28,037 research outputs found
Comment on "Exclusion of time in the theorem of Bell" by K. Hess and W. Philipp
A recent Letter by Hess and Philipp claims that Bell's theorem neglects the
possibility of time-like dependence in local hidden variables, hence is not
conclusive. Moreover the authors claim that they have constructed, in an
earlier paper, a local realistic model of the EPR correlations. However, they
themselves have neglected the experimenter's freedom to choose settings, while
on the other hand, Bell's theorem can be formulated to cope with time-like
dependence. This in itself proves that their toy model cannot satisfy local
realism, but we also indicate where their proof of its local realistic nature
fails.Comment: Latex needs epl.cl
A new code for parameter estimation in searches for gravitational waves from known pulsars
We describe the consistency testing of a new code for gravitational wave
signal parameter estimation in known pulsar searches. The code uses an
implementation of nested sampling to explore the likelihood volume. Using fake
signals and simulated noise we compare this to a previous code that calculated
the signal parameter posterior distributions on both a grid and using a crude
Markov chain Monte Carlo (MCMC) method. We define a new parameterisation of two
orientation angles of neutron stars used in the signal model (the initial phase
and polarisation angle), which breaks a degeneracy between them and allows more
efficient exploration of those parameters. Finally, we briefly describe
potential areas for further study and the uses of this code in the future.Comment: Accepted for proceedings of Amaldi 9 meetin
Signatures of Strong Momentum Localization via Translational-Internal Entanglement
We show that atoms or molecules subject to fields that couple their internal
and translational (momentum) states may undergo a crossover from randomization
(diffusion) to strong localization (sharpening) of their momentum distribution.
The predicted crossover should be manifest by a drastic change of the
interference pattern as a function of the coupling fields.Comment: 4 pages, 3 figure
Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling
The relative roles of SULF1 and SULF2 enzymes in tumour growth are controversial, but short SULF1/SULF2 splice variants predominate in human mammary tumours despite their non-detectable levels in normal mammary tissue. Compared with the normal, the level of receptor tyrosine kinase (RTK) activity was markedly increased in triple-positive mammary tumours during later stages of tumour progression showing increased p-EGFR, p-FGFR1 and p-cMet activity in triple-positive but not in triple-negative tumours. The abundance of catalytically inactive short SULF1/SULF2 variants permits high levels of HS sulphation and thus growth driving RTK cell signalling in primary mammary tumours. Also observed in this study, however, was increased N-sulphation detected by antibody 10E4 indicating that not only 6-O sulphation but also N-sulphation may contribute to increased RTK cell signalling in mammary tumours. The levels of such increases in not only SULF1/SULF2 but also in pEGFR, pFGFR1, p-cMet and Smad1/5/8 signalling were further enhanced following lymph node metastasis. The over-expression of Sulf1 and Sulf2 variants in mammary tumour-derived MDA-MB231 and MCF7 cell lines by transfection further confirms Sulf1-/Sulf2-mediated differential modulation of growth. The short variants of both Sulf1 and Sulf2 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth. Since a number of mammary tumours become drug resistant to hormonal therapy, Sulf1/Sulf2 inhibition could be an alternative therapeutic approach to target such tumours by down-regulating RTK-mediated cell signalling
Two electrons on a hypersphere: a quasi-exactly solvable model
We show that the exact wave function for two electrons, interacting through a
Coulomb potential but constrained to remain on the surface of a
-sphere (), is a polynomial in the
interelectronic distance for a countably infinite set of values of the
radius . A selection of these radii, and the associated energies, are
reported for ground and excited states on the singlet and triplet manifolds. We
conclude that the model bears the greatest similarity to normal
physical systems.Comment: 4 pages, 0 figur
Deterministic entanglement of two neutral atoms via Rydberg blockade
We demonstrate the first deterministic entanglement of two individually
addressed neutral atoms using a Rydberg blockade mediated controlled-NOT gate.
Parity oscillation measurements reveal an entanglement fidelity of
, which is above the entanglement threshold of , without
any correction for atom loss, and after correcting for
background collisional losses. The fidelity results are shown to be in good
agreement with a detailed error model.Comment: 4 figure
Triple cascade behaviour in QG and drift turbulence and generation of zonal jets
We study quasigeostrophic (QG) and plasma drift turbulence within the Charney-Hasegawa-Mima (CHM) model. We focus on the zonostrophy, an extra invariant in the CHM model, and on its role in the formation of zonal jets. We use a generalized Fjørtoft argument for the energy, enstrophy, and zonostrophy and show that they cascade anisotropically into nonintersecting sectors in k space with the energy cascading towards large zonal scales. Using direct numerical simulations of the CHM equation, we show that zonostrophy is well conserved, and the three invariants cascade as predicted by the Fjørtoft argument
Why is timing of bird migration advancing when individuals are not?
Recent advances in spring arrival dates have been reported in many migratory species but the mechanism driving these advances is unknown. As population declines are most widely reported in species that are not advancing migration, there is an urgent need to identify the mechanisms facilitating and constraining these advances. Individual plasticity in timing of migration in response to changing climatic conditions is commonly proposed to drive these advances but plasticity in individual migratory timings is rarely observed. For a shorebird population that has significantly advanced migration in recent decades, we show that individual arrival dates are highly consistent between years, but that the arrival dates of new recruits to the population are significantly earlier now than in previous years. Several mechanisms could drive advances in recruit arrival, none of which require individual plasticity or rapid evolution of migration timings. In particular, advances in nest-laying dates could result in advanced recruit arrival, if benefits of early hatching facilitate early subsequent spring migration. This mechanism could also explain why arrival dates of short-distance migrants, which generally return to breeding sites earlier and have greater scope for advance laying, are advancing more rapidly than long-distance migrants
Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily
AbstractMicronemes are specialised organelles, found in all apicomplexan parasites, which secrete molecules that are essential for parasite attachment to and invasion of host cells. Regions of several microneme proteins have sequence similarity to the Apple domains (A-domains) of blood coagulation factor XI (FXI) and plasma pre-kallikrein (PK). We have used mass spectrometry on a recombinant-expressed, putative A-domain from the microneme protein EtMIC5 from Eimeria tenella, to demonstrate that three intramolecular disulphide bridges are formed. These bridges are analogous to those that stabilise A-domains in FXI and PK. The data confirm that the apicomplexan domains are structural homologues of A-domains and are therefore novel members of the PAN module superfamily, which also includes the N-terminal domains of members of the plasminogen/hepatocyte growth factor family. The role of A-domains/PAN modules in apicomplexan parasites is not known, but their presence in the microneme suggests that they may be important for mediating proteinâprotein or proteinâcarbohydrate interactions during parasite attachment and host cell invasion
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