Poly[[piperazine-1,4-dium [diaqua­tetra­kis­(μ-sulfanediyldiacetato)­dicerate(III)]] trihydrate]

The title compound, (C4H12N2)[Ce2(C4H4O4S)4(H2O)2]·3H2O, features a polymeric anion with a centrosymmetric Ce2O2 core and a Ce⋯Ce distance of 4.3625 (4) Å. The anions form ribbons {[Ce2(C4H4O4S)4(H2O)2]2−}n extending along [100]. The doubly protonated piperazinium cations reside on centers of inversion and link the polymeric ribbons via N—H⋯O hydrogen bonding. Each CeIII cation is ten-coordinated by an O2S donor set from two tridentate sulfanediyldiacetate (tda) ligands, one water mol­ecule and three other tda O donors from adjacent {Ce(tda)2(H2O)} units in a distorted bicapped cubic environment. Additional O—H⋯O hydrogen bonding involving the coordinated and solvent water mol­ecules is also present. H atoms of the crystal water molecules could not be located and were not included in the refinement

Crystal Engineering and Molecular Architecture

The aim of this paper is to provide a link between research projects and education to optimize teaching and learning of related subjects. In a research project, three compounds including an intermolecular proton transfer compound, a hydrated carboxylic acid, and a metallic complex were synthesized, all of them have non-covalent interactions such as O−H∙∙∙O, O−H∙∙∙N and C−H∙∙∙O hydrogen bonds as well as van der Waals forces and π-π stacking resulting to different supramolecular structures. The structures of compounds are characterized by single crystal X-ray diffraction method. The classic concepts and definitions related to the subject are given in the last section

Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithelial Homeostasis and Ameliorates Colitis

Gut microbiota plays a crucial role in inflammatory bowel diseases (IBD) and can potentially prevent IBD through microbial-derived metabolites, making it a promising therapeutic avenue. Recent evidence suggests that despite an unclear underlying mechanism, red cabbage juice (RCJ) alleviates Dextran Sodium Sulfate (DSS)-induced colitis in mice. Thus, the study aims to unravel the molecular mechanism by which RCJ modulates the gut microbiota to alleviate DSS-induced colitis in mice. Using C57BL/6J mice, we evaluated RCJ’s protective role in DSS-induced colitis through two cycles of 3% DSS. Mice were daily gavaged with PBS or RCJ until the endpoint, and gut microbiota composition was analyzed via shotgun metagenomics. RCJ treatment significantly improved body weight (p ≤ 0.001), survival in mice (p \u3c 0.001) and reduced disease activity index (DAI) scores. Further, RCJ improved colonic barrier integrity by enhancing the expression of protective colonic mucins (p \u3c 0.001) and tight junction proteins (p ≤ 0.01) in RCJ + DSS-treated mice compared to the DSS group. Shotgun metagenomic analysis revealed an enrichment of short-chain fatty acids (SCFAs)-producing bacteria (p \u3c 0.05), leading to increased Peroxisome Proliferator-Activated Receptor Gamma (PPAR-ү ) activation (p ≤ 0.001). This, in turn, resulted in repression of the nuclear factor кB (NFкB) signaling pathway, causing decreased production of inflammatory cytokines and chemokines. Our study demonstrates colitis remission in a DSS-induced mouse model, showcasing RCJ as a potential modulator for gut microbiota and metabolites, with promising implications for IBD prevention and treatment

Poly[[piperazine-1,4-dium [diaqua-tetra-kis-(μ-sulfanediyldiacetato)-dicerate(III)]] trihydrate].

The title compound, (C(4)H(12)N(2))[Ce(2)(C(4)H(4)O(4)S)(4)(H(2)O)(2)]·3H(2)O, features a polymeric anion with a centrosymmetric Ce(2)O(2) core and a Ce⋯Ce distance of 4.3625 (4) Å. The anions form ribbons {[Ce(2)(C(4)H(4)O(4)S)(4)(H(2)O)(2)](2-)}(n) extending along [100]. The doubly protonated piperazinium cations reside on centers of inversion and link the polymeric ribbons via N-H⋯O hydrogen bonding. Each Ce(III) cation is ten-coordinated by an O(2)S donor set from two tridentate sulfanediyldiacetate (tda) ligands, one water mol-ecule and three other tda O donors from adjacent {Ce(tda)(2)(H(2)O)} units in a distorted bicapped cubic environment. Additional O-H⋯O hydrogen bonding involving the coordinated and solvent water mol-ecules is also present. H atoms of the crystal water molecules could not be located and were not included in the refinement