Migrant’s the faceless & nameless economic driver amid Covid19.

India is least urbanized among top ten economies of the world. Recent years have seen a spurt in development in various sectors, and a transition of work force out from agriculture to other sectors; this coupled with jobless growth has made a huge flow of unskilled labours from various states. The so called Migrants, the faceless nameless people who are the real driver’s of our economy. They move from their states to other places in search of a livelihood, to sustain and survive, and contribute to our economy, in a subtle way we never actually thought off. There are many reasons for this, regional disparities, employment opportunities, are most prominent. Never the less their invisible hands are more needed than ever now, as we unlock and head towards economic activity, but maybe we have failed the migrant labours as a society. India’s informal workforce is made up of 80% migrant workers, and yet we haven’t given them the credibility they deserve. May be it’s time now, to acknowledge who they are, and what they are, else we risk losing the major workforce of our country, and face unprecedented economic consequences

Gandhian philosophy of health and hygeine in an era of pandemic

Challenges faced by the world today aren’t limited to a single sphere. Multiple avenues pose threats like never before; global warming with melting of arctic ice, raging fires in Amazon and Australia, humanitarian crisis of refugees, civil war in Libya and other parts of the world pose threats to the very Human existence. The very ecology is threatened on multiple frontiers due to these challenges. None the less, associated with this Health crisis of humongous proportions is causing catastrophe in various ways.  As the world advances and countries strive to keep pace with development, the cut throat competition has worsened the health crisis more than ever. Imbalances brought by humans are no longer sustained by Mother Nature. As the environment changes rapidly Nature is unleashing its fury on us, and what could be truer in today’s world gripped by a Pandemic that’s unleashing its wrath. Looking back, we will see Gandhiji’s simplicity in laying down models for health and hygiene are more realistic and true than ever. As we move forward in post pandemic era, Gandhiji’s simple measures almost a century old, holds more value than ever befor

MIGRANT’S THE FACELESS & NAMELESS ECONOMIC DRIVER AMID COVID19

India is least urbanized among top ten economies of the world. Recent years have seen a spurt in development in various sectors, and a transition of work force out from agriculture to other sectors; this coupled with jobless growth has made a huge flow of unskilled labours from various states. The so called Migrants, the faceless nameless people who are the real driver’s of our economy. They move from their states to other places in search of a livelihood, to sustain and survive, and contribute to our economy, in a subtle way we never actually thought off. There are many reasons for this, regional disparities, employment opportunities, are most prominent. Never the less their invisible hands are more needed than ever now, as we unlock and head towards economic activity, but maybe we have failed the migrant labours as a society. India’s informal workforce is made up of 80% migrant workers, and yet we haven’t given them the credibility they deserve. May be it’s time now, to acknowledge who they are, and what they are, else we risk losing the major workforce of our country, and face unprecedented economic consequences

Migrant’s the faceless & nameless economic driver amid Covid19.

India is least urbanized among top ten economies of the world. Recent years have seen a spurt in development in various sectors, and a transition of work force out from agriculture to other sectors; this coupled with jobless growth has made a huge flow of unskilled labours from various states. The so called Migrants, the faceless nameless people who are the real driver’s of our economy. They move from their states to other places in search of a livelihood, to sustain and survive, and contribute to our economy, in a subtle way we never actually thought off. There are many reasons for this, regional disparities, employment opportunities, are most prominent. Never the less their invisible hands are more needed than ever now, as we unlock and head towards economic activity, but maybe we have failed the migrant labours as a society. India’s informal workforce is made up of 80% migrant workers, and yet we haven’t given them the credibility they deserve. May be it’s time now, to acknowledge who they are, and what they are, else we risk losing the major workforce of our country, and face unprecedented economic consequences

Synthetic studies towards complex diterpenoids. Part 13. Stereo-specific synthesis of intermediates to the diterpene alkaloids and the C<SUB>20</SUB>-gibberellins by a novel rearrangement of angularly fused cyclo-butanones

