Perceptual difficulties in reading

Thesis (Ed.M.)--Boston Universit

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.

BACKGROUND: Interferon-gamma (IFNγ) is of key importance in the immune response to Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and novel treatment strategies are needed. We performed a randomized controlled trial to determine whether addition of IFNγ to standard therapy increased the rate of clearance of cryptococcal infection in HIV-associated cryptococcal meningitis. METHODS: Patients were randomized to amphotericin B 1 mg/kg per day and 5FC 100 mg/kg per day for 2 weeks (standard therapy), standard therapy and IFNγ1b 100 μg days 1 and 3 (IFNγ two doses), or standard therapy and IFNγ1b 100 μg days 1, 3, 5, 8, 10 and 12 (IFNγ six doses). Primary outcome was rate of clearance of cryptococcus from the cerebrospinal fluid (CSF) (early fungicidal activity, EFA) calculated from serial quantitative cultures, previously shown to be independently associated with survival. RESULTS: Rate of fungal clearance was significantly faster in IFNγ containing groups than with standard treatment. Mean EFA [log colony forming unit (CFU)/ml per day] was -0.49 with standard treatment, -0.64 with IFNγ two doses, and -0.64 with IFNγ six doses. Difference in EFA was -0.15 [confidence interval (95% CI) -0.02 to -0.27, P=0.02] between standard treatment and IFNγ two doses, and -0.15 (95% CI -0.05 to -0.26, P=0.006) between standard treatment and IFNγ six doses. Mortality was 16% (14/88) at 2 weeks and 31% (27/87) at 10 weeks, with no significant difference between groups. All treatments were well tolerated. CONCLUSION: Addition of short-course IFNγ to standard treatment significantly increased the rate of clearance of cryptococcal infection from the CSF, and was not associated with any increase in adverse events. Two doses of IFNγ are as effective as six doses

Women and Work

128 pages : illustrations (some color, including maps) ; 22 cm. Series: The new democracy Designed and produced by Adprint Ltd London ; Copyright 1945 by Adprint Ltd London ... --title page verso. First published by Nicholson & Watson in association with Wells Gardner Darton & Co Ltd, London, 1945 --title page verso. Contents: The scope of women\u27s work. The wartime revolution -- The rise of the dependent family -- The effect of marriage -- Law and custom -- The work women do. Changes in numbers and jobs -- The middle-class woman -- Woman\u27s dual role. Differences in pay -- Do women need less? -- The economic factors -- Workers and wives -- Public opinion and the married woman worker -- Women and work in the post-war world. Some effects of the war -- The double-job woman -- The part-time worker -- Women and the community. Photographic Editor: Paul Rotha. Reading list : page 128. Information graphics. Book has ink property stamp on front endsheet: Ministry of Labour & National Service, Factory Department, Information Service. Case binding.https://digitalcommons.risd.edu/specialcollections_books_graphicdesign/1003/thumbnail.jp

Using a social justice lens to explore the possibilities and limitations of flexible learning provision in a South African TVET college

DATA AVAILABILITY : The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.In its preamble, the Department of Higher Education and Training’s (DHET) strategic plan for 2015 to 2020 identified ways to expand access to education and training. However, in South Africa, Technical and Vocational Education and Training (TVET) colleges’ enrolment growth is inhibited by inadequate physical infrastructure and a shortage of additional and relevant human resources (DHET, 2018). The draft Open Learning Policy Framework for the Post-School Education and Training (2017) recommends that the principle of flexibility be applied to increase student access and support their success. This exploratory case study focuses on possibilities and limitations of flexible learning provision at a selected TVET college in the Free State province. It adopts Nancy Fraser’s (1995, 2005) theory of social justice, which emphasizes parity of participation with respect to economic, cultural and political dimensions, to discuss ways in which flexible learning is socially just. COVID-19 lockdowns severely curtailed this study to virtual interviews with two institutional managers only, as students were not readily available. The transcripts were subsequently coded along Fraser’s three dimensions of social justice. The study demonstrates that flexible learning provision responded to the economic dimensions of transport poverty by providing access to curriculum content via online platforms, radio broadcasts and hardcopy materials deposited for collection at selected physical destinations. In relation to cultural parity, it reveals that the college provides a pedagogically responsive intervention programme as a second opportunity for students to succeed. Politically, the study indicates that assessment practices at the college are exclusionary due to national assessment policies that constrain flexibility. This chapter contributes towards understanding the practices and policies that influence flexible learning provision as an aspirational form of open learning as well as the complex ways in which social injustices are entangled in the South African PSET sector.The South African Department of Higher Education and Training.https://www.scienceopen.com/hosted-document?doi=10.47622/9781928502425_3am2023Education InnovationSDG-04:Quality Educatio

Pratos e mais pratos: louças domésticas, divisões culturais e limites sociais no Rio de Janeiro, século XIX

Reply to ten comments on a paper published in the last issue of this journal. The discussion follows along six main lines: History museums, identity, ideology and the category of nation; the need of material collections and their modalities: patrimonial, operational, virtual; theater versus laboratory; visitors and their ambiguities; Public History: the museum and the academy.Resposta aos comentários de dez especialistas que contribuíram no debate de texto publicado no último número desta revista. A discussão orientou-se segundo seis tópicos principais: museus históricos, identidade, ideologia e a categoria de nação; a necessidade de acervos materiais e suas modalidades: acervo patrimonial, operacional, virtual; teatro versus laboratório; o público e suas ambigüidades; História Pública: o museu e a Academia

Dances, drills & entertainments.

Mode of access: Internet