7,967 research outputs found
Associations between congenital malformations and childhood cancer. A register-based case-control study.
This report describes a population-based case-control study that aimed to assess and quantify the risk of children with congenital malformations developing cancer. Three sources of data were used: the Victorian Cancer Register, the Victorian Perinatal Data Register (VPDR) and the Victorian Congenital Malformations/Birth Defects Register. Cases included all Victorian children born between 1984 and 1993 who developed cancer. Four controls per case, matched on birth date, were randomly selected from the VPDR. Record linkage between registers provided malformation data. A matched case-control analysis was undertaken. Of the 632 cancer cases, 570 (90.2%) were linked to the VPDR. The congenital malformation prevalence in children with cancer was 9.6% compared with 2.5% in the controls [odds ratio (OR) 4.5, 95% CI 3.1-6.7]. A strong association was found with chromosomal defects (OR=16.7, 95% CI 6.1-45.3), in particular Down's syndrome (OR=27.1, 95% CI 6.0-122). Most other birth defect groups were also associated with increased cancer risk. The increased risk of leukaemia in children with Down's syndrome was confirmed, and children with central nervous system (CNS) defects were found to be at increased risk of CNS tumours. The report confirms that children with congenital malformations have increased risks of various malignancies. These findings may provide clues to the underlying aetiology of childhood cancer, as congenital malformations are felt to be a marker of exposures or processes which may increase cancer risk. The usefulness of record linkage between accurate population-based registers in the epidemiological study of disease has also been reinforced
Universality and Clustering in 1+1 Dimensional Superstring-Bit Models
We construct a 1+1 dimensional superstring-bit model for D=3 Type IIB
superstring. This low dimension model escapes the problems encountered in
higher dimension models: (1) It possesses full Galilean supersymmetry; (2) For
noninteracting polymers of bits, the exactly soluble linear superpotential
describing bit interactions is in a large universality class of superpotentials
which includes ones bounded at spatial infinity; (3) The latter are used to
construct a superstring-bit model with the clustering properties needed to
define an -matrix for closed polymers of superstring-bits.Comment: 11 pages, Latex documen
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Electroforming cell design tool development
The Electroforming Advisor (EFA) team has developed a prototype of an EFA, an easy-to-use design and computational problem solving environment for Electroforming. A primary goal is to enable electroformers to optimally design a cell that would make a part right the first time and with minimum cost. Computer simulations can be carried out much faster than experimentation and without hazardous waste production. The EFA prototype uses the Computer-Aided Design (CAD) and the Computer-Aided Engineering (CAE) capabilities of the Intergraph Engineering Modeling System coupled with the simulation capabilities of a locally developed three-dimensional boundary element code, BEPLATE. 1 ref., 7 figs
All the colours of the rainbow.
Our perception of colour has always been a source of fascination, so it's little wonder that studies of the phenomenon date back hundreds of years. What, though, can modern scientists learn from medieval literature — and how do we go about it
CURRENT POLICIES IN HEPATIC TRANSPLANTATION: CANDIDACY OF PATIENTS WITH ALCOHOLIC LIVER DISEASE OR PREFORMED ANTIDONOR ANTIBODIES AND A REAPPRAISAL OF BILIARY DUCT RECONSTRUCTION
Positive-Operator-Valued Time Observable in Quantum Mechanics
We examine the longstanding problem of introducing a time observable in
Quantum Mechanics; using the formalism of positive-operator-valued measures we
show how to define such an observable in a natural way and we discuss some
consequences.Comment: 13 pages, LaTeX, no figures. Some minor changes, expanded the
bibliography (now it is bigger than the one in the published version),
changed the title and the style for publication on the International Journal
of Theoretical Physic
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