1 research outputs found
Lipoic-Based TRPA1/TRPV1 Antagonist to Treat Orofacial Pain
Inflammation of the
trigeminal nerve is considered one of the most
painful conditions known to humankind. The diagnosis is often difficult;
moreover, safe and effective pharmacological treatments are lacking.
A new molecule, ADM_12, formed by a lipoic and omotaurine residues
covalently linked, is here reported. In vitro and in vivo tests showed
that ADM_12 is a very attractive original compound presenting (i)
a remarkable safety profile; (ii) a high binding constant versus TRPA1;
(iii) an intriguing behavior versus TRPV1; and (iv) the ability to
significantly and persistently reduce mechanical facial allodynia
in rats. Noteworthy, by testing ADM_12, we shed light on the unprecedented
involvement of TRPA1 and TRPV1 channels in orofacial pain