"I cannot stand the boredom." Binge drinking expectancies in adolescence

Introduction: The main aim of this study is to improve our knowledge on binge drinking behavior in adolescents. In particular, we tested a model of predictors of binge drinking focusing on boredom proneness; we also examined the predictive and mediating role of drinking expectancies on binge drinking. Methods: A questionnaire designed to assess current drinking behavior, such as binge drinking, drinking expectancies and boredom proneness, was administered to 721 Italian adolescents (61% females) aged between 13 and 19 years (M = 15.98, SD = 1.61). Results: Structural equation modeling confirmed the evidence on drinking expectancies as predicted by boredom proneness and as predictive of adolescents' binge drinking. Interestingly, disinhibition and relief from pain seem to play a more important mediating role between boredom and alcohol outcome. Conversely, no mediation was found for interpersonal and social confidence expectancies on binge drinking. Conclusions: In general, the results suggest that preventative interventions on alcohol misuse should focus on personality traits and underlying drinking expectancies

A compact ultranarrow high-power laser system for experiments with 578nm Ytterbium clock transition

In this paper we present the realization of a compact, high-power laser system able to excite the Ytterbium clock transition at 578 nm. Starting from an external-cavity laser based on a quantum dot chip at 1156 nm with an intra-cavity electro-optic modulator, we were able to obtain up to 60 mW of visible light at 578 nm via frequency doubling. The laser is locked with a 500 kHz bandwidth to a ultra-low-expansion glass cavity stabilized at its zero coefficient of thermal expansion temperature through an original thermal insulation and correction system. This laser allowed the observation of the clock transition in fermionic $^{173}$Yb with a < 50 Hz linewidth over 5 minutes, limited only by a residual frequency drift of some 0.1 Hz/s

Possible future monoclonal antibody (mAb)-based therapy against arbovirus infections

More than 150 arboviruses belonging to different families are known to infect humans, causing endemic infections as well as epidemic outbreaks. Effective vaccines to limit the occurrence of some of these infections have been licensed, while for the others several new immunogens are under development mostly for their improvements concerning safety and effectiveness profiles. On the other hand, specific and effective antiviral drugs are not yet available, posing an urgent medical need in particular for emergency cases. Neutralizing monoclonal antibodies (mAbs) have been demonstrated to be effective in the treatment of several infectious diseases as well as in preliminary in vitro and in vivo models of arbovirus-related infections. Given their specific antiviral activity as well-tolerated molecules with limited side effects, mAbs could represent a new therapeutic approach for the development of an effective treatment, as well as useful tools in the study of the host-virus interplay and in the development of more effective immunogens. However, before their use as candidate therapeutics, possible hurdles (e.g., Ab-dependent enhancement of infection, occurrence of viral escape variants) must be carefully evaluated. In this review are described the main arboviruses infecting humans and candidate mAbs to be possibly used in a future passive immunotherapy

Analytical psychodrama with college students suffering from mental health problems: Preliminary outcomes

The aim of this work was to assess the therapeutic efficacy of analytical psychodrama groups for college students with psychological problems. Analytical psychodrama, as a form of group psychotherapy, is an integral part of the program of treatment of young adults in the Counselling Center of the University of Bologna, which provides a free service for its students, aimed at delivering psychological support. Thirty patients (22 females) from 20 to 26 years old (mean age 22.33, standard deviation±1.75), suffering from mental health problems, who completed one year of psychodrama, were assessed before and after group psychotherapy. The Italian validation of Clinical Outcomes in Routine Evaluation – Outcome Measure was used as test-retest questionnaire for clinical outcome evaluation. The results demonstrated the efficacy of the treatment in terms of symptom decrease and improvement of patients’ well being. After the treatment (40 sessions, once a week), patients showed a statistically significant reduction in clinical outcomes scores compared with pre-treatment scores. Moreover, the analyses of Reliable and Clinical Significant Change index showed that about 30% of patients improved, and this improvement was reliable and/or clinically significant. Our preliminary findings revealed that analytical psychodrama is a suitable treatment for college students, as it actually reduces young adults’ symptoms. These results contribute to the topic of the validity of psychodrama interventions to encourage research regarding the specific psychotherapeutic effects of its method

Early histologic findings of pulmonary SARS-CoV-2 infection detected in a surgical specimen

Despite the current pandemic season, reports on pathologic features of coronavirus disease 19 (Covid-19) are exceedingly rare at the present time. Here we describe the pathologic features of early lung involvement by Covid-19 in a surgical sample resected for carcinoma from a patient who developed SARS-CoV-2 infection soon after surgery. The main histologic findings observed were pneumocyte damage, alveolar hemorrhages with clustering of macrophages, prominent and diffuse neutrophilic margination within septal vessels, and interstitial inflammatory infiltrates, mainly represented by CD8+ T lymphocytes. These features are similar to those previously described in SARS-CoV-2 infection. Subtle histologic changes suggestive pulmonary involvement by Covid-19 may be accidentally encountered in routine pathology practice, especially when extensive sampling is performed for histology. These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients

Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case

The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer

Regular wave seakeeping analysis of a planing hull by smoothed particle hydrodynamics: a comprehensive validation

In this work, the dynamics of a planing hull in regular head waves was investigated using the Smoothed Particle Hydrodynamics (SPH) meshfree method. The simulation of the interaction of such vessels with wave trains features several challenging characteristics, from the complex physical interaction, due to large dynamic responses, to the likewise heavy numerical workload. A novel numerical wave flume implemented within the SPH-based code DualSPHysics fulfills both demands, guaranteeing comparable accuracy with an established proprietary Computational Fluid Dynamics (CFD) solver without sharpening the computational load. The numerical wave flume uses ad hoc open-boundary conditions to reproduce the flow characteristics encountered by the hull during its motion, combining the current and waves while adjusting their properties with respect to the vessel’s experimental towing speed. It follows a relatively small three-dimensional domain, where the potentiality of the SPH method in modeling free-surface flows interacting with moving structures is unleashed. The results in different wave conditions show the feasibility of this novel approach, considering the overall good agreement with the experiments; hence, an interesting alternative procedure to simulate the seakeeping test in several marine conditions with bearable effort and satisfying accuracy is established.Ministerio de Ciencia e Innovación | Ref. PID2020-113245RBI00Xunta de Galicia | Ref. ED431C 2021/44Ministerio de Ciencia e Innovación | Ref. TED2021-129479AI00Xunta de Galicia | Ref. ED481A-2021/337Ministerio de Ciencia e Innovación | Ref. RYC2020-030197-

An Intraoperative β−\beta^- Detecting Probe For Radio-Guided Surgery in Tumour Resection

The development of the $\beta^-$ based radio-guided surgery aims to extend the technique to those tumours where surgery is the only possible treatment and the assessment of the resection would most profit from the low background around the lesion, as for brain tumours. Feasibility studies on meningioma, glioma, and neuroendocrine tumors already estimated the potentiality of this new treatment. To validate the technique, prototypes of the intraoperative probe required by the technique to detect $\beta^-$ radiation have been developed. This paper discusses the design details of the device and the tests performed in laboratory. In such tests particular care has to be taken to reproduce the surgical field conditions. The innovative technique to produce specific phantoms and the dedicated testing protocols is described in detail.Comment: 7 pages, 15 figure