21 research outputs found
Effect of Onopordon acanthium L. as add on antihypertensive therapy in patients with primary hypertension taking Losartan: A pilot study
Get PDFPurpose: Onopordon acanthium L. is known for its medicinal properties. Our recent study showed that its seed extract is a novel natura angiotensin-converting-enzyme inhibitor (ACEI). This study was carried out to investigate its possible antihypertensive effects in patients receiving losartan. Methods: This uncontrolled clinical trial was carried out among 20 patients (30-60y) with uncontrolled hypertension despite receiving 50 mg losartan (stage I & II) in two hospitals in Iran. After completing informed consent, patients were treated by 2 capsules each 1g of Onopordon acanthium seed extract (OSE) as add-on therapy, two times per day. Results: 18 patients completed the study (50.94 ±8.37y). Mean systolic blood pressure (SBP) at the baseline was 151.9 ± 13.74mmHg and at the end of the study, it was 134.6 ± 18.25 mmHg and mean diastolic blood pressure (DBP) was 97.41 ± 10.36 at the baseline and was 85.71 ± 7.481 after 8 weeks. OSE significantly reduced SBP and DBP at the end of 8 weeks (P=0.003, 95% CI: -19.7, -15.1; P=0.0006, 95% CI: -10.23, -13.15; respectively). No evidence of hepatic or renal toxicity was detected. Conclusion: Based on the results of this study OSE has antihypertensive property with no significant adverse effects. However, because of the low number of samples, this medication may be not safely administered. The results of this study could be the basis for further studies with larger sample size. IRCT registration number: IRCT2013020712391N. © 2018 The Authors
Effect of Onopordon acanthium L. as add on antihypertensive therapy in patients with primary hypertension taking Losartan: A pilot study
Get PDFPurpose: Onopordon acanthium L. is known for its medicinal properties. Our recent study showed that its seed extract is a novel natura angiotensin-converting-enzyme inhibitor (ACEI). This study was carried out to investigate its possible antihypertensive effects in patients receiving losartan. Methods: This uncontrolled clinical trial was carried out among 20 patients (30-60y) with uncontrolled hypertension despite receiving 50 mg losartan (stage I & II) in two hospitals in Iran. After completing informed consent, patients were treated by 2 capsules each 1g of Onopordon acanthium seed extract (OSE) as add-on therapy, two times per day. Results: 18 patients completed the study (50.94 ±8.37y). Mean systolic blood pressure (SBP) at the baseline was 151.9 ± 13.74mmHg and at the end of the study, it was 134.6 ± 18.25 mmHg and mean diastolic blood pressure (DBP) was 97.41 ± 10.36 at the baseline and was 85.71 ± 7.481 after 8 weeks. OSE significantly reduced SBP and DBP at the end of 8 weeks (P=0.003, 95% CI: -19.7, -15.1; P=0.0006, 95% CI: -10.23, -13.15; respectively). No evidence of hepatic or renal toxicity was detected. Conclusion: Based on the results of this study OSE has antihypertensive property with no significant adverse effects. However, because of the low number of samples, this medication may be not safely administered. The results of this study could be the basis for further studies with larger sample size. IRCT registration number: IRCT2013020712391N. © 2018 The Authors
Assessment of cardiac risk factors in medical students of tehran university
Get PDFPrevention of coronary heart disease, mainly by reducing the levels of known risk factors in the population, remains a priority in public health. This cross-sectional study on randomly selected medical students during their internship was conducted from July 2001 to April 2002 in order to determine the prevalence of major coronary artery disease (CAD) risk factors. This survey was done by filling the questionnaire, measuring physical parameters, and taking a fasting blood sample. Two hundred and sixty four medical students were evaluated in this study (48 female, 216 male) with the mean age of 26.5 ± 2.8 years. The main risk factors in descending order of frequency were physical inactivity (43.5%), low high-density lipoprotein cholesterol (26.2%), family history of premature CAD (15.9%), smoking (10.3%), abdominal obesity (10.2%), high triglyceride level (5.3%), high blood pressure (3.4%), and high low-density lipoprotein cholesterol (1.5%). Also, 25% of married females were using oral contraceptives regularly. The number of risk factors per person was 2.2 on average (1.1 in females and 2.5 in males). Prevalence of CAD ri sk factors in this medical students’ population was unacceptably high. Additional studies should be done to gather more information and determine the need for preventive, educational or curative interventions
Establishment of three new genera in the family Geminiviridae: Becurtovirus, Eragrovirus and Turncurtovirus
Full text linkENDOCARDITIS WITH AN UNCOMMON GERM
No full textEnterococci are normal inhabitants of gastrointestinal tract, being responsible for 5 to 18% of infective endocarditis and the incidence appears to be increasing. Eleven patients with enterococcal endocarditis were studied. In a case series group, 10 men (average 57 years) and one woman (37 years) were studied. Two patients had rheumatic heart disease, 5 patients arteriosclerotic disease and one patient chronic renal failure on hemodialysis. Ten patients were treated with ampicillin and gentamycin. Valve replacement was performed in 3 patients with aortic valve endocarditis, one on 8th day and two at the end of the treatment. Overall clinical cure was achieved in 9 patients. Two relapses occurred and 2 patients died as a result of refractory congestive heart failure and cerebral emboli. All of the enterococcal endocarditis cases were community acquired. In conclusion, infective endocarditis in patients with preexistent valvular heart disease, community acquisition and non specific symptoms with bacteriuria should be considered as enterococcal endocarditis