A new stereospecific rearrangement of the saturated cyclobutanones (10a and b) and (11a and b) to the respective bridged cyclopentanones (2a and b) and (5a and b) using triethyloxonium tetrafluoroborate is described. Rearrangement studies of the specific labelled ketone [2H2]-(10a) indicate that the process is intramolecular. Sulphuric acid-catalysed rearrangement of (10a) produces the unsaturated methyl ketone (13). Transformation of the tetracyclic ketones (5a and b) to some angularly functionalised hydrofluorene synthons (14a and b) to the C20-gibberellins has been achieved

A novel rearrangement of angularly fused cyclobutanone. Stereospecific syntheses of intermediates to the diterpene alkaloids and the C20 gibberellins

This article does not have an abstract

Acid-catalysed intramolecular C-alkylation in βγ-unsaturated diazomethyl ketones. A new synthetic route to angularly fused cyclobutanones, bridged cyclopentanones, and γ-lactones

Acid-induced decomposition of rigid polycyclic βγ-unsaturated diazomethyl ketones (2a and b) and (4a and b) is shown to give, in excellent yields, the respective angularly fused unsaturated cyclobutanones (5a and b) and (6a and b) and/or the rearranged bridged hydroxycyclopentanones (7a) and (9a) depending upon the reagents, reaction conditions, and the nature of the substrates. Under certain conditions (5a) and (7a) undergo rearrangement to 3a-methyl-1,2,3,3a,6,7-hexahydropentaleno[1,6a-a]naphthalen-4-one (12a). The unsaturated cyclobutanones undergo stereoselective catalytic hydrogenation to the respective trans-angularly substituted hydrophenanthrene and hydrofluorene cyclobutanones (13a and b) and (14a and b) which on facile Bayer-Villiger oxidation produce the γ-lactones (18a and b) and (19a and b). The unsaturated cyclobutanones (5a and b) also afford the respective γ-lactones (20a and b) on oxidation with alkaline hydrogen peroxide

Self‐assembly and Neurotoxicity of Amyloid‐beta (21‐40) Peptide fragment: The regulatory Role of GxxxG Motifs

The three GxxxG repeating motifs from the C‐terminal region of β‐amyloid (Aβ) peptide play a significant role in regulating the aggregation kinetics of the peptide. Mutation of these glycine residues to leucine greatly accelerates the fibrillation process but generates a varied toxicity profile. Using an array of biophysical techniques, we demonstrated the uniqueness of the composite glycine residues in these structural repeats. We used solvent relaxation NMR spectroscopy to investigate the role played by the surrounding water molecules in determining the corresponding aggregation pathway. Notably, the conformational changes induced by Gly33 and Gly37 mutations result in significantly decreased toxicity in a neuronal cell line. Our results indicate that G33xxxG37 is the primary motif responsible for Aβ neurotoxicity, hence providing a direct structure–function correlation. Targeting this motif, therefore, can be a promising strategy to prevent neuronal cell death associated with Alzheimer's and other related diseases, such as type II diabetes and Parkinson's

Self‐assembly and Neurotoxicity of Amyloid‐beta (21‐40) Peptide fragment: The regulatory Role of GxxxG Motifs

The three GxxxG repeating motifs from the C‐terminal region of β‐amyloid (Aβ) peptide play a significant role in regulating the aggregation kinetics of the peptide. Mutation of these glycine residues to leucine greatly accelerates the fibrillation process but generates a varied toxicity profile. Using an array of biophysical techniques, we demonstrated the uniqueness of the composite glycine residues in these structural repeats. We used solvent relaxation NMR spectroscopy to investigate the role played by the surrounding water molecules in determining the corresponding aggregation pathway. Notably, the conformational changes induced by Gly33 and Gly37 mutations result in significantly decreased toxicity in a neuronal cell line. Our results indicate that G33xxxG37 is the primary motif responsible for Aβ neurotoxicity, hence providing a direct structure–function correlation. Targeting this motif, therefore, can be a promising strategy to prevent neuronal cell death associated with Alzheimer's and other related diseases, such as type II diabetes and Parkinson's