The Evolution of Compact Binary Star Systems

We review the formation and evolution of compact binary stars consisting of white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and BHs are thought to be the primary astrophysical sources of gravitational waves (GWs) within the frequency band of ground-based detectors, while compact binaries of WDs are important sources of GWs at lower frequencies to be covered by space interferometers (LISA). Major uncertainties in the current understanding of properties of NSs and BHs most relevant to the GW studies are discussed, including the treatment of the natal kicks which compact stellar remnants acquire during the core collapse of massive stars and the common envelope phase of binary evolution. We discuss the coalescence rates of binary NSs and BHs and prospects for their detections, the formation and evolution of binary WDs and their observational manifestations. Special attention is given to AM CVn-stars -- compact binaries in which the Roche lobe is filled by another WD or a low-mass partially degenerate helium-star, as these stars are thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure

Numerical simulations of dense water cascading on a steep slope

The sinking of dense shelf waters down the continental slope (or "cascading") contributes to oceanic water mass formation and carbon cycling. Cascading over steep bottom topography is studied here in numerical experiments using POLCOMS, a 3-D ocean circulation model using a terrain-following s-coordinate system. The model setup is based on a laboratory experiment of a continuous dense water flow from a central source on a conical slope in a rotating tank. The governing parameters of the experiments are the density difference between plume and ambient water, the flow rate, the speed of rotation and (in the model) diffusivity and viscosity. The descent of the dense flow as characterized by the length of the plume as a function of time is studied for a range of parameters. Very good agreement between the model and the laboratory results is shown in dimensional and nondimensional variables. It is confirmed that a hydrostatic model is capable of reproducing the essential physics of cascading on a very steep slope if the model correctly resolves velocity veering in the bottom boundary layer. Experiments changing the height of the bottom Ekman layer (by changing viscosity) and modifying the plume from a 2-layer system to a stratified regime (by enhancing diapycnal diffusion) confirm previous theories, demonstrate their limitations and offer new insights into the dynamics of cascading outside of the controlled laboratory condition

Hydrodynamic Modelling of Mesoscale Eddies in the Black Sea

A three dimensional structure of mesoscale circulation in the Black Sea is simulated using the Proudman Oceanographic Laboratory Coastal Ocean Modelling System. A number of sensitivity tests reveal the response of the model to changes in the horizontal resolution, time steps, and diffusion coefficients. Three numerical grids are examined with x-fine (3.2 km), fine (6.7 km) and coarse (25 km) resolution. It is found that the coarse grid significantly overestimates the energy of the currents and is not adequate even for the study of basin-scale circulation. The x-fine grid, on the other hand, does not give significant advantages compared to the fine grid, and the latter is used for the bulk of simulations. The most adequate parameters are chosen from the sensitivity study and used to model both the basin-scale circulation and day-to-day variability of mesoscale currents for the months of May and June of 2000. The model is forced with actual wind data every 6 h and monthly climatic data for evaporation, precipitation, heat fluxes and river run-off. The results of the fine grid model are compared favourably against the satellite imagery. The model adequately reproduces the general circulation and many mesoscale features including cyclonic and anticyclonic eddies, jets and filaments in different parts of the Black Sea. The model gives a realistic geographical distribution and parameters of mesoscale currents, such as size, shape and evolution of the eddies

The piercing of the Atlantic Layer by an Arctic shelf water cascade in an idealised study inspired by the Storfjorden overflow in Svalbard

A plume of dense brine-enriched water, resulting from sea ice production in the Storfjorden polynya (Svalbard), cascades into Fram Strait and encounters a layer of warm, saline Atlantic Water. In some years the plume continues to sink into the deep Fram Strait while in other years it remains at Atlantic Layer depths. It has been unclear what parameters control whether the plume pierces the Atlantic Layer or not. We use a high-resolution 3-D numerical ocean model (NEMO-SHELF) to simulate an idealised scenario where a cascade descends a conical slope into an ambient 3-layer stratification. The model uses 1 km horizontal resolution and a blend of s- and z coordinates with 42 layers in the vertical arranged to resolve the plume at the bottom. We vary the salinity ‘S’ and the flow rate ‘Q’ of the simulated Storfjorden overflow to investigate both strong and weak cascading conditions. In agreement with observations the model reproduces three regimes: (i) the plume is arrested within or just below the Atlantic Layer, (ii) the plume pierces the Atlantic Layer and continues to the bottom of the slope and an intermediate regime (iii) where a portion of the plume detaches from the bottom, intrudes into the Atlantic Layer while the remainder continues its downslope propagation. For our idealised case the cascading regime can be predicted from the initial values of S and Q. In those model experiments where the initial density of the overflow water is considerably greater than of the deepest ambient water mass we find that a cascade with high initial S does not necessarily reach the bottom if Q is low. Conversely, cascades with an initial density just slightly higher than the deepest ambient layer may flow to the bottom if the flow rate Q is high. A functional relationship between S/Q and the final depth level of plume waters is explained by the flux of potential energy (arising from the introduction of dense water at shallow depth) which, in our idealised setting, represents the only energy source for downslope descent and mixing

Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach

BACKGROUND: Kidney injuries provoke considerable adjustment of renal physiology, metabolism, and architecture to nephron loss. Despite remarkable regenerative capacity of the renal tissue, these adaptations often lead to tubular atrophy, interstial and glomerular scaring, and development of chronic kidney disease. The therapeutic strategies for prevention of the transition from acute kidney damage to a chronic condition are limited. The purpose of this study was to elucidate large-scale alterations of the renal cortex proteome in partially nephrecromized rats at an early stage of chronic kidney disease. METHODS: Sprague–Dawley 5/6 nephrectomized rats and sham-operated controls were sacrificed at day 28 post-surgery. To identify proteins with notable alteration of expression we applied a 2D-proteomics approach followed by mass-spectrometry. Altered expression of identified and related proteins was validated by Western blotting and immunohistochemistry. RESULTS: Proteins with increased levels of expression after partial nephrectomy were albumin and vimentin. Proteins with decreased expression were metabolic or mitochondrial. Western blotting analysis showed that the renal cortex of nephrectomized rats expressed decreased amount (by ~50%) of proteins from the inner mitochondrial compartment - the beta-oxidation enzyme MCAD, the structural protein GRP-75, and the oxidative phosphorylation protein COXIV. Mitochondrial DNA copy number was decreased by 30% in the cortex of PNx rats. In contrast, the levels of an outer mitochondrial membrane protein, VDAC1, remained unchanged in remnant kidneys. Mitochondrial biogenesis was not altered after renal mass ablation as was indicated by unchanged levels of PPARγ and PGC1α proteins. Autophagy related protein Beclin 1 was up-regulated in remnant kidneys, however the level of LC3-II protein was unchanged. BNIP3 protein, which can initiate both mitochondrial autophagy and cell death, was up-regulated considerably in kidneys of nephrecomized rats. CONCLUSIONS: The results of the study demonstrated that notable alterations in the renal cortex of 5/6 nephrectomized rats were associated with mitochondrial damage, however mitochondrial biogenesis and autophagy for replacement of damaged mitochondria were not stimulated. Accumulation of dysfunctional mitochondria after 5/6 nephrectomy may cause multiple adjustments in biosynthetic pathways, energy production, ROS signaling, and activation of pro-cell death regulatory pathways thus contributing to the development of chronic kidney disease