presence of the vortex lineComment: 9 pages, 8 figures. Submitted to Phys. Rev.

Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection

Liver-related mortality is an increasing problem in human immunodeficiency virus (HIV)/hepatitis B virus (HBV)-coinfected patients receiving highly active antiretroviral therapy (HAART). In HIV-negative patients, HBV chronicity is associated with a reduction in specific T cell responses that can be partially restored by treatment with lamivudine. We studied 5 HIV/HBV-coinfected patients treated with HAART, either with or without addition of a drug with specific anti-HBV activity. Our data show that reconstitution of some HBV-specific T cell responses can also occur in HIV-positive patients after a reduction in HBV load. This potential to recover T cell responses, which has been thought to be critical for HBV control, provides support for the addition of anti-HBV therapy in the treatment of HIV/HBV-coinfected patients

Curiosities of REPINs and RAYTs

Repetitive extragenic palindromic (REP) sequences are a ubiquitous feature of bacterial genomes. Recent work shows that REPs are remnants of a larger mobile genetic element termed a REPIN. REPINs consists of two REP sequences in inverted orientation separated by a spacer region and are thought to be non-autonomous mobile genetic elements that exploit the transposase encoded by REP-Associated tYrosine Transposases (RAYTs). Complimentarity between the two ends of the REPIN suggests that the element forms hairpin structures in single stranded DNA or RNA. In addition to REPINs, other more complex arrangements of REPs have been identified in bacterial genomes, including the genome of the model organism Pseudomonas fluorescens SBW25. Here, we summarize existing knowledge and present new data concerning REPIN diversity. We also consider factors affecting the evolution of REPIN diversity, the ease with which REPINs might be co-opted by host genomes and the consequences of REPIN activity for the structure of bacterial genomes