Bone remodeling markers after experimental augmentation of trabecular bone defects with resorbable and non-resorbable osteoplastic materials in rabbits

To study the effect of bone defect augmentation on the dynamics of bone remodeling markers. Material and methods The effect of resorbable xenoplastic material (RXM), synthetic beta-tricalcium phosphate (b-TCP), porous titanium implant (PTI) and nanostructured carbon implant (NCI) on the markers of bone remodeling (osteocalcin, OC; bone alkaline phosphatase, BALP; C-terminal telopeptide of type I collagen, CTX-1) and inflammation marker (C-reactive protein, CRP) was investigated using bone defect model in rabbits. 24 animals were divided into 4 groups (n = 6 in each group) according to the type of osteoplastic material. Control group (n = 6) was without augmentation. An impression fracture of the proximal tibia was modeled. Blood samples were taken on days 1, 3, 7, 14, 45, 90, 180 after surgery. Results CTX-1was not detected in the control, b-TCP, PTI, and RXM groups after 90 days, but in the NCI group CTX-1 remained elevated until the end of the study. OC in the control, b-TCP, PTI groups reached a maximum at 14-45 days. No significant increase in OC was found in the NCI group. The BALP in the control group peaked at 90 days. In the b-TCP and PTI groups the concentration of BALP increased more rapidly. The dynamics of CRP in the RXM, b-TCP and PTI groups was similar to the dynamics in the control group, in the NCI group an increased level of CRP remained until the end of the study. Conclusion When a bone defect was augmented with both resorbable b-TCP and nonresorbable PTI, high osteogenesis activity and low osteoresorption activity were detected. The use of xenoplastic material did not reveal any advantages in comparison with surgery performed without augmentation. An increase in osteoresorption and a low level of osteogenesis were found by using NCI. © Yildiz K., Yildiz V., 2020

Imitation model of the electric trolley overhead crane

The article focuses on the analysis of the interaction between electric trolley and the cargo of the overhead crane. The influence of static and dynamic forces on the movement of the trolley and the cargo is examined, the reasons for the free fluctuations of the cargo are investigated. A computer model for studying the interaction of the cargo and the electric drive of the trolley is presented.В статье основное внимание уделяется анализу взаимодействия электропривода тележки и груза мостового крана. Рассматривается влияние статических и динамических сил на движение тележки и груза, исследуются причины свободных колебаний груза. Представлена компьютерная модель для изучения взаимодействия груза и электропривода тележки

Innovative tools of improoving the quality of postgraduate education in orthopaedic

The article shows the experience of the Department of traumatology and orthopedics for professional doctors training. Innovative approaches in teaching are in the multimedia presentation of the course material, combining lectures with practical master classes, independent performing surgeries on artificial bones and biomodels.В статье приведен опыт работы кафедры травматологии и ортопедии ФПК и ПП по профессиональной подготовке врачей травматологов-ортопедов. Инновационные подходы, используемые при обучении, заключаются в мультимедийном представлении учебного материала, совмещении лекций с практическими мастер-классами, самостоятельным выполнением хирургических вмешательств на искусственных костях и биоманекенах

Al-Cu-Zr MODIFYING ADDITIONS FOR ALUMINUM ALLOYS

The effect of small additions of zirconium and copper on the grain refinement of the Ak7 alloy and its structural components is considered. Additives were introduced both in the form of an experimental Al-Cu-Zr complex ligature and Al-Cu and Al-Zr binary alloys

Development of high-entropy eutectic alloys for structural applications

The systems AlCoFeNiTi, CoCuFeNiTi, AlCoCrFeNi are considered from the point of view of creating structural alloys with a eutectic structure

Modification of Silumins with Complex Additives of Cu with Zr AND Cu with Ti

The modifying ability of the experimental Al-Cu-Ti, Al-Cu-Zr master alloys on the industrial alloy Al-7%Si-0.45Mg (A396, Ak7h) was evaluated and compared with the commercial Al-Ti-B master alloy. Modification was carried out in a bucket with a melt mass of 60 kg

Computer simulation’s methods in the trauma profile operation planning

This article discusses the method of planning the operation of the trauma profile using modern 3D-modeling program.В данной статье приводится способ планирования операции травматологического профиля при помощи современной программы 3D-моделирования

