136 research outputs found
Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort
Diet is a key factor for obesity development; however, limited data are available on
dietary cluster analysis in children with obesity. We aimed to assess the associations between dietary
patterns and obesity and several cardiometabolic markers. Anthropometry, bioelectrical impedance,
blood pressure and plasma biomarkers of oxidative stress, inflammation and endothelial damage
were determined in 674 Caucasian children, aged 5–16, with normal or excess weight. Using a food
frequency questionnaire and cluster analysis, two consistent dietary patterns were shown, labeled as
health conscious (HC) and sweet and processed (SP). The HC pattern included a greater proportion of
participants with overweight/obesity than the SP cluster (80.1% vs. 63.8%). However, children with
obesity within the HC cluster, showed less abdominal fat, through waist to hip (0.93 vs. 0.94) and
waist to height (0.61 vs. 0.63) indexes (p < 0.01). Univariate general models showed several additional
di erences in cardiometabolic risk biomarkers in the global and stratified analyses, with a healthier
profile being observed mainly in the HC cluster. However, multivariate models questioned these
findings and pointed out the need for further studies in this field. Anyhow, our findings support the
benefits of a healthy diet and highlight the importance of dietary patterns in the cardiometabolic risk
assessment of children with overweight/obesity, beyond weight control.Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER)
PI05/1968
PI11/01425
PI11/02042
PI11/02059
PI16/01301
PI16/01205
PI1600871CIBEROBN Network
CB15/00131
CB15/00043Juan de la Cierva-Formacion from the Spanish Government
FJCI-2017-34967
FJCI-2014-19795Vice-Rectorate of Research and Transfer of the University of Granada, Spai
Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic
inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we
aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during
puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and
inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein
(CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total
plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion
molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed.
Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in
comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and
tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in
those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43).
Conclusion: Those with obesity with higher prepubertal tPAI plasma levels had 19% higher odds of having MetS at puberty
highlighting the existence of association between MetS, obesity, and inflammation already in puberty. Thus, assessing cardiometabolic
and inflammatory status in children with obesity already at prepuberty is key to avoiding future comorbidities.CRUE-CSIC agreementSpringer NaturePlan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research PI11/01425
PI11/02042
PI11/02059
PI16/01301
PI16/01205
PI16/00871
PI20/00563CIBEROBN Network CB15/00131
CB15/00043Redes tematicas de investigacion cooperativa RETIC Red SAMID RD12/0026/001
The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
This work was supported by the Plan Nacional de Investigación Científica, Desarrollo e
Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS
FEDER) (PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563);
CIBEROBN Network (CB15/00131, CB15/00043); Redes temáticas de investigación cooperativa
RETIC (Red SAMID RD12/0026/0015). The authors also acknowledge Instituto de Salud Carlos
III for personal funding: Contratos i-PFIS: doctorados IIS-empresa en ciencias y tecnologías de la
salud de la convocatoria 2017 de la Acción Estratégica en Salud 2013–2016 (IFI17/00048). E.M.G.-G.
