The potassium channel blocker, dalfampridine diminishes ouabain-induced arrhythmia in isolated rat atria

The aim of the present experiment was to investigate the possible antiarrhythmic effects of dalfampridine in ouabain-induced arrhythmia in rats. Twenty-four male rats including the control and dalfampridine-incubated (100 µM to 10�mM) ouabain-stimulated (40 µM) groups were used. After induction of anesthesia, the atria were isolated and the time of onset of arrhythmia and asystole were recorded. The contractile force of atria was also measured. Dalfampridine at concentration of 1�mM significantly postponed the onset of arrhythmia and asystole compared to control group (p���.05). Ouabain significantly increased the atrial beating rate in control group (p���.05), while pretreatment of isolated atria with dalfampridine reversed this effect. Incubation of isolated atria with ouabain did not alter the contractile force in both control- and dalfampridine-treated groups (p�>�.05). It is concluded that dalfampridine might possess antiarrhythmic properties in reducing the atrial arrhythmias. © 2018 Informa UK Limited, trading as Taylor & Francis Grou

The potassium channel blocker, dalfampridine diminishes ouabain-induced arrhythmia in isolated rat atria

The aim of the present experiment was to investigate the possible antiarrhythmic effects of dalfampridine in ouabain-induced arrhythmia in rats. Twenty-four male rats including the control and dalfampridine-incubated (100 µM to 10�mM) ouabain-stimulated (40 µM) groups were used. After induction of anesthesia, the atria were isolated and the time of onset of arrhythmia and asystole were recorded. The contractile force of atria was also measured. Dalfampridine at concentration of 1�mM significantly postponed the onset of arrhythmia and asystole compared to control group (p���.05). Ouabain significantly increased the atrial beating rate in control group (p���.05), while pretreatment of isolated atria with dalfampridine reversed this effect. Incubation of isolated atria with ouabain did not alter the contractile force in both control- and dalfampridine-treated groups (p�>�.05). It is concluded that dalfampridine might possess antiarrhythmic properties in reducing the atrial arrhythmias. © 2018 Informa UK Limited, trading as Taylor & Francis Grou

The potassium channel blocker, dalfampridine diminishes ouabain-induced arrhythmia in isolated rat atria

The aim of the present experiment was to investigate the possible antiarrhythmic effects of dalfampridine in ouabain-induced arrhythmia in rats. Twenty-four male rats including the control and dalfampridine-incubated (100 µM to 10 mM) ouabain-stimulated (40 µM) groups were used. After induction of anesthesia, the atria were isolated and the time of onset of arrhythmia and asystole were recorded. The contractile force of atria was also measured. Dalfampridine at concentration of 1 mM significantly postponed the onset of arrhythmia and asystole compared to control group (p �.05). Ouabain significantly increased the atrial beating rate in control group (p �.05), while pretreatment of isolated atria with dalfampridine reversed this effect. Incubation of isolated atria with ouabain did not alter the contractile force in both control- and dalfampridine-treated groups (p >.05). It is concluded that dalfampridine might possess antiarrhythmic properties in reducing the atrial arrhythmias. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group

Silver Cubes

An n × n matrix A is said to be silver if, for i = 1,2,...,n, each symbol in {1,2,...,2n − 1} appears either in the ith row or the ith column of A. The 38th International Mathematical Olympiad asked whether a silver matrix exists with n = 1997. More generally, a silver cube is a triple (K d n,I,c) where I is a maximum independent set in a Cartesian power of the complete graph Kn, and c: V (K d n) → {1,2,...,d(n − 1) + 1} is a vertex colouring where, for v ∈ I, the closed neighbourhood N[v] sees every colour. Silver cubes are related to codes, dominating sets, and those with n a prime power are also related to finite geometry. We present here algebraic constructions, small examples, and a product construction. The nonexistence of silver cubes for d = 2 and some values of n, is proved using bounds from coding theory