DOPED LANTHANUM NICKELATES AS A CATHODE FOR SOLID OXIDE FUEL CELLS

La1.4A0.6Ni0.6Fe0.4O4+δ (A=Ca, Sr, Ba; LANF0604) were synthesized via citrate-nitrate method. Total conductivity (σ) of LANF0604 shows little variation versus the radius of dopant (≈30 S/cm at 800 °C). The lowest polarization resistance of 0.42 Ω cm2 was obtained for A=Ba at 800 °C.Работа выполнена при финансовой поддержке Министерства науки и высшего образования РФ (FEUZ-2023-0016)

Association of family history of stroke with increased prevalence of arterial hypertension in patients with ischemic stroke and TIA

The purpose of this study was to analyze the influence of family history of stroke on prevalence of other risk factors of stroke in patients with ischemic stroke and transient ischemic attacks (TIA). Material and methods: The study included 371 patients with ischemic stroke (83.6%) or TIA (16.4%) (225 males, 146 females, mean age 54.6). This group was subdivided on two subgroups: 149 (40.2%) patients with family history of stroke and 222 (59.8%) patients without family history of stroke. As a control we used 150 blood donors (75 males, 75 females, mean age 50.1) without stroke or TIA. In both groups we analyzed the following risk factors: smoking, consumption of light and strong alcoholic beverages, hypertension, increased body mass index >25, low physical activity, hypercholesterolemia, diabetes mellitus, hyperglycemia, atrial fibrillation. Information about these risk factors was obtained by neurologist during interview of patients and from available investigations in medical documentation. Results: The prevalence of family history of stroke was 40.1 %. We found significant difference In prevalence of arterial hypertension in patients with stroke/ПА who had family history of stroke compare to patients with stroke/TIA without family history of stroke (p=0.04, OR 2.1; 95% Cl 1.0-4.5). This association between family history of stroke and hypertension suggests that familial susceptibility to cerebral ischemia is attributable, at least partly, to familial predisposition to hypertension. Conclusion: Patients with stroke/ПА and family history of stroke have increased prevalence of arterial hypertension. This should be taken into account in stroke prevention.Целью данного исследования был анализ влияния семейного анамнеза инсульта на встречаемость других факторов риска развития острого наррения мозгового кровообращения (ОНМК) у больных с ишемическим инсультом и транзиторной ишемической атакой (ТИА). Материалы и методы: Данное исследование включало 371 больного с ОНМК (225 мужчин, 146 женщин, средний возраст 54.6 лет). Из них 310 (83.5%) больных перенесли ишемический инсульт и 61 (16.5%) пациент - ТИА. Все больные с ОНМК были разделены на 2 подгруппы: 149 (40.2%) пациентов с семейным анамнезом инсультов и 222 (59.8%) без семейного анамнеза инсультов. Контрольную группу составили 150 доноров крови без ОНМК (75 мужчин, 75 женщин, средний возраст 50.1). В этих группах оценивались такие факторы риска ОНМК как курение, употребление слабоалкогольных и крепких алкогольных налитков, артериальная гипертензия, повышенный индекс массы тела, гиподинамия, гиперхолестеринемия, сахарный диабет, гипертикемия и мерцательная аритмия. Информация об этих факторах риска была получена неврологом в процессе интервью больных, атакже при анализе их обследований в историях болезни. Результаты: Распространенность семейного анамнеза инсультов в группе больных с ОНМК составила 40,1%. При сравнении встречаемости факторов риска среди пациентов с семейным анамнезом инсульта и при его отсутствии выявлено, что только наличие артериальной гипертензии имеет знаимые различия в группе больных с ОНМК и семейным анамнезом инсультов (р=0.04, OR 2.1; 95% Cl 1.0-4.5). Эта ассоциация может свидетельствовать о том, что семейная предрасположенность к инсульту связана, по крайней мере частично, с семейной предрасположенностью к артериальной гипертензии. Вывод: Больные с ОНМК и семейным анамнезом инсульта имеют повышенную встречаемость артериальной гипертензии, что необходимо учитывать в профилактике инсульта