Transient radio emisison from SAX J1808.4-3658

We report on the detection of radio emission from the accretion-powered X-ray millisecond pulsar SAX J1808.4-3658, using the Australia Telescope Compact Array. We detected a ~0.8 mJy source at the position of SAX J1808.4-3658 on 1998 April 27, approximately one day after the onset of a rapid decline in the X-ray flux; no such source was seen on the previous day. We consider this emission to be related to the radio emission from other X-ray binaries, and is most likely associated with an ejection of material from the system. No radio emission was detected at later epochs, indicating that if SAX J1808.4-3658 is a radio pulsar during X-ray quiescence then its monochromatic luminosity must be less than L(1.4 GHz) ~6 mJy/kpc^2.Comment: 6 pages, uses emulateapj.sty, one embedded PS figure. Accepted to ApJ Letter

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection

Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection. However, the role of astrocytes in innate immune responses of the BBB during viral infection of the CNS remains to be fully elucidated. Here, we have demonstrated that type I IFNAR signaling in astrocytes regulates BBB permeability and protects the cerebellum from infection and immunopathology. Mice with astrocyte-specific loss of IFNAR signaling showed decreased survival after West Nile virus infection. Accelerated mortality was not due to expanded viral tropism or increased replication. Rather, viral entry increased specifically in the hindbrain of IFNAR-deficient mice, suggesting that IFNAR signaling critically regulates BBB permeability in this brain region. Pattern recognition receptors and IFN-stimulated genes had higher basal and IFN-induced expression in human and mouse cerebellar astrocytes than did cerebral cortical astrocytes, suggesting that IFNAR signaling has brain region–specific roles in CNS immune responses. Taken together, our data identify cerebellar astrocytes as key responders to viral infection and highlight the existence of distinct innate immune programs in astrocytes from evolutionarily disparate regions of the CNS

First‐in‐Human Study of the Safety and Efficacy of TOL101 Induction to Prevent Kidney Transplant Rejection

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107383/1/ajt12698.pd

Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells

This work was funded in part by Science Foundation Ireland under Grant No. 11/PI/08, the National Key Basic Research Program (973 Project) (Nos. 2011CB933101 and 2015CB931802), National Natural Scientific Fund (Nos. 81225010 and 81327002), 863 project of China (Nos. 2012AA022703 and 2014AA020700), Shanghai Science and Technology Fund (No. 13NM1401500). E.R.E. was supported in part by NIH R01 GM49039. J.C. acknowledges Marie Curie International Outgoing Fellowship (FP7-PEOPLE-2013-IOF, Project No. 626386) and F.T. for Marie Curie grant agreement (PIEF-GA-2012-332-332462

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2). Our study has defined the origin of these macrophages by showing Gr1+ inflammatory monocytes (IMs) are preferentially recruited to pulmonary metastases but not primary mammary tumors, a process also found for human IMs in pulmonary metastases of human breast cancer cells. The recruitment of these CCR2 (receptor for chemokine CCL2) expressing IMs and subsequently MAMs and their interaction with metastasizing tumor cells is dependent on tumor and stromal synthesized CCL2 (FigS1). Inhibition of CCL2/CCR2 signaling using anti-CCL2 antibodies blocks IM recruitment and inhibits metastasis in vivo and prolongs the survival of tumor-bearing mice. Depletion of tumor cell-derived CCL2 also inhibits metastatic seeding. IMs promote tumor cell extravasation in a process that requires monocyte-derived VEGF. CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer (Fig S2)(3-6). Our data provides the mechanistic link between these two clinical associations and indicates new therapeutic targets for treating metastatic breast disease

The Impacts of Energy Efficiency and Consumption on GDP in the Euro Area

This paper analyzes the aggregate data of the Euro Area to determine how GDP per unit of energy is affected by the use of common energy sources. Time series data from 1980 to 2005 is used to show the change in how energy is used compared to the growth of GDP. It is revealed in this paper that the consumption of efficient forms of energy is highly correlated to GDP growth and the use of inefficient energy sources leads to less growth

Methods for Investigating and Advancing Active Transportation in New Hampshire

Access to and use of active transportation opportunities are central to the creation of sustainable communities in the state of New Hampshire (NH). To further active transportation participation in the state, Plymouth State University partnered with NH’s Department of Transportation and regional planning commissions to better understand barriers to bicycling throughout NH. Participatory GIS mapping (PPGIS) surveys in two case study regions of NH captured perceived barriers to bicycling, which validated Level of Traffic Stress (LTS) roads models. Additional community and regional accessibility assessments utilized a Level of Traffic Stress model to identify gaps in the state’s bicycling network and prioritize roadways for improvement. The results of the PPGIS survey revealed few distinctions between regional perceptions of barriers to bikeability, supporting the application of bicycle prescriptions statewide. The survey also suggested that LTS-measured variables are among the most prominent barriers to bicycling engagement in NH. Planners can thus justify funding and prioritizing pro-bicycle roadway improvements informed by LTS model results, and, by extension, the accessibility analysis. This research provides planners, government officials, citizens, and advocacy groups with recommendations regarding the most effective processes for developing and implementing active transportation improvements throughout their communities

Spiritual Abuse in Augusta, Georgia: Reconciling the Spiritually Abused to the Local Church

The purpose of this action-based research project was to address the absence of a therapeutic process wherein pastoral counselors at Life Management Group (LMG) can responsibly attempt to reconcile spiritually abused Christians to a local church in Augusta, Georgia. One hundred percent of clients citing spiritual abuse in LMG’s pastoral counseling department were abstaining from any religious activity within a community of faith at the outset of this project. Data was researched at the international, national, state, and local levels. The researcher concluded that published research related to the topic of spiritual abuse is theoretical in nature only and not application based. The project intervention utilized interviews, questionnaires, weekly counseling sessions, and observations to gather information from fourteen participating LMG clients and ten partnered local churches to survey the problem of spiritual abuse, discover, and apply spiritual safety best practices. This action-based research project sought to bridge the application gap in spiritual abuse research by monitoring real-time progress, milestones, and results of LMG clients attempting to reintegrate into a local church. The results of this research prove helpful to the pastoral counselors and church leaders in the city of Augusta as they consider implementing the concepts herein. The project revealed that the counselor-church partnership, combined with client-focused therapeutic modalities that address spiritual abuse, is successful in promoting client-church reconciliation. The results indicate that pastoral counselors can positively impact the success of spiritually abused Christians attempting to reintegrate into a local church

The Radio Variability of the Gravitational Lens PMN J1838-3427

We present the results of a radio variability study of the gravitational lens PMN J1838-3427. Our motivation was to determine the Hubble constant by measuring the time delay between variations of the two quasar images. We monitored the system for 4 months (approximately 5 times longer than the expected delay) using the Australia Telescope Compact Array at 9 GHz. Although both images were variable on a time scale of a few days, no correlated intrinsic variability could be identified, and therefore no time delay could be measured. Notably, the fractional variation of the fainter image (8%) was greater than that of the brighter image (4%), whereas lensed images of a point source would have the same fractional variation. This effect can be explained, at least in part, as the refractive scintillation of both images due to the turbulent interstellar medium of the Galaxy.Comment: To appear in AJ (8 pages, including 4 figures