An Investigation With Observations on the Complications of Scarlet Fever in Three Series of Cases Treated Under Different Conditions of Isolation, With Special Regard to the Increase in the Isolation Period, Caused by Such Complications

Abstract Not Provided

The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias

Tefinostat (CHR-2845) is a novel monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor which is cleaved into its active acid by the intracellular esterase human carboxylesterase-1 (hCE-1). The in vitro efficacy of tefinostat was characterised in cell lines and in a cohort of 73 primary AML and CMML samples. Dose-dependent induction of apoptosis and significant growth inhibitory effects were seen in myelomonocytic (M4), monocytic/monoblastic (M5) and CMML samples in comparison to non-monocytoid AML sub-types (p = 0.007). Importantly, no growth inhibitory effects were seen in normal bone marrow CD34+ cells exposed to AML-toxic doses of tefinostat in clonogenic assays. Expression of hCE-1 was measured by intracellular flow cytometry and immunoblotting across the cohort, with highest levels seen in M5 AML patients. hCE-1 levels correlated with significantly increased tefinostat sensitivity (low EC50) as measured by growth inhibition assays (p = 0.001)and concomitant elevation of the mature monocytoid marker CD14+. Strong induction of intracellular histone protein acetylation was observed in tefinostat-responsive samples, as were high levels of the DNA damage sensor γ-H2A.X, highlighting potential biomarkers of patient responsiveness. Synergistic interaction between tefinostat and the current standard treatment cytarabine was demonstrated in dose response and clonogenic assays using simultaneous drug addition in primary samples (median Combination Index value = 0.51). These data provide a strong rationale for the further clinical evaluation of tefinostat in monocytoid-lineage haematological neoplasms including CMML and monocyte-lineage AMLs

The Undergraduate preparation of dentists: Confidence levels of final year dental students at the School of Dentistry in Cardiff

Objective To investigate the self-reported confidence and preparedness of final year undergraduate students in undertaking a range of clinical procedures. Methods A questionnaire was distributed to final year dental students at Cardiff University, six months prior to graduation. Respondents rated their confidence in undertaking 39 clinical procedures using a 5-point scale (1 = can undertake on own with confidence, 5 = unable to undertake). Students also responded yes/no to experiencing four difficulties and to three statements about general preparedness. Results 71% (N = 51) responded of which 55% (N = 28) were female. Over half reported being 'anxious that the supervisor was not helping enough' (57%) and 'relying heavily on supervisor for help' (53%). Eighty percent 'felt unprepared for the clinical work presented' and gender differences were most notable here (male: 65% N = 33; females: 93% N = 47). Mean confidence scores were calculated for each clinical procedure (1 = lowest; 5 = highest). Confidence was highest in performing 'simple scale' and 'fissure sealant' (mean-score = 5). Lowest scores were reported for 'surgical extractions involving a flap (mean-score = 2.28)', 'simple surgical procedures' (mean-score = 2.58) and the 'design/fit/adjustment of orthodontic appliances' (mean-score = 2.88). Conclusions As expected complex procedures that were least practised scored the lowest in overall mean confidence. Gender differences were noted in self-reported confidence for carrying out treatment unsupervised and feeling unprepared for clinical work

Effect of alloy type and casting technique on the fracture strength of implant-cemented structures

Objectives: To evaluate the influence of alloy type and casting procedure on the fracture strength (FS) of metallic frameworks for implant-supported fixed prostheses. Study design: Thirty three-unit structures for lower posterior bridges were waxed-up and randomly assigned to two groups (n=15) according to alloy type and casting technique: Group 1 (C): cobalt-chromium cast in a centrifugal machine (TS1, Degussa-Hüls); Group 2 (T): titanium cast in a pressure-differential device (Cyclarc II, Morita). Each structure was cemented onto two prefabricated abutments under a constant seating pressure. After 6 months of water aging, samples were loaded in a static universal testing machine (EFH/5/FR, Microtest) until fracture. Axial compressive loads were applied at the central fossa of the pontics. FS data were recorded and surface topography of the fractured connectors was SEM-analyzed. A Chi-Square test was performed to assess the dependence of pores on the alloy type and casting procedure. ANOVA and Student-Newman-Keuls (SNK) tests were run for FS comparisons (p<0.05). Results: One third of the C structures showed pores inside the fractured connectors. T frameworks demonstrated higher FS than that of C specimens exhibiting pores (p=0.025). C samples containing no pores recorded the greatest mean FS (p<0.001). Conclusions: Fracture strength of metallic frameworks depended on the alloy type and casting procedure. Cobalt-chromium casts often registered pores inside the connectors, which strongly decreased the fracture resistance. An accurate casting of titanium with a pressure-differential system may result in the most predictable technique under the tested experimental conditions. © Medicina Oral S. L

(4-Hydr­oxy-2,5-dimethyl­phen­yl)phenyl­methanone

The title compound, C15H14O2, was obtained by Friedel–Crafts acyl­ation between 2,5-dimethyl­phenol and benzoyl chloride in the presence of aluminium chloride as a catalyst. The dihedral angle between the benzene rings is 61.95 (4)°. In the crystal, O—H⋯O hydrogen bonding and C—H⋯O weak inter­actions lead to polymeric C(6), C(8) and C(11) chains along the a, b and c-axis directions, respectively

Clinical skills of a new foundation dentist: the expectations of dental foundation educational supervisors

Aim To investigate dental foundation (DF) educational supervisors' (ES) expectations of the level of clinical ability expected of a foundation dentist (FD) on entry into foundation training. Methods Following ethical approval, a pre-piloted online questionnaire was circulated to ESs across England and Northern Ireland (n = 959), requiring respondents to rate their expectations of their FDs' ability at the beginning of the training year, in relation to undertaking 104 clinical skills. A five-point scale and descriptors were provided, ranging from 'on own with confidence' to 'unable to undertake'. Respondents were invited to comment further. Data were imported into IBM SPSS (v20) and descriptive analysis was undertaken. Expectations were assigned values and a mean, 'skill rank score' was generated for each skill. A ranking score closer to five indicated high expectation; closer to one indicated low expectation. Results A total of 510 (53%) questionnaires were completed. The study highlighted a range of expectations which were used to identify 'upper-level' (core) skills expected of a new FD. The majority of expectations were in line with UG curriculum guidance; however, certain skills were identified as having overly high expectations and these may need to be modified to align with current guidance. Conclusions Understanding the expectations ESs have of a new FD is useful for both dental schools and those involved in DF training. Findings add to the existing evidence base and should generate discussion for those within the education continuum to enhance the successful development of the FD

The Ursinus Weekly, October 24, 1974

Profs to lecture on Pa. Dutch arts • Dr. Lodge joins U.C. Psych Dept. • Campus Chest plans for funds and fun • Forum features flute and guitar • Is there a ghost in U.C.\u27s haunted hall? • Letters to the editor: Students demand a good education • The origin of The Lantern • Alumni corner • An autumn walk • Mr. Richter goes to school • What\u27s playing at the movies? • Spectrum blues: Joe Cocker • Spanish Club plans outing • Campus Gold activities • Introducing campus leaders • Money given away • Ursinus Homecoming 1974: Fraternity candidates to wear the queen\u27s crown • Homecoming from Ursinus past • Union ripped-off • A football commentary • X-country: three in a rowhttps://digitalcommons.ursinus.edu/weekly/1023/thumbnail.jp