കേരളം സമുദ്ര മത്സ്യബന്ധന നിയന്ത്രണ ചട്ടം 2018 കേരളം സർക്കാരിന്റെ ഫിഷറീസ് & തുറമുഖ (ബി) വകുപ്പ് പുറത്തിറക്കിയ വിജ്ഞാപനത്തിന്റെ വിവർത്തനം

കേരളം സമുദ്ര മത്സ്യബന്ധന നിയന്ത്രണ ചട്ടം 2018 കേരളം സർക്കാരിന്റെ ഫിഷറീസ് & തുറമുഖ (ബി) വകുപ്പ് പുറത്തിറക്കിയ വിജ്ഞാപനത്തിന്റെ വിവർത്തന

Restricted feedback control of one-dimensional maps

Dynamical control of biological systems is often restricted by the practical constraint of unidirectional parameter perturbations. We show that such a restriction introduces surprising complexity to the stability of one-dimensional map systems and can actually improve controllability. We present experimental cardiac control results that support these analyses. Finally, we develop new control algorithms that exploit the structure of the restricted-control stability zones to automatically adapt the control feedback parameter and thereby achieve improved robustness to noise and drifting system parameters.Comment: 29 pages, 9 embedded figure

Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations

<p>Abstract</p> <p>Background</p> <p>Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one of the major effectors in this signaling network. Chronic AKT activation contributes to oncogenic transformation and tumor development. Therefore, analogs of phosphatidyl inositol phosphates (PIAs) were designed as new small drugs to block AKT activity for cancer treatment. Here we characterize the biological effects of the PIAs SH-5 and SH-6 in colorectal cancer cell lines.</p> <p>Methods</p> <p>Serum-starved or serum-supplemented human colorectal cancer cell lines SW480, HT29 and HCT116 were exposed to SH-5 and SH-6. AKT activation was determined by western blotting. Cell viability was assessed using a colorimetric XTT-based assay, apoptosis and cell cycle changes were monitored by FACS analysis. The dynamics of cell morphology alterations was evaluated by confocal and time-lapse microscopy. Transcriptional changes due to inhibitor treatment were analyzed using Affymetrix HG-U133A microarrays and RT-PCR.</p> <p>Results</p> <p>While the PIAs clearly reduce AKT phosphorylation in serum starved cells, we did not observe a significant reduction under serum supplemented conditions, giving us the opportunity to analyze AKT independent effects of these compounds. Both inhibitors induce broadly the same morphological alterations, in particular changes in cell shape and formation of intracellular vesicles. Moreover, we observed the induction of binucleated cells specifically in the SW480 cell line. Gene expression analysis revealed transcriptional alterations, which are mostly cell line specific. In accordance to the phenotype we found a gene group associated with mitosis and spindle organization down regulated in SW480 cells, but not in the other cell lines. A bioinformatics analysis using the Connectivity Map linked the gene expression pattern of the inhibitor treated SW480 cells to PKC signaling. Using confocal laser scanning microscopy and time lapse recording we identified a specific defect in the last step of the cytokinesis as responsible for the binucleation.</p> <p>Conclusions</p> <p>The PIAs SH-5 and SH-6 impinge on additional cellular targets apart from AKT in colorectal cancer cells. The effects are mostly cell line specific and have an influence at the outcome of the treatment. In view of potential clinical trials it will be necessary to take these diverse effects into consideration to optimize patient treatment.</p

The Third wave in globalization theory

This essay examines a proposition made in the literature that there are three waves in globalization theory—the globalist, skeptical, and postskeptical or transformational waves—and argues that this division requires a new look. The essay is a critique of the third of these waves and its relationship with the second wave. Contributors to the third wave not only defend the idea of globalization from criticism by the skeptics but also try to construct a more complex and qualified theory of globalization than provided by first-wave accounts. The argument made here is that third-wave authors come to conclusions that try to defend globalization yet include qualifications that in practice reaffirm skeptical claims. This feature of the literature has been overlooked in debates and the aim of this essay is to revisit the literature and identify as well as discuss this problem. Such a presentation has political implications. Third wavers propose globalist cosmopolitan democracy when the substance of their arguments does more in practice to bolster the skeptical view of politics based on inequality and conflict, nation-states and regional blocs, and alliances of common interest or ideology rather than cosmopolitan global structures

Mainstreaming Gender in the Context of Seaweed Farming SHGs in Ramanathapuram: A Pragmatic Evaluation

