How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis?

Abstract Background Lymphatic vessels are major routes for metastasis in head and neck squamous cell carcinoma (HNSCC), but lymphatic endothelial cells (LECs) are difficult to recognize in tumor histological sections. D2-40 stains podoplanin, a molecule expressed in LECs, however, the potential prognostic usefulness of this molecule is not completely understood in HNSCC. We aimed to investigate the value of assessing peritumoral and intratumoral lymphatic vessel density (LVD) as prognostic marker for HNSCC. Methods Thirty-one cases of HNSCC were stained for D2-40 and CD31. LVD and blood vessel density (BVD) were assessed by counting positive reactions in 10 hotspot areas at ×200 magnification. Results D2-40 was specific for lymphatic vessels and did not stain blood vascular endothelial cells. LECs showed more tortuous and disorganized structure in intratumoral lymphatic vessels than in peritumoral ones. No statistical differences were observed between peritumoral-LVD and intratumoral-LVD or between peritumoral-BVD and intratumoral-BVD. Tumor D2-40 staining was positively associated with lymphatic vessel invasion (p = 0.011). Conclusion LVD is a powerful marker for HNSCC prognosis. We found significant differences in peritumoral and intratumoral D2-40 immunoreactivity, which could have important implications in future therapeutic strategies and outcome evaluation

Antisymmetric Magnetic Interactions in Oxo-Bridged Copper(II) Bimetallic Systems

The antisymmetric magnetic interaction is studied using correlated wave-function-based calculations in oxo-bridged copper bimetallic complexes. All of the anisotropic multispin Hamiltonian parameters are extracted using spin-orbit state interaction and effective Hamiltonian theory. It is shown that the methodology is accurate enough to calculate the antisymmetric terms, while the small symmetric anisotropic interactions require more sophisticated calculations. The origin of the antisymmetric anisotropy is analyzed, and the effect of geometrical deformations is addressed.

Modelling Mineral Foam Morphology Dynamics for Stability and Insulation Properties

Mineralized foam is an upcoming cementitious material that can be used as a sustainable building material. In view of recycling potential mineral foam has a cementitious microstructure that makes it a “clean” recyclable material. Designing mineral foam is a technology that demands control of the foam structure and the foam stability. From its basic state, mineral foam has an instable morphology that is continuously changing as long as the foam bubbles didn’t got frozen by setting/hardening of cementitious paste. This principle is making the material sensitive for its bubble and pore structure. In this paper, a schematic model is presented with which the bubble morphology and its associated foam stability can be simulated. The foam morphology dynamics was described by merging of different model foam structures having different characteristic bubble sizes, mixed in various volumetric ratios. A linear relationship was found between the degree of merging of different foam structures and the maximum bubble diameter in the foam system. The model turned out to have a great potential in making mineral foam predictable and designable

Electronic spectrum of the propargyl cation (H2C3H+) tagged with Ne and N-2

The Ã(1)A1 ← X̃(1)A1 band system of the propargyl cation (H2C3H(+)) is measured over the 230-270 nm range by photodissociation of mass-selected H2C3H(+)-Ne and H2C3H(+)-N2 complexes in a tandem mass spectrometer. The band origin occurs at 37 618 cm(-1) for H2C3H(+)-Ne and 37 703 cm(-1) for H2C3H(+)-N2. Ground and excited state ab initio calculations for H2C3H(+) using the MCSCF and coupled-cluster (CC) response methods show that the ion has C2v symmetry in the ground X̃(1)A1 and excited Ã(1)A1 states and that the strong vibronic progression with a spacing of 630 cm(-1) is due to the C-C stretch vibrational mode, ν 5

Hydrating Cement Particle Interaction Model for Yield Stress Analysis

This study overviews existing methods for analyzing cement paste yield stress, and presents a new approach based on micro-structural computation. The proposed model explicitly considers cement particle interactions, both the colloidal and the nucleated gel ones. A new algorithm is proposed based on flocculating of poly-dispersed hard spheres in a simulation box, followed by nucleation of mono-sized nano-gel particles. The obtained virtual microstructures are than used as an input for a mechanical approach, which is conceptualized for simulating sliding kinematics needed to initiate the flow of the percolated solid network, i.e. to reach the paste yield stress. The microstructural modeling tool provides insights on how the localized gel is bridging the cement particles, responsible for the yield stress properties of bulk cement paste. Thus, it provides a promising new approach for quantifying the evolution of the bridging strength with nucleation (shear rest) time, enabling parametrization of the mechanical yield stress computation at micro-structural scale