INVESTIGATING THE EFFECT OF FIBER ON COMPRESSIVE AND SPLITTING TENSILE BEHAVIOR OF CONCRETE VIA EXPERIMENTAL TESTS, DIGITAL IMAGE ORRELATIONS
No full textThe improvement of compressive and tensile strength of concrete has a great
importance in the construction industry. In this study, cubic samples constructed in a dimension of 150\times150\times150 mm containing different amounts of macro-synthetic (0.1 and 0.15 vol.\%) and polymeric fibers (0.2, 0.3, and 0.35
vol.\%) by means of seven mix designs. Compressive and splitting tests were
performed using a universal testing machine. For each specimen, stress-strain
and load-displacement behaviors, absorbing energy, ductility and crack patterns
were investigated. In order to analyze the strain variations on the surface of
the specimens digital image correlation (DIC) was applied. Moreover, finite
element method (FEM) was conducted to evaluate the experimental results. The
results of this study show that the presence of fibers in concrete has a
significant effect on reducing size and number of cracks, and increases
displacement compared to conventional concrete. In addition, displacement at
the failure moment in tension and pressure for fiber contained concrete was
more than the control specimen. According to the observations, addition of the
fibers reduces compressive and tensile strength. However, it is so obvious from
the results that by choosing the optimal amount, this reduction would be
neglected in comparison with the positive effects of the fibers. Finally, the
results indicate an acceptable agreement between the FEM and DIC evaluations.
Therefore, considering the low cost and high speed of analysis with FEM and DIC
methods, it is possible to combine these two methods as a useful tool to determine the surface characteristics of such specimens
Poor physical activity in the elderly as assessed by a visual analogue scale is associated with dyslipidemia
No full textSpace shuttle SRM field joint: Review paper
No full textDue to Challenger space shuttle accident in 1986, significant research has been done concerning structural behavior of field joints in solid rocket boosters (SRB). The structural deformations between the clevis inner leg and the tang (male-to-female parts of joint), the sealing of the O-ring to prevent the hot gas in joints, has been neglected causing the failure of the vehicle. Redesigning the field joint in SRB engine by accurate analysis of dynamic and thermal loads and by design of insulator and good O-ring, the leakiness of combustion hot gases was eliminated. Some parts of field joint such as capture feature (CF) and its third O-ring, J-leg insulator and shim were added to redesigned field joint. Also, some adjustments in sealing system and pins were done to promote the efficiency of the field joint. Due to different experimental analysis on assembled field joints with default imperfections, redesigned joints operated well. These redesigned field joints are commonly used in aerospace and mechanical structures. This paper investigates the original and the redesigned field joints with additional explanations of different parts of the redesigned joints. http://dx.doi.org/10.5937/metmateng1403155
Evaluation of Survival Rate and Tissue Health Indexes around the Dio® SM Dental Implants Placed in the Patients of a Dental Office in Isfahan from 2005 until 2010
No full textIntroduction: Dental implants are the choice of treatment for missing teeth. Despite the very good results, implant treatment is also associated with some failures and complications. The aim of this study was evaluation of survival rate and tissue health indexes around the Dio® SM dental implants placed in patients of dental school and a private office in Isfahan from 2005 until 2010.
Methods: In this cross sectional study, 94 Dio® SM dental implants in 72 patients via convenience sampling were selected. After that demographic information and Gingival index, Gingival Bleeding index around Dio SM implants, plaque index, pocket depth, Bone loss were fulfilled for patients. Data analyzed using t-test, Chi-square test, Wilcoxon and Pearson test with SPSS Ver. 20 statistical software, at α =0.05.
Results: Among 94 implants, 55.6 % in maxilla, 44.4% in the mandible, 53.19% single and 46.81% were multi-unit. Survival rate of total implants was 80.6% and 19.4% were failed because of different
causes. Among indices Gingival index(p=0/001), plaque index(p=0/020),pocket depth(p<0/001) were
significantly lower than theeth. Periodontal indices except bleeding index were significantly higher
in maxilla (p<0.05) but bone loss was not significant(p=0.071).
Conclusions: The results of this study showed that survival rate of Dio® SM implants is lower than acceptable rate but needs to more studies
Analysis investigation of composite lattice conical shell as satellite carrier adapter for aerospace applications
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