Egg production of Baltic cod (Gadus morhua) in relation to variable sex ratio, maturity, and fecundity

Observed fluctuations in relative fecundity of Eastern Baltic cod (Gadus morhua L.) were related to food availability during the main feeding period and were used to develop a predictive model that explained 72% of the interannual variations in fecundity. Time series of sex ratios, maturity ogives, and relative fecundity were combined with mean weights-at-age and stock sizes from an analytical multispecies model to estimate the potential egg production (PEP). Relationships between PEP and independent estimates of realized daily and seasonal egg production from egg surveys were highly significant. The difference between estimates of potential and realized seasonal egg production was of a magnitude corresponding to the expected loss of eggs as a result of atresia, fertilization failure, and early egg mortality. The removal of interannual variability in sex ratio, maturity, and fecundity on estimates of PEP deteriorated the relationships in all three cases. PEP proved to be superior to spawning stock biomass as measure of the reproductive potential in a stock-recruitment relationship of Eastern Baltic cod. PEP in combination with the reproductive volume explained 61% of the variation in year-class strength at age 2

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar

NeuroTec Sitem-Insel Bern: Closing the Last Mile in Neurology

Neurology is focused on a model where patients receive their care through repeated visits to clinics and doctor’s offices. Diagnostic tests often require expensive and specialized equipment that are only available in clinics. However, this current model has significant drawbacks. First, diagnostic tests, such as daytime EEG and sleep studies, occur under artificial conditions in the clinic, which may mask or wrongly emphasize clinically important features. Second, early detection and high-quality management of chronic neurological disorders require repeat measurements to accurately capture the dynamics of the disease process, which is impractical to execute in the clinic for economical and logistical reasons. Third, clinic visits remain inaccessible to many patients due to geographical and economical circumstances. Fourth, global disruptions to daily life, such as the one caused by COVID-19, can seriously harm patients if access to in-person clinical visits for diagnostic and treatment purposes is throttled. Thus, translating diagnostic and treatment procedures to patients’ homes will convey multiple substantial benefits and has the potential to substantially improve clinical outcomes while reducing cost. NeuroTec was founded to accelerate the re-imagining of neurology and to promote the convergence of technological, scientific, medical and societal processes. The goal is to identify and validate new digital biomarkers that can close the last mile in neurology by enabling the translation of personalized diagnostics and therapeutic interventions from the clinic to the patient’s home

Molecular links between whitesand ecosystems and blackwater formation in the Rio Negro watershed

Tropical rivers such as the Rio Negro constitute a major portion of the global aquatic flux of dissolved organic carbon (DOC) entering the ocean, but the exact amount, source contributions and fate of terrestrial DOC remain unknown. We investigated the role of valley and upland whitesand ecosystems (WSEs) and terra firme plateaus in forming blackwater tributaries in the Rio Negro basin to develop novel constraints for the terrestrial export of carbon. 5709 molecular markers from ground- and surface waters of two contrasting valley and upland sites feeding Rio Negro tributaries were identified by ultrahigh resolution mass spectrometry (FT-MS), analyzed by multivariate statistics and compared to known Rio Negro markers. In a Principal Coordinates Analysis, valley and upland DOC molecular composition differed by 78% from plateau DOC, which was characterized by reworked, aliphatic and unsaturated N- and S-containing molecules, while valley and upland DOC contained mainly condensed aromatics, aromatics and oxidized unsaturated structures. Valley and upland samples differed by 10% in molecular DOC composition and by their isotopic content (14C of SPE-DOC, 18O and 2H of water) which indicated differences in hydrology and C turnover. Against expectation, markers of widespread whitesand valleys did not emerge as a major source of Rio Negro markers, but specific upland markers did. Pubchem suggested chromene and benzofuran structures as promising candidates for further study. Our findings indicate that the export of molecular markers diverges from expected transport-limited DOC behavior, and thereby opens new avenues for source annotation beyond DOC quantity. Terrestrial DOC from upland whitesand areas is a major source of specific blackwater molecules missing in the regional ecosystem C balance, whereas C export from the whitesand valleys and especially from terra firme plateaus represents mainly recycled and transformed carbon not directly affecting the ecosystem C balance and possibly, the watersheds downstream molecular signature. Our study highlights the potential of high-resolution techniques to constrain carbon balances of ecosystems and landscapes by novel molecular markers. A comparison with other terrestrial DOM datasets indicated molecular similarities with temperate acidic soils and tropical rivers that warrant further analysis of common DOM markers. Implications, limitations, and future challenges are discussed in the light of potential applications of diagnostic molecular links for DOC source annotation and estimation of terrestrial DOM export in the land-to-ocean continuum.ISSN:0016-7037ISSN:1872-953

Creating Pan-Karen Identity: The Wrist Tying Ceremony in the United States

A movement to unite all Karen-language speaking people under the banner of a distinct and unified Karen identity has been afoot for more than a century. Buddhist and Christian Karens from Burma, now living in Fort Wayne, Indiana, USA, are forging – and contesting – a universal Karen identity through the celebration of the “traditional” wrist tying ceremony. This articulation of pan-Karen identity is an example of Baumann and Gingrich\u27s (2004) theory of identity construction, which they call a “grammar of encompassment.” This case study shows that the theory, which claims that instances of encompassment are often contested by the encompassed (that is, the subordinate people whose alterity is denied), must be extended. In the United States, it is the encompassers (that is, the Christians who have greater economic and political power) who are the most deeply troubled by the denial of difference demanded by the discourse of encompassment

Mortality in migrants living with HIV in western Europe (1997-2013): A collaborative cohort study

Background: Many migrants face adverse socioeconomic conditions and barriers to health services that can impair timely HIV diagnosis and access to life-saving treatments. We aimed to assess the differences in overall mortality by geographical origin in HIV-positive men and women using data from COHERE, a large European collaboration of HIV cohorts from 1997 to 2013. Methods: In this observational cohort study, we included HIV-positive, antiretroviral-naive people accessing care in western Europe from COHERE. Individuals were eligible if enrolled in a cohort that collected information on geographical origin or ethnic origin from Jan 1, 1997, to March 19, 2013, aged 18-75 years, they had available information about sex, they were not infected perinatally or after the receipt of clotting factor concentrates, and were naive to combination antiretroviral therapy at cohort entry. Migrants' origins were grouped into seven regions: western Europe and similar countries (Australia, Canada, New Zealand, and the USA); eastern Europe; North Africa and the Middle East; sub-Saharan Africa; Latin America; the Caribbean; and Asia and the rest of Oceania (excluding Australia and New Zealand). Crude and adjusted mortality rate ratios were calculated by use of Poisson regression stratified by sex, comparing each group with the native population. Multiple imputation with chained equations was used to account for missing values. Findings: Between Oct 25, 1979, and March 19, 2013, we recruited 279 659 individuals to the COHERE collaboration in EuroCoord. Of these 123 344 men and 45 877 women met the inclusion criteria. Our data suggested effect modification by transmission route (pinteraction=0·12 for men; pinteraction=0·002 for women). No significant difference in mortality was identified by geographical origin in men who have sex with men. In heterosexual populations, most migrant men had mortality lower than or equal to that of native men, whereas no group of migrant women had mortality lower than that in native women. High mortality was identified in heterosexual men from Latin America (rate ratio [RR] 1·46, 95% CI 1·00-2·12, p=0·049) and heterosexual women from the Caribbean (1·48, 1·29-1·70, p<0·0001). Compared with that in the native population, mortality in injecting drug users was similar or low for all migrant groups. Interpretation: Characteristics of and risks faced by migrant populations with HIV differ for men and women and for populations infected heterosexually, by sex between men, or by injecting drug use. Further research is needed to understand how inequalities are generated and maintained for the groups with higher mortality identified in this study. Funding: EuroCoord

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis