The Beneficial Effects of Supplemental Vitamins C and E in Diabetic Subjects

Few reviews have been written related to the benefits of supplementing vitamin C and E in diabetic individuals. Excessive protein glycosylation is seen in persons with diabetes, and vitamin E and C have been shown to be beneficial in decreasing the glycosylation of proteins. In addition, vitamins E and Care potent antioxidants and actively reduce oxidation, triglycerides, and free fatty acid levels in diabetics. Diabetics may benefit from supplementing vitamins E and C

UX Approaches for Museum Contexts: Evaluating a Museum's Participatory Elements

Our research applies UX principles and scholarship to museum design in order to provide these institutions with tools that they can use to evaluate the effectiveness of their existing participatory elements, implement new participatory practices, and provide visitors with interactive experiences. After conducting observations and cataloging participatory elements in the MSU Museum, as well as reviewing relevant UX scholarship from Norman (2013), Shirky (2008), Simon (2010), Spinuzzi (2005), and others who have talked about participation and experience design, we created two documents: a definition guide and an evaluation form. Using the documents, we created and museum contexts as an example, we explain that UX concepts can be broadly applied to other industries in order to inform participation practices. The main takeaway from our research is that UX terms and concepts are flexible enough to be applied to multiple industries in order to improve the effectiveness of an organization or institution's current participatory elements and help them reach their goals regarding user participation

Women Proudly Roaring Their Feminist Ideas

https://digitalcommons.chapman.edu/feminist_zines/1051/thumbnail.jp

Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

BACKGROUND: Iron binding, naturally occurring protein bovine lactoferrin (bLf) has attracted attention as a safe anti-cancer agent capable of inducing apoptosis. Naturally, bLf exists partially saturated (15-20%) with Fe(3+) however, it has been demonstrated that manipulating the saturation state can enhance bLf\u27s anti-cancer activities. METHODS: Apo-bLf (Fe(3+) free) and Fe-bLf (>90% Fe(3+) Saturated) were therefore, tested in MDA-MB-231 and MCF-7 human breast cancer cells in terms of cytotoxicity, proliferation, migration and invasion. Annexin-V Fluos staining was also employed in addition to apoptotic protein arrays and Western blotting to determine the specific mechanism of bLf-induced apoptosis with a key focus on p53 and inhibitor of apoptosis proteins (IAP), specifically survivin. RESULTS: Apo-bLf induced significantly greater cytotoxicity and reduction in cell proliferation in both cancer cells showing a time and dose dependent effect. Importantly, no cytotoxicity was detected in normal MCF-10-2A cells. Both forms of bLf significantly reduced cell invasion in cancer cells. Key apoptotic molecules including p53, Bcl-2 family proteins, IAP members and their inhibitors were significantly modulated by both forms of bLf, though differentially in each cell line. Most interestingly, both Apo-bLf and Fe-bLf completely inhibited the expression of survivin protein (key IAP), after 48 h at 30 and 40 nM in cancer cells. CONCLUSIONS: The capacity of these forms of bLf to target survivin expression and modulation of apoptosis demonstrates an exciting potential for bLf as an anti-cancer therapeutic in the existing void of survivin inhibitors, with a lack of successful inhibitors in the clinical management of cancer

Climate resilience for health care and communities: Strategies and case studies

This report provides a strategic framework for building truly climate-resilient health systems and communities, and explores how health care institutions can leverage investments to support equitable decarbonization and build community resilience, health, and wealth. Through case studies, this paper outlines actions health systems can take to improve their ability to adapt and recover from climate-driven service impacts, strengthen long-term sustainability, and support health and equity in the communities they serve

Barriers to effective feedback: Student and Staff perspectives

This study aimed to understand how staff and students in a large Biomedical Sciences course conceive of feedback, and to examine existing barriers to effective feedback practices. Students (n = 1003) and Teaching Associates (n = 57; TAs) were anonymously surveyed about their views. Biomedicine academic staff (n = 5) and students (n = 3) participating in semi-structured interviews to expand on key themes. Participants expressed a traditional view of feedback as a ‘transmissive’ process. Within this view, they each identified different but interrelated barriers to effective feedback. In addition to logistical concerns of large cohorts, staff reported a lack of confidence in the TAs ability to provide feedback. This was also reflected in TAs reporting that they are not confident in providing ‘critical’ comments as they view students lack resilience and openness to feedback. Students reported that feedback on their work didn’t adequately, or personally address how they could improve. They also indicated a lack of opportunities to receive and utilise feedback. Academics and students identified that the majority of feedback in the course was relegated to summative feedback; disconnected from subsequent learning experiences. Together, these factors exemplify a series of misconnections reducing the capacity to practice effective feedback

Virtual physiology laboratories during a pandemic: Are they effective for student learning compared to in-person laboratories?

BACKGROUND COVID-19 has significantly impacted higher education, including rapidly transitioning interactive, in-person laboratories to virtual settings. Human physiology laboratories, emphasised in hands-on, active learning, have been particularly impacted by these changes. THE INITIATIVE We assessed whether virtual laboratories are effective in achieving similar student learning outcomes as in-person laboratories, namely in students’ conceptual understanding, research and technical skills development. METHODS Students were randomly assigned to either an in-person or virtual laboratory. The in-person laboratory provided students with hands-on experience in data collection and analysis, while the virtual laboratory included a self-directed module, guiding students through the same series of experiments using pre-recorded videos and data. Pre- and post- surveys were used to assess differences in students’ conceptual understanding, and self-reported ratings of confidence in research and technical skills. OUTCOMES Both groups demonstrated significantly improved performance on conceptual- and research-based multiple-choice questions. The in-person group performed significantly better on application-based, short-answer questions, and rated significantly greater confidence in their technical skills. No significant differences were observed on self-reported ratings of student confidence in research and technical skills. Our findings highlight the importance in identifying pedagogical approaches which focus on developing students’ ability and confidence in technical and research skills within virtual settings

Exploring anti-PD-1 resistance mechanisms for therapeutic targeting in NSCLC

View full abstracthttps://openworks.mdanderson.org/leading-edge/1035/thumbnail.jp

Attitudes and perceptions about ecological resources and hazards of people living around the Savannah River Site

Although considerable attention is devoted to environmental monitoring and assessment with respect to both pollutants and the status of particular plant or animal populations, less attention is devoted to assessing people\u27s attitudes about the relative importance of ecological resources. In this paper we examine the attitudes and perceptions about ecological resources of people living around the Department of Energy\u27s Savannah River Site (SRS), in South Carolina. Our overall hypothesis is that people who are directly affected by the possible outcomes and consequences of a particular hazard (i.e., those people employed at SRS) will undervalue the risks and overvalue the potential benefits from future land uses that favour continued site activity, compared to people who live near but are not employed at SRS. We interviewed 286 people attending the Aiken Trials horse show on 14 March 1997. There were few gender differences, although men hunted and fished more than women, women ranked three environmental concerns as more severe than did men, and women were more concerned about the effect of SRS on property values. Maintenance of SRS as a National Environmental Research Park ranked first as a future land use; nuclear production ranked second, followed by hunting and hiking. Only residential development ranked very low as a future land use. There were many differences as a function of employment history at SRS: (1) people who work at SRS think that the federal government should spend funds to clean up all nuclear facilities, and they think less money should be spent on other environmental problems than did non-employees, (2) people who work at SRS ranked continued current uses of SRS higher than did people who never worked at SRS, and (3) people who work at SRS are less concerned about the storage of nuclear material or accidents at the site than are people who never worked at the site