Strategies and Best Practices for Model-based Systems Engineering Adoption in Embedded Systems Industry

[Context] Model-based Systems Engineering (MBSE) advocates the integrated use of models throughout all development phases of a system development life-cycle. It is also often suggested as a solution to cope with the challenges of engineering complex systems. However, MBSE adoption is no trivial task and companies, especially large ones, struggle to achieve it in a timely and effective way. [Goal] We aim to discover what are the best practices and strategies to implement MBSE in companies that develop embedded software systems. [Method] Using an inductive-deductive research approach, we conducted 14 semi-structured interviews with experts from 10 companies. Further, we analyzed the data and drew some conclusions which were validated by an on-line questionnaire in a triangulation fashion. [Results] Our findings are summarized in an empirically validated list of 18 best practices for MBSE adoption and through a prioritized list of the 5 most important best practices. [Conclusions] Raising engineers’ awareness regarding MBSE advantages and acquiring experience through small projects are considered the most important practices to increase the success of MBSE adoption.BMBF, 01IS15058, Verbundprojekt SPEDiT: Software Platform Embedded Systems - Dissemination und Transfe

Should I stay or should I go? : On forces that drive and prevent MBSE adoption in the embedded systems industry

[Context] Model-based Systems Engineering (MBSE) comprises a set of models and techniques that is often suggested as solution to cope with the challenges of engineering complex systems. Although many practitioners agree with the arguments on the potential benefits of the techniques, companies struggle with the adoption of MBSE. [Goal] In this paper, we investigate the forces that prevent or impede the adoption of MBSE in companies that develop embedded software systems. We contrast the hindering forces with issues and challenges that drive these companies towards introducing MBSE. [Method] Our results are based on 20 interviews with experts from 10 companies. Through exploratory research, we analyze the results by means of thematic coding. [Results] Forces that prevent MBSE adoption mainly relate to immature tooling, uncertainty about the return-on-investment, and fears on migrating existing data and processes. On the other hand, MBSE adoption also has strong drivers and participants have high expectations mainly with respect to managing complexity, adhering to new regulations, and reducing costs. [Conclusions] We conclude that bad experiences and frustration about MBSE adoption originate from false or too high expectations. Nevertheless, companies should not underestimate the necessary efforts for convincing employees and addressing their anxiety

Weak Factors are Everywhere

Factor Sequences are stochastic double sequences indexed in time and cross-section which have a so called factor structure. The term was coined by Forni and Lippi (2001) who introduced dynamic factor sequences. We introduce the distinction between dynamic- and static factor sequences which has been overlooked in the literature. Static factor sequences, where the static factors are modeled by a dynamic system, are the most common model of macro-econometric factor analysis, building on Chamberlain and Rothschild (1983a); Stock and Watson (2002a); Bai and Ng (2002). We show that there exist two types of common components - a dynamic and a static common component. The difference between those consists of the weak common component, which is spanned by (potentially infinitely many) weak factors. We also show that the dynamic common component of a dynamic factor sequence is causally subordinated to the output under suitable conditions. As a consequence only the dynamic common component can be interpreted as the projection on the infinite past of the common innovations of the economy, i.e. the part which is dynamically common. On the other hand the static common component captures only the contemporaneous co-movement

Retrieval from mixed sampling frequency: generic identifiability in the unit root VAR

The “retrieval from mixed frequency sampling” approach based on blocking—described e.g., in Anderson et al. (Econom Theory 32:793–826, 2016a)—is concerned with retrieving an underlying high frequency model from mixed frequency observations. In this paper, we investigate parameter-identifiability in the Johansen (Likelihood-based inference in cointegrated vector autoregressive models. Oxford University Press, Oxford, 1995) vector error correction model for mixed frequency data. We prove that from the second moments of the blocked process after taking differences at lag N (N is the slow sampling rate), the parameters of the high frequency system are generically identified. We treat the stock and the flow case

Traumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse

The majority of traumatic encephalopathy syndrome (TES) cases have been reported in former contact sport athletes. This is the first case with TES in a 19-year-old male patient with progressive cognitive decline after daily domestic physical violence through repeated hits to the head for 15 years. The patient presented with a moderate depressive episode and progressive cognitive decline. Tau positron emission tomography (PET) with 220 MBq of [18F]PI-2620 revealed increased focal signal at the frontal and parietal white/gray matter border. Brain magnetic resonance imaging (MRI) showed a cavum septum pellucidum, reduced left-sided hippocampal volume, and a left midbrain lesion. Cerebrospinal fluid results showed elevated total and p-tau. Neurocognitive testing at admission showed memory deficits clearly below average, and hampered dysfunctions according to the slow processing speed with a low mistake rate, indicating the acquired, thus secondary, attentional deficits. We diagnosed the patient with a TES suggestive of chronic traumatic encephalopathy and classified him as having subtle/mild functional limitation with a most likely transition to mild dementia within the TES criteria. This report underlines child abuse as a relevant criterion in diagnosing TES in cases with repetitive hits to the head. In addition to clinical markers, we show the relevance of fluid tau biomarkers and tau-PET to support the diagnosis of TES according to the recently published diagnosis criteria for TES

Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome

Protein homeostasis (proteostasis) is essential for the cell and is maintained by a highly conserved protein quality control (PQC) system, which triages newly synthesized, mislocalized and misfolded proteins. The ubiquitin-proteasome system (UPS), molecular chaperones, and co-chaperones are vital PQC elements that work together to facilitate degradation of misfolded and toxic protein species through the 26S proteasome. However, the underlying mechanisms are complex and remain partly unclear. Here, we provide an overview of the current knowledge on the co-chaperones that directly take part in targeting and delivery of PQC substrates for degradation. While J-domain proteins (JDPs) target substrates for the heat shock protein 70 (HSP70) chaperones, nucleotide-exchange factors (NEFs) deliver HSP70-bound substrates to the proteasome. So far, three NEFs have been established in proteasomal delivery: HSP110 and the ubiquitin-like (UBL) domain proteins BAG-1 and BAG-6, the latter acting as a chaperone itself and carrying its substrates directly to the proteasome. A better understanding of the individual delivery pathways will improve our ability to regulate the triage, and thus regulate the fate of aberrant proteins involved in cell stress and disease, examples of which are given throughout the review

Anterior cruciate ligament abnormalities are associated with accelerated progression of knee joint degeneration in knees with and without structural knee joint abnormalities: 96-month data from the Osteoarthritis Initiative

ObjectiveTo compare progression over 8 years in knee compositional cartilage degeneration and structural joint abnormalities in knees with different types of anterior cruciate ligament (ACL) abnormalities over 8 years.MethodBaseline MR images of the right knees of 1899 individuals of the Osteoarthritis Initiative (OAI) with no evidence of or mild to moderate radiographic osteoarthritis were assessed for nontraumatic ACL abnormalities. The knees of 91 individuals showed nontraumatic ACL abnormalities (age 60.6 ± 9.8 y, 46 females; mucoid degeneration (MD), N = 37; complete tear (CT), N = 22; partial tear (PT), N = 32) and were frequency-matched to 91 individuals with normal ACL. MRIs were assessed for knee joint abnormalities using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) and cartilage T2 mapping at baseline, 4- and 8-year follow-up.ResultsOver 8 years, cartilage T2 values of the medial tibia showed a significantly greater increase in individuals with MD, PT or CT compared to those with normal ACL (adjusted rate of change/year [95% confidence interval], normal ACL: 0.06 [0.01, 0.23], MD: 0.34 [0.07, 0.73], PT, 0.21 [0.02, 0.33], CT, 0.51 [0.16, 0.78]), indicating an association of ACL abnormalities and an increased progression rate of cartilage degeneration in subjects with and without knee joint degeneration. This effect was also seen in cartilage T2 values averaged over all compartments (normal ACL: 0.08 [0.05, 0.20] vs abnormal ACL: 0.27 [0.06, 0.56]).ConclusionsOver 8 years, higher progression rates of cartilage degeneration, especially in the medial tibia, were associated with ACL abnormalities compared to those with normal ACL, in subjects with and without knee joint abnormalities

The Curved MCA: Influence of Vessel Anatomy on Recanalization Results of Mechanical Thrombectomy after Acute Ischemic Stroke

ABSTRACT BACKGROUND AND PURPOSE: Vessel anatomy is assumed to influence results of endovascular mechanical thrombectomy using stent retrievers. The purpose of this study was to analyze the influence of vessel curvature on recanalization results in patients with acute ischemic stroke caused by large-vessel occlusion

CT-like images based on T1-weighted gradient echo MRI sequences for the assessment of fractures of the hand and wrist compared to CT

Objective To evaluate the performance of a 3D T1-weighted gradient-echo (3D T1GRE) computed tomography (CT)-like magnetic resonance imaging (MRI) sequence for detecting and assessing wrist and hand fractures compared to conventional CT. Methods Subjects with acute wrist or hand fracture in CT underwent additional 3 T MRI including a CT-like 3D T1GRE sequence and were compared to patients without fractures. Two radiologists assessed fracture morphology on both modalities according to the Arbeitsgemeinschaft Osteosynthese (AO) and graded image quality and diagnostic confidence on a 5-point Likert scale. Besides diagnostic test evaluation, differences in image quality and diagnostic confidence between CT-like MRI and CT were calculated using the Wilcoxon test. Agreement of AO classification between modalities and readers was assessed using Cohen’s Kappa. Results Twenty-eight patients with 43 fractures and 43 controls were included. Image quality (3D T1GRE 1.19 ± 0.37 vs. CT 1.22 ± 0.42; p = 0.65) and diagnostic confidence (3D T1GRE 1.28 ± 0.53 vs. CT 1.28 ± 0.55; p = 1.00) were rated excellent for both modalities. Regarding the AO classification, intra- (rater 1 and rater 2, κ = 0.89; 95% CI 0.80–0.97) and interrater agreement were excellent (3D T1GRE, κ = 0.82; 95% CI, 0.70–0.93; CT, κ = 0.85; 95% CI, 0.75–0.94). CT-like MRI showed excellent sensitivity, specificity and accuracy for fracture detection (reader 1: 1.00, 0.92, 0.96; reader 2: 0.98, 0.94, 0.96). Conclusion CT-like MRI is a comparable alternative to CT for assessing hand and wrist fractures, offering the advantage of avoiding radiation exposure