Nonsmooth Morse-Sard theorems

We prove that every function $f:\mathbb{R}^n\to \mathbb{R}$ satisfies that the image of the set of critical points at which the function $f$ has Taylor expansions of order $n-1$ and non-empty subdifferentials of order $n$ is a Lebesgue-null set. As a by-product of our proof, for the proximal subdifferential $\partial_{P}$, we see that for every lower semicontinuous function $f:\mathbb{R}^2\to\mathbb{R}$ the set $f(\{x\in\mathbb{R}^2 : 0\in\partial_{P}f(x)\})$ is $\mathcal{L}^{1}$-null.Comment: Final version. The main result has been strengthened thanks to the suggestions of a refere

One hundred of cells generations connect the resistance to drugs and the replicative aging mechanisms

There are researchs that reveal a relationship between acquired resistance to antineoplastic drugs and aging. Therefore, the identification of genes involved in senescence could have a potential therapeutic utility for the prediction and/or prevention of resistance to antineoplastic drugs. The aim of this work is to study the relationship between replicative aging and acquired resistance to Cisplatin and Bleomycin in the yeast Saccharomyces cerevisiae.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

New markers of bleomycin resistance

Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment. The aim of this work is to carry out a proteomic analysis in the wild type strain and bleomycin resistant strain of Saccharomyces cerevisiae in order to look for possible markers of resistance, as well as the mechanisms involved.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae

Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance. This mechanism could explain the tumor resistance observed in chemotherapy treatments with multiple agents. The aim of this work is to study possible mechanisms of cross resistance between Cisplatin and Bleomycin in Saccharomyces cerevisiae.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Proteomic analysis in wild type and cisplatin resistant yeast strain of saccharomyces cerevisiae

Research carried out in oncology has allowed the identification and characterization of molecular markers of resistance to antineoplastic drugs. It supposes a great advance and allows the administration of customized chemotherapies to patients. The aim of this work is to carry out a proteomic analysis in the wild type strain and cisplatin resistant strain of Saccharomyces cerevisiae in order to look for possible markers of resistance, as well as the mechanisms involved.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

[Review of] James P. Danky and Wayne A. Wiegand, eds. Print Culture in a Diverse America. The History of Communication Series

This volume functions both in illuminating minority perspectives in print culture and describing and furthering the field of print culture studies. The introduction then both discusses the structure and purpose of the field and argues that the book\u27s contents challenge it in a variety of ways. Three thematic sections follow which cover, respectively, lost serials, the publishing industry, and written reconstructions of historical events

Resistance to bleomycin increases the chronological life of cells

The identification of genes involved in chronological aging could have a potential utility as molecular markers in the chemotherapy treatment of cancer. The aim of this work is to study the relationship between the chronological aging and the resistance to Bleomycin for the purpose of establish the basic interactions between these phenomenons for further investigation of molecular markers.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Fungal endophytes in species of paspalum and bromus, occurrence and in vitro antagonistic activity assessment

The aims of this work were to study the occurrence of fungiassociated to Paspalum dilatatum, P. notatum, Bromus biebersteiniiand B. catharticus and to evaluate their potential as antagonisticagents against fungal pathogens. The genera Acremonium, Alternaria,Aspergillus, Curvularia, Fusarium, Penicillium and Stemphylium werethe most representative isolated fungi. The isolates of the genusAcremonium showed antagonistic activity against different putativepathogenic species tested in dual cultures. The results suggest that theinteractions and mechanisms of antagonism of the same strain varyaccording to the putative pathogenic strains to which they are facedto. The results encourage further studies to elucidate if the strainsisolated in this study are good candidates for biological control of latentpathogens in pastures. To accomplish this, future studies focused onthe analysis of the secondary metabolites produced by the antagonistsin the culture medium, as well as assays in planta will be conducted.Fil: García Lemos, Adriana. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias; ArgentinaFil: Gil Cardeza, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones en Ciencias Agrarias de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias. Instituto de Investigaciones en Ciencias Agrarias de Rosario; ArgentinaFil: Gomez, Elena del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones en Ciencias Agrarias de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias. Instituto de Investigaciones en Ciencias Agrarias de Rosario; ArgentinaFil: Felitti, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones en Ciencias Agrarias de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias. Instituto de Investigaciones en Ciencias Agrarias de Rosario; Argentin

Resistance acquisition after seven cycles of in vitro bleomycin exposure

Bleomycin is an antineoplastic drug that causes DNA damage by intra- and inter-strand crosslink and DNA strand breaks. This drug is used to treat several types of cancer. The aim of this work is to study the effect of Bleomycin on S. cerevisiae cells and select bleomycin-resistant cells to study the process of resistance acquisition to establish new protocols in in vitro drugs exposure.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech