Time series forecasting of styrene price using a hybrid ARIMA and neural network model

Every player in the market has a greater need to know about the smallest change in the market. Therefore, the ability to see what is ahead is a valuable advantage. The purpose of this research is to make an attempt to understand the behavioral patterns and try to find a new hybrid forecasting approach based on ARIMA-ANN for estimating styrene price. The time series analysis and forecasting is an essential tool which could be widely useful for finding the significant characteristics for making future decisions. In this study ARIMA, ANN and Hybrid ARIMA-ANN models were applied to evaluate the previous behavior of a time series data, in order to make interpretations about its future behavior for styrene price. Experimental results with real data sets show that the combined model can be most suitable to improve forecasting accurateness rather than traditional time series forecasting methodologies. As a subset of the literature, the small number of studies have been done to realize the new forecasting methods for forecasting styrene price

The Influence of Marketing Factors on the Marketing Strategic Planning in SNOWA Corporation

The purpose of this research is to evaluate the influence of marketing factors of SNOWA Corporation on its marketing strategic planning. The present study is an applied research using a descriptive-analytic method. The statistical sample of this research includes 300 personnel of SNOWA Corporation. Data were collected applying a standard questionnaire on a five-point Likert scale. CVR and CVI indices were used to evaluate the content validity of the questionnaire, and a Cronbach's Alpha Test was applied to assess its reliability. SPSS Software (factor analysis) and Amos Software (structural equation modelling) were applied to analyse the collected data. The study will help managers accomplish market opportunities efficiently while formulating corporation strategies. Findings further reveal that consideration of marketing factors can give managers valuable information that, if applied correctly, can effectively guarantee corporation's success

The close relationship between the Golgi trafficking machinery and protein glycosylation

La glicosilazione è la più comune modifica post-traduzionale delle proteine; media la loro corretta piegatura e stabilità, nonché il loro trasporto attraverso il trasporto secretorio. I cambiamenti nei glicani legati all'N e all'O sono stati associati a molteplici condizioni patologiche tra cui disturbi congeniti della glicosilazione, malattie infiammatorie e cancro. La glicosilazione della glicoproteina al Golgi coinvolge l'azione coordinata di centinaia di glicosiltransferasi e glicosidasi, che vengono mantenute nella posizione corretta attraverso il traffico di vescicole retrograde tra le cisterne di Golgi. In questa recensione, descriviamo il macchinario molecolare coinvolto nel traffico di vescicole e nel tethering presso l'apparato di Golgi e gli effetti delle mutazioni nel contesto della biosintesi dei glicani e delle malattie umane.Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in N- and O-linked glycans have been associated with multiple pathological conditions including congenital disorders of glycosylation, inflammatory diseases and cancer. Glycoprotein glycosylation at the Golgi involves the coordinated action of hundreds of glycosyltransferases and glycosidases, which are maintained at the correct location through retrograde vesicle trafficking between Golgi cisternae. In this review, we describe the molecular machinery involved in vesicle trafficking and tethering at the Golgi apparatus and the effects of mutations in the context of glycan biosynthesis and human diseases

Oncogenic roles of GOLPH3 in the physiopathology of cancer

Golgi phosphoprotein 3 (GOLPH3), un effettore del fosfatidilinositolo 4-fosfato [PI (4) P] al Golgi, è necessaria per il mantenimento della struttura del nastro del Golgi, il traffico di vescicole e la glicosilazione del Golgi. GOLPH3 è stato convalidato come oncoproteina combinando la genomica integrativa con l'analisi clinopatologiche e funzionali. È spesso amplificato in diversi tipi di tumori solidi tra cui melanoma, cancro ai polmoni, cancro al seno, glioma e cancro del colon-retto. La sovraespressione di GOLPH3 è correlata a una prognosi infausta in più tipi di tumore, compreso il 52% dei tumori al seno e dal 41% al 53% del glioblastoma. I ruoli di GOLPH3 nella tumorigenesi possono essere correlati a diverse attività cellulari, tra cui: (i) regolazione del traffico dal Golgi alla membrana plasmatica e contributo a fenotipi secretori maligni; (ii) controllare l'internalizzazione e il riciclaggio di molecole di segnalazione chiave o aumentare la glicosilazione delle glicoproteine ​​rilevanti per il cancro; e (iii) influenzare la risposta al danno al DNA e il mantenimento della stabilità genomica. Qui riassumiamo le attuali conoscenze sui percorsi oncogeni che coinvolgono GOLPH3 nel cancro umano, l'influenza di GOLPH3 sul metabolismo del tumore e sullo stroma circostante e il suo possibile ruolo nella formazione di metastasi tumorali.Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified in several solid tumor types including melanoma, lung cancer, breast cancer, glioma, and colorectal cancer. Overexpression of GOLPH3 correlates with poor prognosis in multiple tumor types including 52% of breast cancers and 41% to 53% of glioblastoma. Roles of GOLPH3 in tumorigenesis may correlate with several cellular activities including: (i) regulating Golgi-to-plasma membrane trafficking and contributing to malignant secretory phenotypes; (ii) controlling the internalization and recycling of key signaling molecules or increasing the glycosylation of cancer relevant glycoproteins; and (iii) influencing the DNA damage response and maintenance of genomic stability. Here we summarize current knowledge on the oncogenic pathways involving GOLPH3 in human cancer, GOLPH3 influence on tumor metabolism and surrounding stroma, and its possible role in tumor metastasis formation

