Tricuspid annuloplasty concomitant with mitral valve surgery: Effects on right ventricular remodeling

ObjectivesTricuspid valve annuloplasty (TVP) has been advocated concomitantly with left-sided cardiac surgery in case of more than moderate tricuspid regurgitation (TR) or tricuspid annular dilation (TAD) (diameter >40 mm or 21 mm/m²) even in the absence of significant TR. Data on postoperative right ventricular (RV) remodeling are lacking in such patients.MethodsPreoperative and postoperative echocardiography data from 45 consecutive TVP procedures, performed in mitral valve surgery in a single tertiary center, were retrospectively analyzed and compared with a propensity-matched control group of 33 procedures without concomitant TVP. RV function and geometry was analyzed by measuring RV size, fractional area change, and end-diastolic sphericity index (RVSI = long-axis length/short-axis width) and compared at baseline versus follow-up.ResultsAt a mean follow-up of 5 months, a favorable change in RV geometry was observed in TVP patients (RVSI increased from 1.99 ± 0.33 to 2.21 ± 0.42; P = .001), whereas the opposite was observed in the control group (RVSI decreased from 2.34 ± 0.52 to 2.17 ± 0.13; P = .05). Only in control patients, indexed RV end-diastolic area increased significantly (P = .003). In TVP patients, when comparing patients with baseline more than moderate TR (n = 13) to patients with isolated TAD (n = 32), there was a significant decrease in RV end-diastolic area only in the group with more than moderate TR (from 12.9 ± 3.5 cm2/m2 to 10.3 ± 1.9 cm2/m2; P = .009).ConclusionsAdding TVP to mitral valve surgery in patients with more than moderate TR or TAD leads to favorable changes in RV geometry and prevents postoperative RV dilation. This is most pronounced in patients with more than moderate TR at baseline

Global observations of fine-scale ocean surface topography with the surface water and ocean topography (SWOT) mission

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in [citation], doi:[doi]. Morrow, R., Fu, L., Ardhuin, F., Benkiran, M., Chapron, B., Cosme, E., d'Ovidio, F., Farrar, J. T., Gille, S. T., Lapeyre, G., Le Traon, P., Pascual, A., Ponte, A., Qiu, B., Rascle, N., Ubelmann, C., Wang, J., & Zaron, E. D. Global observations of fine-scale ocean surface topography with the surface water and ocean topography (SWOT) mission. Frontiers in Marine Science, 6(232),(2019), doi:10.3389/fmars.2019.00232.The future international Surface Water and Ocean Topography (SWOT) Mission, planned for launch in 2021, will make high-resolution 2D observations of sea-surface height using SAR radar interferometric techniques. SWOT will map the global and coastal oceans up to 77.6∘ latitude every 21 days over a swath of 120 km (20 km nadir gap). Today’s 2D mapped altimeter data can resolve ocean scales of 150 km wavelength whereas the SWOT measurement will extend our 2D observations down to 15–30 km, depending on sea state. SWOT will offer new opportunities to observe the oceanic dynamic processes at scales that are important in the generation and dissipation of kinetic energy in the ocean, and that facilitate the exchange of energy between the ocean interior and the upper layer. The active vertical exchanges linked to these scales have impacts on the local and global budgets of heat and carbon, and on nutrients for biogeochemical cycles. This review paper highlights the issues being addressed by the SWOT science community to understand SWOT’s very precise sea surface height (SSH)/surface pressure observations, and it explores how SWOT data will be combined with other satellite and in situ data and models to better understand the upper ocean 4D circulation (x, y, z, t) over the next decade. SWOT will provide unprecedented 2D ocean SSH observations down to 15–30 km in wavelength, which encompasses the scales of “balanced” geostrophic eddy motions, high-frequency internal tides and internal waves. This presents both a challenge in reconstructing the 4D upper ocean circulation, or in the assimilation of SSH in models, but also an opportunity to have global observations of the 2D structure of these phenomena, and to learn more about their interactions. At these small scales, ocean dynamics evolve rapidly, and combining SWOT 2D SSH data with other satellite or in situ data with different space-time coverage is also a challenge. SWOT’s new technology will be a forerunner for the future altimetric observing system, and so advancing on these issues today will pave the way for our future.The authors were mostly funded through the NASA Physical Oceanography Program and the CNES/TOSCA programs for the SWOT and OSTST Science teams. AnP acknowledges support from the Spanish Research Agency and the European Regional Development Fund (Award No. CTM2016-78607-P). AuP acknowledges support from the ANR EQUINOx (ANR-17-CE01-0006-01)

Lumbar spinal muscles and spinal canal study by MRI three-dimensional reconstruction in adult lumbar spinal stenosis

