BLOOD LIPID DISORDER IN MEN WITH INCREASED WAIST CIRCUMFERENCE COMPARED TO MEN HAVING NORMAL WAIST CIRCUMFERENCE WITHIN THE SAME CATEGORY OF BMI

Background: No local studies have been performed yet to investigate the influence of central or abdominal obesity on serum lipids in men having increased Waist Circumference (WC) compared to men with normal Waist Circumference values within the same BMI (Body Mass Index) category. Objective:To examine whether the prevalence of dyslipidemia, (defined as Hypercholesterolemia (Total Cholesterol level ≥240 mg/dl), high LDL-C level (≥160 mg/dl), low HDL-C level (<35 mg/dl), or Hypertriglyceridemia (TG level ≥200 mg/dl)), is higher in men having high Waist Circumference compared to others with normal WC values within the same BMI category. Methods: The study was conducted between September 2013 and July 2014. Eighty-eight overweight men (BMI = 25-29.9) were grouped by WC as follows: 28 with high values (>102 cm) and 60 with normal values (≤ 102cm). Blood samples were drawn and assayed for total cholesterol, triglyceride, HDL-C, and LDL-C,at the department of Laboratory in the Faculty of Public Health, Lebanese University. All assays were performed by enzymatic colorimetric methods using Hitachi-704. Results: Overweight men with high WC values (according to cutoff points internationally adopted) were the most likely to have dyslipidemia with its subsequent increased health risk compared with those having normal WC values. Conclusion: we showed in this study that the prevalence of dyslipidemia in men with high WC values is greater compared to those with normal WC values within the same BMI category. This finding leads us to the importance of the incorporated evaluation of WC in addition to the BMI in clinical practice

BLOOD LIPID DISORDER IN MEN WITH INCREASED WAIST CIRCUMFERENCE COMPARED TO MEN HAVING NORMAL WAIST CIRCUMFERENCE WITHIN THE SAME CATEGORY OF BMI

Background: No local studies have been performed yet to investigate the influence of central or abdominal obesity on serum lipids in men having increased Waist Circumference (WC) compared to men with normal Waist Circumference values within the same BMI (Body Mass Index) category. Objective:To examine whether the prevalence of dyslipidemia, (defined as Hypercholesterolemia (Total Cholesterol level ≥240 mg/dl), high LDL-C level (≥160 mg/dl), low HDL-C level (<35 mg/dl), or Hypertriglyceridemia (TG level ≥200 mg/dl)), is higher in men having high Waist Circumference compared to others with normal WC values within the same BMI category. Methods: The study was conducted between September 2013 and July 2014. Eighty-eight overweight men (BMI = 25-29.9) were grouped by WC as follows: 28 with high values (>102 cm) and 60 with normal values (≤ 102cm). Blood samples were drawn and assayed for total cholesterol, triglyceride, HDL-C, and LDL-C,at the department of Laboratory in the Faculty of Public Health, Lebanese University. All assays were performed by enzymatic colorimetric methods using Hitachi-704. Results: Overweight men with high WC values (according to cutoff points internationally adopted) were the most likely to have dyslipidemia with its subsequent increased health risk compared with those having normal WC values. Conclusion: we showed in this study that the prevalence of dyslipidemia in men with high WC values is greater compared to those with normal WC values within the same BMI category. This finding leads us to the importance of the incorporated evaluation of WC in addition to the BMI in clinical practice