holds a Juan de la Cierva-Formación grant (FJCI-2017-34967) from the Ministerio de Ciencia e
Innovación (Spanish Government). L.V.P. acknowledges financial support of the Visiting Professor
Program from the Coordination for the Improvement of Higher Education Personnel (CAPES—Grant
88881.337237/2019-01), Brazil.Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4-12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight.Plan Nacional de Investigación Científica, Desarrollo e
Innovación Tecnológica (I + D + I)Instituto de Salud Carlos III-Health Research Funding (FONDOS
FEDER) (PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563)CIBEROBN Network (CB15/00131, CB15/00043)Redes temáticas de investigación cooperativa
RETIC (Red SAMID RD12/0026/0015)Instituto de Salud Carlos
III (IFI17/00048)Juan de la Cierva-Formación grant (FJCI-2017-34967) Ministerio de Ciencia e
Innovación (Spanish Government)Coordination for the Improvement of Higher Education Personnel (CAPES—Grant
88881.337237/2019-01), Brazi
LA LECTURA EN LOS ENTORNOS ELECTRÓNICOS EXPERIENCIA DE LA BIBLIOTECA UNIVERSITARIA / READING IN ELECTRONIC ENVIRONMENTS EXPERIENCE OF THE UNIVERSITY LIBRARY
En el trabajo se propone las experiencias relacionadas con la lectura en los formatos digitales a partir de la adquisición en la sala bibliotecaria de la Sede pedagógica, “Félix Varela”, de la Universidad Central Marta Abreu de Las Villas (UCLV) de los E-Readers que permiten presentar a los estudiantes, docentes y bibliotecarios, la novedad de leer, desde un dispositivo electrónico, en la sociedad de la información caracterizada por ser dinámica y cambiante. Se muestran además, las características que ofrecen estos lectores en su relación con el aprendizaje permanente, como una opción para incrementar el acceso a la bibliografía deficitaria que tienen determinadas carreras, en los fondos de la biblioteca. Se sustenta, que la lectura digital contribuye al desarrollo de las destrezas hábitos, actitudes y conocimientos que capacitan a las personas para estar, moverse, intervenir, actuar, aprender e interrelacionarse en el espacio electrónico
Usual Dietary Intake, Nutritional Adequacy and Food Sources of Calcium, Phosphorus, Magnesium and Vitamin D of Spanish Children Aged One to <10 Years. Findings from the EsNuPI Study †
The authors would like to thank IPN for its support and technical advice.Bone problems in the population begin to be establish in childhood. The present study
aims to assess the usual calcium, phosphorus, magnesium, and vitamin D intakes, along with the
food sources of these nutrients, in Spanish children participating in the EsNuPI (Estudio Nutricional
en Población Infantil Española) study. Two 24 h dietary recalls were applied to 1448 children (1 to <10 years) divided into two sub-samples: one reference sample (RS) of the general population
[n = 707] and another sample which exclusively included children consuming enriched or fortified
milks, here called “adapted milks” (AMS) [n = 741]. Estimation of the usual intake shows that
nutrient intake increased with age for all nutrients except vitamin D. Using as reference the Dietary
Reference Values from the European Food Safety Authority (EFSA), calcium and magnesium intakes
were found to be below the average requirement (AR) and adequate intake (AI), respectively, in a
considerable percentage of children. Furthermore, phosphorus exceeded the AI in 100% of individuals
and vitamin D was lower than the AI in almost all children studied. The results were very similar
when considering only plausible reporters. When analyzing the food sources of the nutrients studied,
milk and dairy products contributed the most to calcium, phosphorus, magnesium, and vitamin
D. Other sources of calcium were cereals and vegetables; for phosphorus: meat, meat products,
and cereals; for magnesium: cereals and fruits; and, for vitamin D: fish and eggs. These results
highlight the desirability of improving the intake concerning these nutrients, which are involved in
bone and metabolic health in children. The AMS group appeared to contribute better to the adequacy
of those nutrients than the RS group, but both still need further improvement. Of special interest are
the results of vitamin D intakes, which were significantly higher in the AMS group (although still
below the AI), independent of age.Instituto Puleva de Nutricion (IPN
EL DESEMPEÑO PROFESIONAL DE LOS BIBLIOTECARIOS PARA LA GESTIÓN DE INFORMACIÓN / THE PROFESSIONAL PERFORMANCE OF LIBRARIANS FOR INFORMATION MANAGEMENT
