La terra ai forestieri

Nel tempo in cui migliaia di europei lasciavano la propria terra di origine per gettarsi alla conquista del mondo svelato dalle grandi esplorazioni geografiche, i poteri pubblici del Vecchio Continente si impegnavano a ripopolare i rispettivi territori stanziandovi coloni forestieri. Questo libro racconta la colonizzazione interna dell’Europa attraverso otto storie di cui furono protagonisti uomini e donne provenienti da alcune grandi diaspore mediterranee. Esuli, migranti, forestieri, che dalla Toscana granducale alle spagnole Sicilia e Sardegna, dalla Napoli dei viceré alla Venezia dei dogi, dalla Spagna borbonica fino all'Austria della “reconquista” anti-ottomana, contribuirono alla formazione dell’Europa contemporanea

¿Qué es la gramaticografía? Maestros, proyectos, estudios

Il volume presenta la grammaticografia come disciplina storiografica, cos'è, a cosa serve, chi sono i suoi maestri, quali sono i progetti attuali più importanti e quali sono i modelli di articoli più frequenti.The volume presents grammarography as a discipline of historiography, what it is, what it is for, who are its masters, what are the most important current projects and what are the most frequent models of study.El volumen presenta la gramaticografía como disciplina de la historiografía, qué es, para qué sirve, quiénes son sus maestros, cuáles son los proyectos actuales más importantes y cuáles son los modelos de estudios más frecuentes

"Zone Moda Journal", numero monografico su "Fashion and Well-Being", n. 4, 2014

Questo fascicolo monografico della rivista "Zone Moda Journal" \ue8 dedicato al rapporto tra moda e ben-essere, tema di tendenza nel campo degli studi culturali. L'argomento viene affrontato in una prospettiva multidisciplinare, per comporre una riflessione inedita e poliedrica sul motivo del well-being inteso come equilibrio e salute dell'individuo nella sua integrit\ue0, pratica del buon vivere che si propone di congiungere l'estetica all'etica al di l\ue0 del semplice concetto di wellness, secondo un concetto innovativo non solo nel campo della moda, ma della cultura in generale

A new dynamical modeling of the WASP-47 system with CHEOPS observations

Among the hundreds of known hot Jupiters (HJs), only five have been found to have companions on short-period orbits. Within this rare class of multiple planetary systems, the architecture of WASP-47 is unique, hosting an HJ (planet-b) with both an inner and an outer sub-Neptunian mass companion (-e and -d, respectively) as well as an additional non-transiting, long-period giant (-c). The small period ratio between planets -b and -d boosts the transit time variation (TTV) signal, making it possible to reliably measure the masses of these planets in synergy with the radial velocity (RV) technique. In this paper, we present new space- and ground-based photometric data of WASP-47b and WASP-47-d, including 11 unpublished light curves from the ESA mission CHaracterising ExOPlanet Satellite (CHEOPS). We analyzed the light curves in a homogeneous way together with all the publicly available data to carry out a global N-body dynamical modeling of the TTV and RV signals. We retrieved, among other parameters, a mass and density for planet -d of Md = 15.5 ± 0.8 M⊕ and ρd = 1.69 ± 0.22 g cm−3, which is in good agreement with the literature and consistent with a Neptune-like composition. For the inner planet (-e), we found a mass and density of Me = 9.0 ± 0.5 M⊕ and ρe = 8.1 ± 0.5 g cm−3, suggesting an Earth-like composition close to other ultra-hot planets at similar irradiation levels. Though this result is in agreement with previous RV plus TTV studies, it is not in agreement with the most recent RV analysis (at 2.8σ), which yielded a lower density compatible with a pure silicate composition. This discrepancy highlights the still unresolved issue of suspected systematic offsets between RV and TTV measurements. In this paper, we also significantly improve the orbital ephemerides of all transiting planets, which will be crucial for any future follow-up.ISSN:0004-6361ISSN:1432-074

Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion

Introduction: Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. PAM encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides.Methods: Following the identification of a loss-of-function variant (p.Arg703Gln) in the peptidylglycine a-amidating monooxygenase (PAM) gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated PA kindreds for PAM variants. Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis.Results: In germline DNA, we detected seven heterozygous, likely pathogenic missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with growth hormone excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T>C and p.His778fs), or different types of PAs (c.-361G>A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested in vitro for protein expression and trafficking by Western blotting, splicing by minigene assays, and amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the PAM gene and rare PAM SNVs with diagnoses linked to pituitary gland hyperfunction.Conclusion: The identification of PAM as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.ISSN:1664-239