EVALUATION OF SECONDARY OSTEOPOROSIS WITH BONE MINERAL DENSITOMETRY AND BONE TURNOVER MARKERS

Osteoporosis is as a very complex multi-factorial pathogenesis; thereby any doctor facing a case of osteoporosis must be very careful. Diagnostic procedures are complex and include careful monitoring of the history of patient, physical examination and some laboratory analysis. In this study, 201 patients aged between 50 and 95 years were selected from 4872 patients consulting orthopedic clinics. This group (201 patients: 168 women, 33 men) showed evidence of osteoporosis: BMD DXA with reduced bone mineral density,T-score: greater than -2.5 SD, or X-ray signs of non traumatic fractures. Patients also underwent biochemical and instrumental investigations for an assessment of bone metabolism. Age, gender, medical history as well as tests of rheumatic metabolism, calcium-phosphorus and some indices of bone turnover were determined for each patient. Interestingly, our data showed that 104 patients had a vertebral fracture without trauma, 22 hypothyroid patients were undergoing treatment with levothyroxine, 3 patients were suffering from autoimmune thyroiditis, 3 patients were suffering from secondary hyperparathyroidism with vitamin D deficiency, 2 patients were suffering from adenoma with primary hyperparathyroidism, 20 were diabetic patients, 7 patients had monoclonal gammopathy, 7 women had hystero- ovario salpingectomy, 7 patients were HCV positive, 4 patients with rheumatoid arthritis had been treated with corticosteroids, 2 patients were suffering from multiple myeloma, and 1 patient had Crohn's disease. There was also 1 suspected case of ulcerative colitis, 5 patients were suffering from celiac disease and other cases described in the paper. As a result of this diverse association, the approach to treating osteoporotic patients should be then accurate and multidisciplinary. It is then important to perform laboratory tests and investigations for correct diagnosis and adequate treatment

EVALUATION OF SECONDARY OSTEOPOROSIS WITH BONE MINERAL DENSITOMETRY AND BONE TURNOVER MARKERS

Osteoporosis is as a very complex multi-factorial pathogenesis; thereby any doctor facing a case of osteoporosis must be very careful. Diagnostic procedures are complex and include careful monitoring of the history of patient, physical examination and some laboratory analysis. In this study, 201 patients aged between 50 and 95 years were selected from 4872 patients consulting orthopedic clinics. This group (201 patients: 168 women, 33 men) showed evidence of osteoporosis: BMD DXA with reduced bone mineral density,T-score: greater than -2.5 SD, or X-ray signs of non traumatic fractures. Patients also underwent biochemical and instrumental investigations for an assessment of bone metabolism. Age, gender, medical history as well as tests of rheumatic metabolism, calcium-phosphorus and some indices of bone turnover were determined for each patient. Interestingly, our data showed that 104 patients had a vertebral fracture without trauma, 22 hypothyroid patients were undergoing treatment with levothyroxine, 3 patients were suffering from autoimmune thyroiditis, 3 patients were suffering from secondary hyperparathyroidism with vitamin D deficiency, 2 patients were suffering from adenoma with primary hyperparathyroidism, 20 were diabetic patients, 7 patients had monoclonal gammopathy, 7 women had hystero- ovario salpingectomy, 7 patients were HCV positive, 4 patients with rheumatoid arthritis had been treated with corticosteroids, 2 patients were suffering from multiple myeloma, and 1 patient had Crohn's disease. There was also 1 suspected case of ulcerative colitis, 5 patients were suffering from celiac disease and other cases described in the paper. As a result of this diverse association, the approach to treating osteoporotic patients should be then accurate and multidisciplinary. It is then important to perform laboratory tests and investigations for correct diagnosis and adequate treatment

THE CORRELATION BETWEEN THE METABOLIC DISORDERS IN OBESE MEN AND THE BODY MASS INDEX (BMI)

Background: The influence of body weight on serum lipids and uric acid is often overlooked in clinical practice. Objective: To study the magnitude of metabolic disorders (dyslipidemia and hyper-urecaemia) in asymptomatic obese men and its relation to body mass index (BMI). Methods: The study was conducted between September 2013 and July of 2014 at the medical analyses center in the Faculty of Public Health, Lebanese University. The weight, height, BMI, waist circumference (WC) uric acid, and lipid profile of 148 obese males, apparently healthy, compared with 80 males in a control group (BMI < 25 kg / m²), were investigated. Subjects were grouped by BMI and WC in accordance with the National Institutes of Health cutoff points. Within the normal-weight (18.5-24.9), overweight (25.0-29.9), and obese (≥ 30.0) BMI categories, we distributed the results of all the blood tests and we computed the prevalence of dyslipidemia and hyperurecaemia. Results: The present work revealed that with increasing body weight, the mean total cholesterol, LDL-C, triglycerides(TG), and uric acid increased; while the mean HDL-C decreased. These changes were as follows: the means difference between the first and second group and between the second and the third group were 29 and 31 mg/dl respectively regarding total cholesterol; for TG, these were 47.5 and 53.4 mg/dl; for LDL-C, these were 12 and 29 mg/dl; for HDL-C, these were 3.6 and 3.5 mg/dl; for uric acid, these were 0.3 mg/dl as a common difference, P=0.0245). Conclusion: Excess body weight is associated with deleterious changes in the lipoprotein profile and uric acid