Suitability of new Information and Communication Technologies for the increase of the internationality of research and development - opportunities and limits

Die vorliegende Arbeit betrachtet den Zusammenhang zwischen der Internationalisierung unternehmensinterner Forschungs- und Entwicklungsaktivitäten sowie neuer Informations- und Kommunikationstechnik. Es lässt sich feststellen, dass der Bereich der Forschung und Entwicklung bisher nicht in dem Maße internationalisiert ist, wie dies etwa bei anderen Funktionsbereichen festzustellen ist. Neue Informations- und Kommunikationstechnik erlaubt hingegen einen weitreichend ungehinderten grenzüberschreitenden Informationsaustausch. Auf Basis des Informationsverarbeitungsansatzes werden Aussagen bezüglich der Möglichkeiten und Grenzen der neuen Informations - und Kommunikationstechnik in bezug auf eine Erhöhung der Internationalität von Forschungs- und Entwicklungsaktivitäten generiert. Hierzu werden einerseits Barrieren der Internationalisierung, andererseits typische Konfigurationsmuster internationaler F&E-Aktivitäten untersucht.This study deals with the connection between the internationalization of corporate research and development activities on the one hand and new information and communication technologies on the other hand. It can be stated that research and development so far has not been internationalized to the extent witch has been perceived in other functional areas. New information and communication technologies, however, permit an extensively unhindered transnational information exchange. Based on the information processing theory statements are generated regarding the opportunities and limits of the new information and communication technologies in the context of an increase of the internationalization of research and development. In order to do so barriers of the internationalization are examined, as well as typical configuration samples of international R&D activities

Energy Optimization in NCFET-based Processors

Energy consumption is a key optimization goal for all modern processors. Negative Capacitance Field-Effect Transistors (NCFETs) are a leading emerging technology that promises outstanding performance in addition to better energy efficiency. Thickness of the additional ferroelectric layer, frequency, and voltage are the key parameters in NCFET technology that impact the power and frequency of processors. However, their joint impact on energy optimization has not been investigated yet.In this work, we are the first to demonstrate that conventional (i.e., NCFET-unaware) dynamic voltage/frequency scaling (DVFS) techniques to minimize energy are sub-optimal when applied to NCFET-based processors. We further demonstrate that state-of-the-art NCFET-aware voltage scaling for power minimization is also sub-optimal when it comes to energy. This work provides the first NCFET-aware DVFS technique that optimizes the processor\u27s energy through optimal runtime frequency/voltage selection. In NCFETs, energy-optimal frequency and voltage are dependent on the workload and technology parameters. Our NCFET-aware DVFS technique considers these effects to perform optimal voltage/frequency selection at runtime depending on workload characteristics. Results show up to 90 % energy savings compared to conventional DVFS techniques. Compared to state-of-the-art NCFET-aware power management, our technique provides up to 72 % energy savings along with 3.7x higher performance

Longitudinal change in SARS-CoV-2 seroprevalence in 3-to 16-year-old children: the Augsburg Plus study

BACKGROUND: Currently, more than 30,200,000 COVID-19 cases have been diagnosed in Germany alone. However, data regarding prevalence of COVID-19 in children, both in Germany and internationally, are sparse. We sought to evaluate the number of infected children by measuring IgG antibodies. METHODS: Oropharyngeal swabs were collected between December 2020 and August 2021 to measure SARS-CoV-2, and capillary blood for the detection of SARS-CoV-2 antibodies (by rapid test NADAL® and filter paper test Euroimmun® ELISA); venous blood was taken for validation (Roche® ECLIA and recomLine Blot) in 365 German children aged 3–16 years from 30 schools and preschools. We used multiple serological tests because the filter paper test Euroimmun® ELISA performs better in terms of sensitivity and specificity than the rapid test NADAL®. The Roche® ECLIA test is used to detect SARS-CoV-2 spike protein, and the recomLine Blot test is used to rule out the possibility of infection by seasonal SARS-viruses and to test for specific SARS-CoV-2 proteins (NP, RBD and S1). In addition, one parent each (n = 336), and 4–5 teachers/caregivers (n = 90) per institution were tested for IgG antibodies from capillary blood samples. The total study duration was 4 months per child, including the first follow-up after 2 months and the second after 4 months. RESULTS: Of 364 children tested at baseline, 3.6% (n = 13) were positive for SARS-CoV-2 IgG antibodies using Euroimmun® ELISA. Seven children reported previously testing positive for SARS-CoV-2; each of these was confirmed by the Roche® Anti-SARS-CoV-2-ECLIA (antibody to spike protein 1) test. SARS-CoV-2 IgG antibodies persisted over a 4-month period, but levels decreased significantly (p = 0.004) within this timeframe. The median IgG values were 192.0 BAU/ml [127.2; 288.2], 123.6 BAU/ml [76.6; 187.7] and 89.9 BAU/ml [57.4; 144.2] at baseline, 2 months and 4 months after baseline, respectively. During the study period, no child tested positive for SARS-CoV-2 by oropharyngeal swab. A total of 4.3% of all parents and 3.7% of teachers/caregivers tested positive for IgG antibodies by Euroimmun® ELISA at baseline. CONCLUSION: We noted a rather low seroprevalence in children despite an under-reporting of SARS-CoV-2 infections. Measurement of IgG antibodies derived from capillary blood appears to be a valid tool to detect asymptomatic infections in children. However, no asymptomatic active infection was detected during the study period of 4 months in the whole cohort. Further data on SARS-CoV-2 infections in children are needed, especially in the group of <5-year-olds, as there is currently no licensed vaccine for this age group in Germany. The Robert Koch Institute’s Standing Commission on Vaccination (STIKO) recommended COVID-19 vaccination for 12–17 and 5–11 year olds in August 2021 and May 2022 respectively

Memory Latency Distribution-Driven Regulation for Temporal Isolation in MPSoCs

Temporal isolation is one of the most significant challenges that must be addressed before Multi-Processor Systems-on-Chip (MPSoCs) can be widely adopted in mixed-criticality systems with both time-sensitive real-time (RT) applications and performance-oriented non-real-time (NRT) applications. Specifically, the main memory subsystem is one of the most prevalent causes of interference, performance degradation and loss of isolation. Existing memory bandwidth regulation mechanisms use static, dynamic, or predictive DRAM bandwidth management techniques to restore the execution time of an application under contention as close as possible to the execution time in isolation. In this paper, we propose a novel distribution-driven regulation whose goal is to achieve a timeliness objective formulated as a constraint on the probability of meeting a certain target execution time for the RT applications. Using existing interconnect-level Performance Monitoring Units (PMU), we can observe the Cumulative Distribution Function (CDF) of the per-request memory latency. Regulation is then triggered to enforce first-order stochastical dominance with respect to a desired reference. Consequently, it is possible to enforce that the overall observed execution time random variable is dominated by the reference execution time. The mechanism requires no prior information of the contending application and treats the DRAM subsystem as a black box. We provide a full-stack implementation of our mechanism on a Commercial Off-The-Shelf (COTS) platform (Xilinx Ultrascale+ MPSoC), evaluate it using real and synthetic benchmarks, experimentally validate that the timeliness objectives are met for the RT applications, and demonstrate that it is able to provide 2.2x more overall throughput for NRT applications compared to DRAM bandwidth management-based regulation approaches