Background: Lumbar spinal stenosis is degenerative disc disease most common manifestation. If stenosisdegree seems poorly related to symptom severity, lumbar muscles role is recognized. Many studiesreport imaging methods, to analyze muscle volumes and fat infiltration (FI), but remain limited due tothe difficulty to represent entire muscle volume variability. Recently a 3D muscle reconstruction protocol(using the deformation of a parametric specific object method (DPSO) and three-point Dixon images) wasreported. It offers the ability to evaluate, muscles volumes and muscle FI.Purpose: To describe, in a lumbar spinal stenosis population, muscle volumes, muscle FI and lumbarspinal canal volume with 3D MRI images reconstructions.Materials and methods: Ten adults presenting L4–L5 lumbar stenosis, were included. After specific MRIprotocol, three-dimensional, muscle and spinal canal, reconstructions were performed. Muscle (psoasand paraspinal muscles) volumes and fat infiltration (FI), the spinal canal volume, age, and height werecorrelated one to each other with Spearman correlation factor. An ANOVA was performed to evaluate theintervertebral level influence (P ≤ 0.05).Results: Muscle volumes correlated with height (r = 0.68 for psoas). Muscles FI correlated with age (r = 0.66for psoas) and lumbar spinal canal volume (r = 0.91). Psoas and paraspinal volumes were maximum atL3–L4 level whereas FI increased from L1–L2 to L5–S1 level.Discussion: These first results illustrate the importance to consider muscles entirely and report correla-tions between muscles FI, lumbar spinal canal volume and age; and between muscle volumes and patientsheight. Muscle degeneration seems more related to muscle FI than muscle volume.Level of evidence: 3.The authors declare that they have no competing interest

Global Observations of Fine-Scale Ocean Surface Topography With the Surface Water and Ocean Topography (SWOT) Mission

The future international Surface Water and Ocean Topography (SWOT) Mission, planned for launch in 2021, will make high-resolution 2D observations of sea-surface height using SAR radar interferometric techniques. SWOT will map the global and coastal oceans up to 77.6 latitude every 21 days over a swath of 120 km (20 km nadir gap). Today’s 2D mapped altimeter data can resolve ocean scales of 150 km wavelength whereas the SWOT measurement will extend our 2D observations down to 15–30 km, depending on sea state. SWOT will offer new opportunities to observe the oceanic dynamic processes at scales that are important in the generation and dissipation of kinetic energy in the ocean, and that facilitate the exchange of energy between the ocean interior and the upper layer. The active vertical exchanges linked to these scales have impacts on the local and global budgets of heat and carbon, and on nutrients for biogeochemical cycles. This review paper highlights the issues being addressed by the SWOT science community to understand SWOT’s very precise sea surface height (SSH)/surface pressure observations, and it explores how SWOT data will be combined with other satellite and in situ data and models to better understand the upper ocean 4D circulation (x, y, z, t) over the next decade. SWOT will provide unprecedented 2D ocean SSH observations down to 15–30 km in wavelength, which encompasses the scales of “balanced” geostrophic eddy motions, high-frequency internal tides and internal waves. Frontiers in Marine Science | www.frontiersin.org 1 May 2019 | Volume 6 | Article 232 Morrow et al. SWOT Fine-Scale Global Ocean Topography This presents both a challenge in reconstructing the 4D upper ocean circulation, or in the assimilation of SSH in models, but also an opportunity to have global observations of the 2D structure of these phenomena, and to learn more about their interactions. At these small scales, ocean dynamics evolve rapidly, and combining SWOT 2D SSH data with other satellite or in situ data with different space-time coverage is also a challenge. SWOT’s new technology will be a forerunner for the future altimetric observing system, and so advancing on these issues today will pave the way for our future

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against Mycobacterium tuberculosis. To ensure compound supply for further development, we studied myxovalargin biosynthesis in detail enabling production via fermentation of a native producer. Feeding experiments as well as functional genomics analysis suggested a structural revision, which was eventually corroborated by the development of a concise total synthesis. The ribosome was identified as the molecular target based on resistant mutant sequencing, and a cryo-EM structure revealed that myxovalargin binds within and completely occludes the exit tunnel, consistent with a mode of action to arrest translation during a late stage of translation initiation. These studies open avenues for structure-based scaffold improvement toward development as an antibacterial agent

Using habitat models for chinstrap penguins Pygoscelis antarctica to advise krill fisheries management during the penguin breeding season

Aim: To predict the at‐sea distribution of chinstrap penguins across the South Orkney Islands and to quantify the overlap with the Southern Ocean krill fishery. Location: South Orkney Islands, Antarctica. Methods: Penguins from four colonies across the South Orkney Islands were tracked using global positioning systems (GPSs) and time depth recorders (TDRs). Relationships between a variety of environmental and geometric variables and the at‐sea distribution of penguins were investigated using general additive models for the three main phases of the breeding season. Subsequently, the final models were extrapolated across the South Orkney archipelago to predict the at‐sea distribution of penguins from colonies where no tracking data are available. Finally, the overlap between areas used by chinstrap penguins and the krill fishery was quantified. Results: The foraging distribution of chinstrap penguins can be predicted using two simple and static variables: the distance from the colony and the direction of travel towards the shelf‐edge, while avoiding high densities of Pygoscelis penguins from other colonies. Additionally, we find that the chinstrap penguins breeding on the South Orkney Islands use areas which overlap with frequently used krill fishing areas and that this overlap is most prominent during the brood and crèche phases of the breeding season. Main conclusions: This is the first step in understanding the potential impacts of the krill fishery, for all colonies including those where no empirical tracking data are available. However, with the available data, it is not currently possible to infer an impact of the krill fisheries on penguins. With this in mind, we recommend the implementation of monitoring schemes to investigate the effects of prey depletion on predator populations and to ensure that management continues to follow a precautionary approach and is addressed at spatial and temporal scales relevant to ecosystem operation

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Abstract: Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers

Les inventeurs célèbres

Gille Bertrand. Les inventeurs célèbres. In: Revue d'histoire des sciences et de leurs applications, tome 4, n°2, 1951. pp. 197-198