Aortic aneurysm and non-Hodgkin’s lymphoma in Marfan syndrome

The combination of Marfan syndrome with lymphoma is extremely rare. This report describes a case of Marfan syndrome who presented with chest discomfort and was diagnosed to have an aortic aneurysm and an additional incidental mediastinal mass that on further investigation turned out to be a diffuse large B cell lymphoma. We have suggested a hypothesis which can explain the occurrence of lymphoma in Marfan syndrome

Probing the NMSSM via Higgs boson signatures from stop cascade decays at the LHC

Higgs signatures from the cascade decays of light stops are an interesting possibility in the next to minimal supersymmetric standard model (NMSSM). We investigate the potential reach of the light stop mass at the 13 TeV run of the LHC by means of five NMSSM benchmark points where this signature is dominant. These benchmark points are compatible with current Higgs coupling measurements, LHC constraints, dark matter relic density and direct detection constraints. We consider single and di-lepton search strategies, as well as the jet-substructure technique to reconstruct the Higgs bosons. We find that one can probe stop masses up to 1.2 TeV with 300 $\rm fb^{-1}$ luminosity via the di-lepton channel, while with the jet-substructure method, stop masses up to 1 TeV can be probed with 300 $\rm fb^{-1}$ luminosity. We also investigate the possibility of the appearance of multiple Higgs peaks over the background in the fat-jet mass distribution, and conclude that such a possibility is viable only at the high luminosity run of 13 TeV LHC.Comment: 20 pages, 5 figures; Two figures updated, typos corrected. Matched with the published versio

Remodeling of the antegonial angle region in the human mandible : a panoramic radiographic cross-sectional study

Objectives: This study analyzed changes in the antegonial region in relation to age, gender, and dental status. Study design: A total of one thousand patients (five hundred males and five hundred females), who were prescribed panoramic radiograph for various purposes were included in the study. The patients were categorized according to age, gender and dentition status. Panoramic radiographs were traced and antegonial angles and depths were measured. Results: A trend of decrease in the antegonial angle and increase in antegonial depth with age was observed in both males and females. Furthermore there were differences between right and left side antegonial angle and depth, with left side angle more than right and right side depth more than left. There was a significant decrease in the values of antegonial angle and significant increase in the values of antegonial depth as the dentition status changed from completely dentulous to partially dentulous and from partially dentulous to completely edentulous state. Conclusions: The antegonial angle decreases with the advancing age and thereby increases the antegonial depth. Similar trends are seen when teeth are lost. Furthermore there is an inherent asymmetry in the antegonial region in right and left side

Recent Advances in Research on Down Syndrome

Down syndrome (DS) or trisomy 21 is one of the most important genetic causes of mental retardation. Sincere and significant attempts have been made towards understanding the congenital diseases that affect DS patients. Better understanding of gene networks associated with such malformations will help to predict the complex genetic trait behind congenital disease in DS and will also provide the basis for tailored gene therapies that could begin to heal or prevent such malformation without the need to resort to invasive surgery. Further, susceptible mutation screening in women will also be helpful for both prenatal diagnosis of DS birth and assessing the risk of predisposition to Alzheimer’s disease and congenital heart disease. Stress condition and neurodegeneration are two important markers in Down syndrome patients and mtDNA variation can also be used as an important biomarker. It has been suggested that nutraceuticals which reduce reactive oxygen species (ROS) level may be used to treat trisomy 21 condition. As mitochondria play a crucial role in the regulation of free radicals, only a detail analysis will reveal the origin of phenotypic characteristics among trisomy 21 DS patients. On the other hand, several mechanisms are responsible for neurodegeneration as well as altered cognition. It includes impaired neurogenesis leading to hypocellularity in the cortex, hippocampus and cerebellum, altered dendritic morphology, altered synapses, increased inhibition and neurodegeneration. The new knowledge of the pathogenic mechanisms in DS individuals has been acquired from mouse model. These studies provide the basis for developing new drugs for clinical trials in DS individuals and to sustain the hope that some of these drugs will be useful in treating intellectual disability in DS individuals

A Fully Biodegradable Ferroelectric Skin Sensor from Edible Porcine Skin Gelatine

High-performance biodegradable electronic devices are being investigated to address the global electronic waste problem. In this work, a fully biodegradable ferroelectric nanogenerator-driven skin sensor with ultrasensitive bimodal sensing capability based on edible porcine skin gelatine is demonstrated. The microstructure and molecular engineering of gelatine induces polarization confinement that gives rise the ferroelectric properties, resulting in a piezoelectric coefficient (d(33)) of approximate to 24 pC N-1 and pyroelectric coefficient of approximate to 13 mu C m(-2)K(-1), which are 6 and 11.8 times higher, respectively, than those of the conventional planar gelatine. The ferroelectric gelatine skin sensor has exceptionally high pressure sensitivity (approximate to 41 mV Pa-1) and the lowest detection limit of pressure (approximate to 0.005 Pa) and temperature (approximate to 0.04 K) ever reported for ferroelectric sensors. In proof-of-concept tests, this device is able to sense the spatially resolved pressure, temperature, and surface texture of an unknown object, demonstrating potential for robotic skins and wearable electronics with zero waste footprint

Classical oscillator with position-dependent mass in a complex domain

We study complexified Harmonic Oscillator with a position-dependent mass, termed as Complex Exotic Oscillator (CEO). The complexification induces a gauge invariance [19,11]. The role of PT -symmetry is discussed from the perspective of classical trajectories of CEO for real energy. Some trajectories of CEO are similar to those for the particle in a quartic potential in the complex domain [10, 32].Comment: 20 pages, 4 figures, title is changed, some new features have been discussed, to appear in Phys. Lett.

Moisture self-regulating ionic skins with ultra-long ambient stability for self-healing energy and sensing systems

Dehydration has been a key limiting factor for the operation of conductive hydrogels in practical application. Here, we report self-healable ionic skins that can self-regulate their internal moisture level by capturing extenral moistures via hygroscopic ion-coordinated polymer backbones through antipolyelectrolyte effect. Results show the ionic skin can maintain its mechanical and electrical functions over 16 months in the ambient environment with high stretchability (fracture stretch ∼2216 %) and conductivity (23.5 mS/cm). The moisture self-regulating capability is further demonstrated by repeated exposures to harsh environments such as 200°C heating, freezing, and vacuum drying with recovered conductivity and stretchability. Their reversible ionic and hydrogen bonds also enable self-healing feature as a sample with the fully cut-through damage can restore its conductivity after 24 h at 40 % relative humidity. Utilizing the ionic skin as a building block, self-healing flexible piezoelecret sensors have been constructed to monitor physiological signals. Together with a facile transfer-printing process, a self-powered sensing system with a self-healable supercapacitor and humidity sensor has been successfully demonstrated. These results illustrate broad-ranging possibilities for the ionic skins in applications such as energy storage, wearable sensors, and human-machine interfaces

Patent foramen ovale and atrial septal aneurysm in cryptogenic stroke

Up to 40% of acute ischaemic strokes in young adults are cryptogenic in nature, that is, no cause is determined. In more than half of these patients, patent foramen ovale (PFO) is seen along with an increased incidence of atrial septal aneurysm. The commonest method of investigation is echocardiography (preferably transoesophageal echocardiography). On the basis of available evidence, low risk patients are treated with antiplatelet agents and high risk patients with warfarin. There are inconclusive data on the efficacy of PFO closure to prevent stroke recurrence. However, if there is recurrent stroke or intolerance to medical therapy, percutaneous closure is carried out