A pragmatic examination on the impact of women SHGs in gender mainstreaming was embarked on the 10 seaweed farming SHG units operating at Ramanathapuram district in Tamil Nadu state. An explorative assessment on extent of empowerment, performance level, gender characteristics and economic feasibility analysis was carried out based on socio-economic surveys and personal interviews using pre-tested and structured data gathering protocols with standardized scales and indices. Empowerment Index was quantified based on 8 relevant dimensions constituting it. The male and female counterparts of the families were separately interviewed to evaluate the gender mainstreaming aspects in terms of equity and equality to access to resources, participation profile, decision making aspects, gender need analysis etc. Though majority of activities are male dominated, the female counterparts of the households also have committed role in site selection, seeding, drying, packing etc. The Scales of ‘Performance Assessment’ and ‘Empowerment Index’ developed for this study have upright prospective for future use in other key areas on a sustainable basis. Voids identified in Empowerment Index computation give adequate feedback to authorities to proceed in the accurate direction and to follow apposite changes in strategies of the microenterprise. The gender dimension analysis on mainstreaming aspect gives sensitization on crucial issues like women fisherfolk’s rights and marketing channels for policies and other interventions on gender. The identified interrelationships between the variables an act as catalytic points for group action and empowerment on a maintainable basis. The indicative economics worked out for the economic feasibility analysis of the SHGs advocates that, the unit takes just one year to break even which shows the cost-effectiveness of the seaweed farming enterprise

Gender Mainstreaming and Impact of SHGs: A Pragmatic Expedition from the Fish Value Addition Sector of Kerala

A rational assessment of the impact of women SHGs in gender mainstreaming was conducted among the fish value addition production units operating at Puthuvypu and Arakkunnam of Ernakulam district in Kerala. Based on socioeconomic surveys and in-person interviews, analysis of empowerment levels, performance levels, gender characteristics, and economic viability were done using standardised data collection techniques. Empowerment Index was calculated using data based on 8 pertinent dimensions. To evaluate the gender mainstreaming features in terms of equity and equality to access to resources, participation profile, decision-making, etc., the male and female counterparts of the households were individually interviewed. Male equivalents play a compelling role in decision-making, the gathering of raw resources, the conveyance of the finished product, etc. even though women dominate most tasks. Lacunae identified in Empowerment Index computation give feedback to proceed in the right direction and to follow appropriate changes in the manoeuvre of the microenterprise. The indicative economics of the enterprise’s payback period of less than a year serve as evidence of its cost-effectiveness

Muslim Integration into Western Cultures: Between Origins and Destinations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91196/1/j.1467-9248.2012.00951.x.pd

The paradigm of gender mainstreaming and impact of SHGs in Indian fisheries sector: an ephemeral depiction

A study was made on the impact of 1000 selected ‘Self Help Groups’ (SHGs) in gender mainstreaming in marine fisheries sector. Their level of performance and extent of empowerment were assessed through appropriate indices of measurement based on data from SHGs of 30 different fishery based micro enterprises from 5 maritime states of India such as Kerala, Karnataka, Tamil Nadu, Andhra Pradesh and Odisha. The gender analysis and economic feasibility analysis based on personal interview and focus group interaction meetings with members of SHGs were undertaken. The male and female counterparts of the families of respondents were separately interviewed to assess the gender mainstreaming impact in terms of equity and equality to access and control over the resources, participation profile, decision making, gender need analysis etc. Analysis of data was essentially done with descriptive statistics such as mean, frequency, percentages, etc. As practical extension part, organized 250 fisherfolk interaction meetings and imparted 100 Entrepreneurial Capacity Building (ECB) Training programmes for the SHGs on the identified micro enterprises by HRD intervention programmes. The major micro enterprises of the SHGs studied were cage culture, bivalve farming, fish aggregating devices, Chinese dip net, clam processing, fish fertilizer, fish amino acid, fish drying, seaweed culture, aqua tourism, seafood kitchen, value addition, fish vending, fish marketing, ornamental fish, ready to eat and cook items, fish feed, aquaponics etc. Economic Feasibility analysis was done for the fishery based micro enterprises accomplished by SHGs and developed Business Plans of the microenterprises representing the indicative economics projecting the break even and payback period of micro-enterprises. Documented 100 success cases on ECB of SHGs with special reference to gender perspective. Brought out 25 video documentaries as Gender Mainstreaming series on Impact of SHGs in Marine Fisheries Sector as success case studies elucidated which can be used as case model for promoting group action and as a practical manual for mobilizing SHGs in any key areas on a sustainable basis

मात्स्यिकी में विज्ञान, प्रौद्योगिकी और नवाचार हबः एक क्षणिक चित्रण

मात्स्यिकी सेक्‍टर, कोच्चि कॉर्पोरेशन, एरणाकुलम जिला, के रल मेें विज्ञान, प्रौद्योगिकी और नवाचार हब’ भा कृ अनु प-केन्द्रीय समुद्री मात्स्यिकी अनुसंधान संस्थान (सी एम एफ आर आइ) को विज्ञान एवं प्रौद्योगिकी विभाग (डी एस टी), नई दिल्ली द्वारा वर्ष 2022-25 अवधि के लिए मंजूर की गयी 3.18 करोड़ रुपए की संस्थान बाहरी वित्‍त पोषित परियोजना है। परियोजना संस्थान की अवसंरचना के साथ-साथ अनुसूचित जाति के लाभार्थीयोथिं के लिए मात्स्यिकी पर आधारित हस्‍तक्षेप पर ध्यान देती है