Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving "diversity with ease", by combining classic C-C π-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels-Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates-demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.Christopher J. Smedley, Gencheng Li, Andrew S. Barrow, Timothy L. Gialelis, Marie-Claire Giel, Alessandra Ottonello, Yunfei Cheng, Seiya Kitamura, Dennis W. Wolan, K. Barry Sharpless, and John E. Mose

Guidelines for diverse citizen science recruitment

Abstract The CSI-COP project will engage citizen scientists to investigate GDPR compliance through exploring cookies in websites and in apps. This document is the second of two deliverables in CSI-COP project work package 2 (WP2) that investigate the best practices that have been used Europe-wide and in international citizen science projects. The previous deliverable D2.1 conducted an exhaustive exploration of literature in order to find the best practices and the most efficient methods in citizen science engagement (CSI-COP, 2020). In the present deliverable D2.2 we explore the means that have been adopted to achieve balanced and diverse participation in citizen science, taking into consideration gender, socio-economic and geographic factors. To this end, we covered three main factors affecting inclusive citizen science projects, and we present our findings in this report. First, we review a large number of citizen science projects regarding the demographic and socio-economic characteristics of their participants and we draw conclusions about the typical characteristics of those involved in such activities. Secondly, we describe in detail the digital divide phenomenon and its effects on the social participation of different individuals and groups. Finally, we present the diversity factors that influence participation in citizen science projects and explain the identified methods to access different target audiences

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving "diversity with ease" by combining classic C-C �-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the stereoselective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels-Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates-demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin

CSI-COP framework for engaging citizen scientists

Abstract This document provides the framework for the optimum method of applying ECSA’s (European Citizen Science Association) ten principles of citizen science engagement for quality assurance in ethical and inclusive citizen science engagement in the CSI-COP project for the purposes of investigating the extent of online tracking. Following a dynamic recruitment drive, a diverse community of citizen scientists will gain new knowledge and practical skills through informal education provided in workshops and a MOOC (massive open online course). The expertise gained will provide an impetus to join the CSI-COP project collaborating with researchers investigating compliance of General Data Protection Regulation (GDPR) on websites and in apps. A series of activities, validating the outcomes of CSI-COP’s citizen scientists, will be essential to ensure the accuracy of the exploration and findings of cookies embedded in websites and in mobile device apps

Public report on current methods in CS Engagement CSI-COP EU H2020 project (Report D2.1, CSI-COP)

Abstract CSI-COP deliverable D2.1 is a public research report realised from the exhaustive literature review conducted for Task 2.1 by the involved partners in the research phase of the EU Horizon2020 science with and for society (SwafS) project Citizen scientists investigating cookies and app GDPR compliance (CSI-COP). With the report produced from the next T2.2 research task, deliverable D2.2 (due M06), D2.1 will lead to the development of CSI-COP project’s framework for best practices in inclusive citizen science recruitment and engagement