Model-based Building Retrofit: Experiences at Sharif University of Technology

This paper presents a model-based technique for building retrofit planning. The approach is based on the building energy model. An algorithm has been developed to calibrate building energy model based on hourly data. The calibrated model is used to select candidate retrofit actions and assess the energy saving potential associated with each candidate action. The proposed technique has been applied for retrofit planning in Department of Energy Engineering (DOEE) at the Sharif University of Technology in 2015. An smart reading system has been also developed to capture the hourly gas consumption for DOEE. Building energy model for DOEE has been developed in EnergyPlus and calibrated using the proposed algorithm. A set of retrofit action has been selected and implemented in DOEE based on the proposed technique. The results showed that the average cooling energy use in summers was reduced by 20% compared to the 6-year average summer energy use before retrofit. The results showed that only HVAC control has more than 8% impact on cooling energy use

A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila.

In animal cell cytokinesis interaction of non-muscle Myosin II (NMII) with F-actin provides the dominant force for pinching the mother cell into two daughters. Here we demonstrate that celibe (cbe) is a missense allele of zipper, which encodes the Drosophila Myosin heavy chain. cbe mutation impairs binding of Zipper protein to the regulatory light chain Spaghetti Squash (Sqh). In dividing spermatocytes from cbe males, Sqh fails to concentrate at the equatorial cortex, resulting in thin actomyosin rings that are unable to constrict. We show that cbe mutation impairs localization of the Phosphatidylinositol 4-phosphate [PI(4)P] binding protein Golgi phosphoprotein 3 (GOLPH3) and maintenance of centralspindlin at the cell equator of telophase cells. Our results further demonstrate that GOLPH3 protein associates with Sqh and directly binds the centralspindlin subunit Pavarotti. We propose that during cytokinesis the reciprocal dependence between Myosin and PI(4)P-GOLPH3 regulates centralspindlin stabilization at the invaginating plasma membrane and contractile ring assembly

GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila

The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human GOLPH3 correlates with poor prognosis in several cancer types and is associated with enhanced signaling downstream of mTOR (mechanistic target of rapamycin). However, the molecular link between GOLPH3 and mTOR remains elusive. Studies in Drosophila melanogaster have shown that Translationally controlled tumor protein (Tctp) and 14-3-3 proteins are required for organ growth by supporting the function of the small GTPase Ras homolog enriched in the brain (Rheb) during mTORC1 (mTOR complex 1) signaling. Here we demonstrate that Drosophila GOLPH3 (dGOLPH3) physically interacts with Tctp and 14-3-3ζ. RNAi-mediated knockdown of dGOLPH3 reduces wing and eye size and enhances the phenotypes of Tctp RNAi. This phenotype is partially rescued by overexpression of Tctp, 14-3-3ζ, or Rheb. We also show that the Golgi localization of Rheb in Drosophila cells depends on dGOLPH3. Consistent with dGOLPH3 involvement in Rheb-mediated mTORC1 activation, depletion of dGOLPH3 also reduces levels of phosphorylated ribosomal S6 kinase, a downstream target of mTORC1. Finally, the autophagy flux and the expression of autophagic transcription factors of the TFEB family, which anti correlates with mTOR signaling, are compromised upon reduction of dGOLPH3. Overall, our data provide the first in vivo demonstration that GOLPH3 regulates organ growth by directly associating with mTOR signaling proteins

Planning of multi-hub energy system by considering competition issue

Energy hub concept has been emerged as a suitable tool to analyze multi-carrier energy systems. Deregulation and increasing competition in the energy industry have provided a suitable platform for developing the multi-agent energy systems. Planning of energy hubs considering the competition between the hubs has not been sufficiently addressed, yet. A model has been proposed in this study for planning of a multi-hub energy system considering the competition between the hubs.  The hubs are interconnected via an electric transmission system. A linear model has been developed to determine the optimal planning/operation strategy for energy hubs in a multi-period planning horizon to meet the heat and electricity demand for the defined load zone. The problem has been formulated and solved using Karush–Kuhn–Tucker (KKT) conditions. The proposed model has been applied to 3-Hub and 5-Hub energy systems. The effect of renewable generation and storage system has also been evaluatedIt has also been observed that inclusion of renewable generation or storage technologies can reduce the conventional electricity generation capacity by 63 percent in HUB2

Identification of GOLPH3 Partners in <i>Drosophila</i> Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders.

Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein localized to the Golgi apparatus and the cytosol. GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate [PI(4)P] and regulates Golgi architecture and vesicle trafficking. GOLPH3 overexpression has been correlated with poor prognosis in several cancers, but the molecular mechanisms that link GOLPH3 to malignant transformation are poorly understood. We recently showed that PI(4)P-GOLPH3 couples membrane trafficking with contractile ring assembly during cytokinesis in dividing Drosophila spermatocytes. Here, we use affinity purification coupled with mass spectrometry (AP-MS) to identify the protein-protein interaction network (interactome) of Drosophila GOLPH3 in testes. Analysis of the GOLPH3 interactome revealed enrichment for proteins involved in vesicle-mediated trafficking, cell proliferation and cytoskeleton dynamics. In particular, we found that dGOLPH3 interacts with the Drosophila orthologs of Fragile X mental retardation protein and Ataxin-2, suggesting a potential role in the pathophysiology of disorders of the nervous system. Our findings suggest novel molecular targets associated with GOLPH3 that might be relevant for therapeutic intervention in cancers and other human diseases