Este artículo ofrece temas sobre gestión de la información para perfeccionar el desempeño profesional en bibliotecarios de la provincia Villa Clara a través de video tutoriales, que detallan paso a paso el trabajo con las principales fuentes académicas y científicas en línea, sitios académicos en internet para la búsqueda y recuperación de la información, cómo realizar bibliotecas personales digitalizadas para la organización de la información y el asentamiento de las referencias bibliográficas según normas internacionales al confeccionar un trabajo investigativo y finalmente como efectuar su comunicación escrita y oral. El principal motivo de la elección de estos temas es la constante presencia de las tecnologías de la información y las comunicaciones (TIC) tanto en las actividades técnicas realizadas por los bibliotecarios, como a nivel de usuario y el hecho de que pueden satisfacer diversas necesidades informativas a través de herramientas como las redes sociales y las aplicaciones. Con relación a los métodos empleados se utilizó el análisis documental, principalmente de artículos consultados en línea, ya que la información referente a las TIC se encuentra en una gran proporción en este tipo de fuentes, se procedió a la revisión de bibliografía encontrada, principalmente referida a la parte de gestión de la información
Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease
Introduction: Parkinson's disease (PD) is characterized by the accumulation of abnormal a-synuclein in selected regions of the brain following a gradient of severity with disease progression. Whether this is accompanied by globally altered protein synthesis is poorly documented. The present study was carried out in PD stages 1-6 of Braak and middle-aged (MA) individuals without alterations in brain in the substantia nigra, frontal cortex area 8, angular gyrus, precuneus and putamen. Results: Reduced mRNA expression of nucleolar proteins nucleolin (NCL), nucleophosmin (NPM1), nucleoplasmin 3 (NPM3) and upstream binding transcription factor (UBF), decreased NPM1 but not NPM3 nucleolar protein immunostaining in remaining neurons; diminished 18S rRNA, 28S rRNA; reduced expression of several mRNAs encoding ribosomal protein (RP) subunits; and altered protein levels of initiation factor eIF3 and elongation factor eEF2 of protein synthesis was found in the substantia nigra in PD along with disease progression. Although many of these changes can be related to neuron loss in the substantia nigra, selective alteration of certain factors indicates variable degree of vulnerability of mRNAs, rRNAs and proteins in degenerating sustantia nigra. NPM1 mRNA and 18S rRNA was increased in the frontal cortex area 8 at stage 5-6; modifications were less marked and region-dependent in the angular gyrus and precuneus. Several RPs were abnormally regulated in the frontal cortex area 8 and precuneus, but only one RP in the angular gyrus, in PD. Altered levels of eIF3 and eIF1, and decrease eEF1A and eEF2 protein levels were observed in the frontal cortex in PD. No modifications were found in the putamen at any time of the study except transient modifications in 28S rRNA and only one RP mRNA at stages 5-6. These observations further indicate marked region-dependent and stage-dependent alterations in the cerebral cortex in PD. Altered solubility and a-synuclein oligomer formation, assessed in total homogenate fractions blotted with anti-a-synuclein oligomer-specific antibody, was demonstrated in the substantia nigra and frontal cortex, but not in the putamen, in PD. Dramatic increase in a-synuclein oligomers was also seen in fluorescent-activated cell sorter (FACS)-isolated nuclei in the frontal cortex in PD. Conclusions: Altered machinery of protein synthesis is altered in the substantia nigra and cerebral cortex in PD being the frontal cortex area 8 more affected than the angular gyrus and precuneus; in contrast, pathways of protein synthesis are apparently preserved in the putamen. This is associated with the presence of alpha-synuclein oligomeric species in total homogenates; substantia nigra and frontal cortex are enriched, albeit with different band patterns, in alpha-synuclein oligomeric species, whereas alpha-synuclein oligomers are not detected in the putamen
Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43)Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563); CIBEROBN Network (CB15/00131, CB15/00043); and Redes temáticas de investigación cooperativa RETIC (Red SAMID RD12/0026/0015)S
Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study
Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43)Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205, PI16/00871 and PI20/00563); CIBEROBN Network (CB15/00131, CB15/00043); and Redes temáticas de investigación cooperativa RETIC (Red SAMID RD12/0026/0015)S
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