5 research outputs found
Diverting epithelial-to-mesenchymal transition to transform cancer cells to adipocytes: A promising strategy to stop metastasis.
Circulating leptin, soluble leptin receptor and free leptin index in critically ill patients with sepsis: a prospective observational study
BACKGROUND: Leptin, the prototype adipokine, exerts immunomodulatory
actions being implicated in inflammatory responses during sepsis.
Clinical evidence regarding its role in sepsis has been contradictory,
while free leptin has not been studied. The aim of this study was to
jointly investigate circulating total leptin, its soluble receptor
(sOB-R), and free leptin, as well as their kinetics in critically ill
patients with sepsis regarding their diagnostic and prognostic value.
METHODS: In a prospective study, serum total leptin, sOB-R and free
leptin index (FLI) were determined in 102 critically ill patients with
sepsis within 48 hours from sepsis onset and one week after enrollment,
and in 102 age and gender-matched healthy controls.
RESULTS: Upon enrolment, total leptin, sOB-R and FLI were significantly
higher in septic patients compared to controls and they were positively
correlated with sepsis severity scores, while they presented a
significant decrease during the first week (P<0.001). The decrease in
total leptin and sOB-R was significantly higher in patients with sepsis
compared to septic shock and in survivors compared to non-survivors at
28 days (P<0.001). Higher serum total leptin was independently
associated with survival at 28 days (enrollment: HR 0.86, P=0.03; one
week after: HR 0.77, P<0.001). Higher kinetics of total leptin (but not
FLI) was independently associated with survival after adjustment (HR:
0.48, P=0.001).
CONCLUSIONS: Higher circulating total leptin and its higher kinetics
during the first week from sepsis onset independently predict 28-day
survival in critically ill patients. Free leptin did not present any
additional diagnostic and prognostic value in sepsis
Lower circulating omentin-1 is independently linked to subclinical hypothyroidism reflecting cardiometabolic risk: an observational case-control and interventional, longitudinal study
Omentin-1, a newly discovered adipokine, is implicated in the modulation of the adipose phenotype, ameliorating systemic metabolism and exhibiting anti-atherogenic, antioxidative, cardioprotective, anti-inflammatory and insulin-sensitizing properties. Our goal was to explore circulating omentin-1 in subclinical hypothyroidism (SH) and determine its correlations with cardiometabolic risk factors