Elastoplastic Damaging Model for Adhesive Anchor Systems. I: Theoretical Formulation and Numerical Implementation

In this and in the companion paper, the mechanical response of adhesive anchor systems is theoretically and numerically predicted and experimentally observed. The theoretical prediction is on the basis of an elastoplastic damaging model formulated to predict the structural response associated with the development of a fracture in adhesive anchor systems. This part describes the analytical model developed in the framework of a thermodynamically consistent theory, which assumes adhesion where the structure is sound, and friction in correspondence with the fracture. Isotropic damage is considered. The model can predict the structural behavior at the interface between two surfaces of ductile, brittle, or quasi-brittle materials. The Helmholtz free energy is written to model the materials' hardening or softening. Isotropic damage is considered, and the possible effects of dilatancy are taken into account, including nonassociative flow rules. The formulation is implemented into the finite-element code FEAP. In the companion paper, the new model is adopted to predict the mechanical response to the pullout force of postinstalled rebar chemically bonded in concrete. The analytical model and the numerical implementation are experimentally validated by several pullout tests, which are monitored by using an acoustic-emission technique

Adnexal Torsion in Pediatric Age: Does Bolli's Score Work? Report of Two Cases

Adnexal torsion is a surgical emergency requiring early diagnosis in order to avoid demolitive surgery. Adnexal torsion's diagnosis could be very difficult in pediatric patients because children cannot explain symptoms accurately. Furthermore reproductive organs lie high in abdomen, causing unclear examinations findings. For reducing diagnostic mistakes or delay clinical and hematological criteria could be useful. No radiological criteria (CT or MRI) should be taken in count because of the costs and the required time. By combining clinical presentation in patients with OT three useful diagnostic variables have been identified: age, duration of pain, vomiting. Presence of vomiting, short duration of abdominal pain and high CRP levels have great predictive value for the diagnosis of adnexal torsion. In those patients an exploratory laparoscopy should be performed without any doubt and/or delay. These data may aid physicians in the evaluation of abdominal pain in premenarchal girls

VALUTAZIONE DELLA RESISTENZA DI ADESIONE E DELLA LUNGHEZZA EFFICACE DI INCOLLAGGIO NEI GIUNTI ADESIVI TRAMITE LE LEGGI DELL’EFFETTO SCALA

In recent years, growing attention has been paid by researchers in structural mechanics to bonded joints in order to provide theoretical and numerical tools for better understanding the interfacial bonding/debonding phenomena. The research efforts in this area regard the formulation of reliable bond-slip models based on experimental data coming from laboratory tests performed on small specimens [1, 2]. As reported in [3], the mechanical quantities characterizing any interface constitutive law can be derived from the results of the experimental pull tests by a simple procedure making use of a schematization of the structural problem. The application to some single lap joint tests, carried out at the DISAG Laboratory of Palermo University, shows the effectiveness of the procedure

INTERFACE MODEL FOR THE NONLINEAR ANALYSIS OF BLOCKY STRUCTURES OF ANCIENT GREEK TEMPLES

The presence of singularity surfaces with reference to the displacement field is a characteristic of a number of structural systems. Strong discontinuities are present in old masonry structures where dry joints connect the blocks or the mortar ageing suggests to neglect the adhesion properties. These structures cannot be considered a continuum but rather an assembly of blocks. These discontinuous structures could be modelled as an assembly of blocks interacting trough frictional joints whose mechanical behaviour is described by appropriate interface laws. In the present work an interface model present in literature is adopted, the double asperity model, which has been implemented in a standard finite element code with the principal aim to develop structural analysis of old monumental masonry structures. The interface model is briefly illustrated and the numerical implementation of the interface laws is described in detail. Numerical examples are presented to simulate the behaviour of a couple of greek temples of Agrigento Italy. These old monumental structures, IV-VI sec. BC, are inserted in the world heritage list by Unesco

Elastoplastic Damaging Model for Adhesive Anchor Systems. II: Numerical and Experimental Validation

This paper presents the numerical and experimental validation of the analytical elastoplastic damaging model proposed in the companion paper (Part I). The validation was carried out by describing the pullout failure of epoxy adhesive anchors. Pullout tests were simulated numerically and performed experimentally. Several specimens made of a rebar embedded in a hardened concrete cylinder by means of polyester resin were tested. Conventional strain gauges and acoustic emission (AE) sensors were used to evaluate the structural response of the system and to monitor the onset and progression of structural damage, respectively. The parametric analysis and the moment tensor analysis of the AE data were used to discriminate among different sources of damage. The results show the ability of the model to predict the response of the anchors and the suitability of the AE method to monitor damage onset and propagation and to discriminate among different source of damage

S-100 protein, but not calmodulin, binds to the glial fibrillary acidic protein and inhibits its polymerization in a Ca(2+)-dependent manner.

S-100 protein, a Ca(2+)-binding protein of the EF-hand type, interacts with the glial fibrillary acidic protein (GFAP) in a Ca(2+)-dependent manner. The binding of S-100 protein to GFAP was investigated by fluorescence spectroscopy using acrylodan-S-100 protein and cross-linking experiments using the bifunctional cross-linker, disuccinimidyl suberate. The binding affinity was observed to be in the nanomolar range with a stoichiometry of 2 mol of GFAP/mol of S-100 protein (dimer). S-100 protein was found to inhibit the polymerization of GFAP in a dose- and Ca(2+)-dependent manner, with a half-maximal effect at an S-100 protein/GFAP molar ratio of 0.2 and maximal effect at a molar ratio of 0.5. Identical results were obtained irrespective of whether the unfractionated bovine brain S-100 protein mixture (S-100a plus S-100b), S-100ao, S-100a, or S-100b was used. S-100 protein was observed to be maximally effective as an inhibitor of GFAP polymerization at approximately 3 microM free Ca2+. Calmodulin neither bound to GFAP nor inhibited its polymerization. Altogether, the present results suggest that S-100 protein might be involved in the regulation of the state of assembly of glial filaments by binding to and sequestering unpolymerized GFAP