Treatment planning for the lung cancer

This article is a letter to editor, and it doesn't include an abstract. Full text of this article is available in HTML and PDF.Cite this article as: Gill S. Treatment planning for lung cancer. Int J Cancer Ther Oncol 2014; 2(1):020117.DOI: http://dx.doi.org/10.14319/ijcto.0201.17

The monopole and quadrupole moments of the Epoch of Reionization (EoR) 21-cm bispectrum

We study the monopole ($\bar{B}^0_0$) and quadrupole ($\bar{B}^0_2$) moments of the 21-cm bispectrum (BS) from EoR simulations and present results for squeezed and stretched triangles. Both $\bar{B}^0_0$ and $\bar{B}^0_2$ are positive at the early stage of EoR where the mean neutral hydrogen (HI) density fraction $\bar{x}_{\rm HI} \approx 0.99$. The subsequent evolution of $\bar{B}^0_0$ and $\bar{B}^0_2$ at large and intermediate scales $(k=0.29$ and $0.56 \, {\rm Mpc}^{-1}$ respectively) is punctuated by two sign changes which mark transitions in the HI distribution. The first sign flip where $\bar{B}^0_0$ becomes negative occurs in the intermediate stages of EoR $(\bar{x}_{\rm HI} > 0.5)$, at large scale first followed by the intermediate scale. This marks the emergence of distinct ionized bubbles in the neutral background. $\bar{B}^0_2$ is relatively less affected by this transition, and it mostly remains positive even when $\bar{B}^0_0$ becomes negative. The second sign flip, which affects both $\bar{B}^0_0$ and $\bar{B}^0_2$, occurs at the late stage of EoR $(\bar{x}_{\rm HI} < 0.5)$. This marks a transition in the topology of the HI distribution, after which we have distinct HI islands in an ionized background. This causes $\bar{B}^0_0$ to become positive. The negative $\bar{B}^0_2$ is a definite indication that the HI islands survive only in under-dense regions.Comment: Accepted for publication in MNRA

Treatment planning for the lung cancer

This article is a letter to editor, and it doesn't include an abstract. Full text of this article is available in HTML and PDF.Cite this article as: Gill S. Treatment planning for lung cancer. Int J Cancer Ther Oncol 2014; 2(1):020117.DOI: http://dx.doi.org/10.14319/ijcto.0201.17 </p

Reactor Design for Partial Upgrading of Bitumen via Aquaprocessing

Alberta oil industry is facing a major challenge because of the widening price differentials between West Texas Intermediate and Western Canadian Select. The Western Canadian Select is trading at low of US$ 16.71 /bbl. because of its high viscosity, density, total acid number, and sulfur content and lack of access to market outside North America. Under these circumstances, partial upgrading processes such as Aquaprocessing are envisioned as a potential solution. The synthetic crude oil produced from Aquaprocessing of bitumen requires 50 vol.% less diluents than the Athabasca bitumen to meet the pipeline specifications. This thesis is focused on evaluating the reactor design parameters required for scale-up of this technology. The kinetic parameters for hydrocracking reaction were calculated using first-order rate law expression for the packed bed reactor. Diffusivity of steam in bitumen, dimensionless numbers and hydrodynamic properties of the fluid inside the reactor were calculated using experimental and simulated data. The experimental results indicate that the effect of catalyst particle size depends on the catalyst preparation techniques. The steam diffusivity in bitumen was found to increase linearly with increase in reaction temperature. 0.05 psi/m pressure drop and 39 vol.% liquid holdups are predicted for the two-phase flow regime

Isolation of 4-aminopyridine resistant mutants affecting alkali-insoluble glucan content of cell walls in <i>Saccharomyces cerevisiae</i>

897-901Saccharomyces cerevisiae cells when grown on synthetic medium plates containing 10 mM of 4-aminopyridine (4-AP) undergo cell lysis. Using an ethylmethane sulfonate mutagenesis (EMS) screen, 4-AP resistant mutants (apr) were isolated which could grow on inhibitory concentration of 4-AP. Eighty mutants were obtained that were recessive, monogenic and formed two complementation groups. To identify genes, whose products might be interacting with the apr loci, extragenic suppressors were isolated, which reverted 4-AP resistance phenotype of apr mutants. The suppressors, when genetically characterized, were found to be recessive and represented two loci with overlapping functions. Representative alleles from apr <span style="font-size:12.0pt; line-height:115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:hi"="">mutants were analyzed for cell wall composition. They were found to have a higher amount of alkali-insoluble glucan signifying the role of alkali-insoluble glucan in cell wall maintenance.</span

Wound problems following hip arthroplasty before and after the introduction of a direct thrombin inhibitor for thromboprophylaxis

NICE guidelines have stated that patients undergoing elective hip surgery are at increased risk for venous thromboembolic events (VTE) following surgery and have recommended thromboprophylaxis for 28-35 days1, 2. However the studies looking at the new direct thrombin inhibitors have only looked at major bleeding. We prospectively looked at wound discharge in patients who underwent hip arthroplasty and were given dabigatran postoperatively between March 2010 and April 2010 (n=56). We retrospectively compared these results to a matched group of patients who underwent similar operations six months earlier when all patients were given dalteparin routinely postoperatively until discharge, and discharged home on 150mg aspirin daily for 6 weeks (n=67). Wound discharge after 5 days was significantly higher in the patients taking dabigatran (32% dabigatran n=18, 10% dalteparin n=17, p=0.003) and our rate of delayed discharges due to wound discharge significantly increased from 7% in the dalteparin group (n=5) to 27% for dabigatran (n=15, p=0.004). Patients who received dabigatran were more than five times as likely to return to theatre with a wound complication as those who received dalteparin (7% dabigatran n=4, vs. 1% dalteparin n=1), however, this was not statistically significant (p=0.18). The significantly higher wound discharge and return to theatre rates demonstrated in this study have meant that we have changed our practice to administering dalteparin until the wound is dry and then starting dabigatran. Our study demonstrates the need for further clinical studies regarding wound discharge and dabigatran

Chemically Stable Proton Conducting Doped BaCeO3 -No More Fear to SOFC Wastes

Development of chemically stable proton conductors for solid oxide fuel cells (SOFCs) will solve several issues, including cost associated with expensive inter-connectors and long-term durability. Best known Y-doped BaCeO3 (YBC) proton conductors-based SOFCs suffer from chemical stability under SOFC by-products including CO2 and H2O. Here, for the first time, we report novel perovskite-type Ba0.5Sr0.5Ce0.6Zr0.2Gd0.1Y0.1O3?? by substituting Sr for Ba and co-substituting Gd + Zr for Ce in YBC that showed excellent chemical stability under SOFC by-products (e.g., CO2 and H2O) and retained a high proton conductivity, key properties which were lacking since the discovery of YBCs. In situ and ex- situ powder X-ray diffraction and thermo-gravimetric analysis demonstrate superior structural stability of investigated perovskite under SOFC by-products. The electrical measurements reveal pure proton conductivity, as confirmed by an open circuit potential of 1.15?V for H2-air cell at 700°C and merits as electrolyte for H-SOFCs