Emotional Processing In Patients with Ischemic Heart Diseases

BACKGROUND: Cardiovascular disease is the most prevalent public health problem on a worldwide scale, and ischemic heart disease accounts for approximately one-half of these events in high-income countries. One of the most important risk factors for this disease is mental and psychological especially stressful experiences. AIM: This research was established to compare emotional processing, as a key factor in stress appraisal, between IHD patients and people with no cardiovascular disease. METHODS: Using simple sampling, fifty patients were selected from people who diagnosed as IHD in the hospital and referred for treatment after discharging care and treatment. Control group participants were selected as control group peoples, using neighbourhood controls selection. The Emotional Processing Scale was filled by all members of the two groups. RESULTS: There were significant differences between the two groups on the EPS-25 total scores, as well as on emotional processing dimensions of signs of unprocessed emotion, unregulated emotion; avoidance and impoverished. Also, there was no significant difference between the two groups in the dimension of Suppression. The final step of regression revealed a β of 10.15 and 1.05 for AVO and IEE subscales respectively. CONCLUSION: The result showed that patients with IHD are using more negative emotional processing styles

Construct and Psychometric Properties of a New Version Quality of Life Scale Based on Choice Theory

BACKGROUND: Choice theory, as a psychopathological model, postulated five basics, genetically and universally, needs. Accordingly, the rate of everybody happiness and quality of life is depended on the number of his needs fulfilling. Although some scales have been constructed to assess basic needs, they have proposed unity of needs for all human. AIM: The present study was designed to construct a new scale, considering individualisation needs for each person; quality of life scale based on choice theory (QOLSCT). METHODS: Using cluster sampling, six hundred (49% female and 51% male) postgraduate students were selected. One hundred fifty participants also filled SF-36 and GHQ, and 80 participants refilled QOLSCT with four weeks’ interval again. RESULTS: Cronbach’s alpha, split-half and test re-test (one month) reliability scores were 0.78, 0.75, and 0.92 successively. The correlation between items and total scores range from 0.36 to 0.72, all with P values ≥ 0.0001. Confirmatory factor analysis showed satisfactory values of goodness-of-fit indices, RMSEA, CFI, NFI and GFI were, 0.05, 0.99, 0.99 and 0.99 respectively. Convergent and divergent validity also showed significant correlations. CONCLUSION: The result of the present study showed that the new version of quality of life scale based on choice theory could be confirmed. The good level of reliability, fairly goodness of fit indexes, and very good convergent validity support this idea

Effects of Combined Intralesional 5-Fluorouracil and Topical Silicone in Prevention of Keloids: A Double Blind Randomized Clinical Trial Study

Keloids are aesthetically disfiguring and severely disabling. The optimal treatment remains undefined. This clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-Fluorouracil on the prevention of keloids. In this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. The control group were treated by perilesional surgical excision of keloids combined with topical silicone and the trial group were treated with adjuvant treatment of intralesional 5-Fluorouracil. All patients were examined and assessment was done by an independent observer. the data collected were analyzed by SPSS statistical software with using tables and χ square tests. 75% of the cases in the trial group were keloid free 21% have keloid partially improvement and 4% have keloid recurrence, compared to patients in the control group respectively: 43%, 35% and 22%, findings suggest that efficacy of 5-Fluorouracil combined with topical silicone used for the prevention of keloid is comparable to other modality. The lack of any serious side effects and the evidence of recurrence at one year of follow-up make this an effective tool for the prevention of keloids

A Bayesian analysis with informative prior on disease prevalence for predicting missing values due to verification bias

AIM: Verification bias is one of the major problems encountered in diagnostic accuracy studies. It occurs when a standard test performed on a non-representative subsample of subjects which have undergone the diagnostic test. In this study we extend a Bayesian model to correct this bias. METHODS: The study population is patients that have undergone at least two repeated failed IVF/ICSI (in vitro fertilization/intra cytoplasmic sperm injection) cycles. Patients were screened using ultrasonography and those with polyps were recommended for hysteroscopy. A Bayesian modeling was applied on mechanism of missing data using an informative prior on disease prevalence. The parameters of the model were estimated through Markov Chain Monte Carlo methods. RESULTS: A total of 238 patients were screened, 47 of which had polyps. Those with polyps were strongly recommended to undergo hysteroscopy, 47/47 decide to have a hysteroscopy and in 37/47 polyps confirmed. None of the 191 patients with no polyps detected in ultrasonography underwent a hysteroscopy. A model using Bayesian approach was applied with informative prior on polyp prevalence. False and true negatives were estimated in the Bayesian framework. The false negative was obtained 14 and 177 true negatives were obtained, so sensitivity and specificity was estimated easily after estimating the missing data. Sensitivity and specificity were equal to 74% and 94% respectively. CONCLUSION: Bayesian analyses with informative prior seem to be powerful tools in the simulation of experimental spac

Pomegranate Seed Oil Shows Inhibitory Effect on Invasion of Human Breast Cancer Cell Lines

Introduction: The pomegranate seeds are a good source of compounds such as conjugated linoleic acid and punicic acid that can have anticancer effects. Aim: To assess the potential inhibitory effects of Pomegranate Seed Oil (PSO) on human breast cancer cell lines metastasis. Materials and Methods: This research was an in vitro study on human breast cancer cell lines MCF-7 and MDA-MB-468. Pomegranate was collected from Fars Province of Iran and the seed oil was extracted. Cells were treated with different concentrations of the oil and their viability was determined using MTT assay. The morphology, colony formation, invasion, migration, wound healing and cell adhesion of cancer cell lines were evaluated. Half maximal inhibitory concentration (IC50) was obtained after 24, 48 and 72hrs. of treatment of cell lines. The statistical analysis of results were done by SPSS 19.0 software using One-way ANOVA followed by Post-hoc Tukey test and the level of significance was set at p<0.05. Results: The colony formation for MCF-7 and MDA-MB-468 cell lines were reduced compared to the control. At doses of 800 µg/mL and 1000 µg/mL for MCF-7 and MDA-MB-468, morphological changes have been observed. The MCF-7 cells migration was dropped in a dose equivalent to 1150 µg/mL and for MDA-MB-468 cells at a dose equivalent to 842 µg/ mL. In MDA-MB-468 cells, the cellular invasion was dropped in a dose equivalent to 842 µg/mL. Attachment assay showed that cell binding at a dose equivalent to IC50 for both cell lines dramatically was reduced. Wound healing test results indicated that PSO prevents MCF-7 and MDA-MB-468 cell lines migration toward the split. Conclusion: The results indicate that PSO may inhibit the migration and invasion of MDA-MB-468 cell line