Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain

Chronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient. Inflammation and immunometabolism play roles in the pathophysiology of chronic pain disorders. Electrical neuromodulation approaches have shown a meaningful success in otherwise drug-resistant chronic pain conditions, including failed back surgery, neuropathic pain, and migraine. A literature review (PubMed, MEDLINE/OVID, SCOPUS, and manual searches of the bibliographies of known primary and review articles) was performed using the following search terms: chronic pain disorders, systemic inflammation, immunometabolism, prediction, biomarkers, metabolic disorders, and neuromodulation for chronic pain. Experimental studies indicate a relationship between the development and maintenance of chronic pain conditions and a deteriorated immunometabolic state mediated by circulating cytokines, chemokines, and cellular components. A few uncontrolled in-human studies found increased levels of pro-inflammatory cytokines known to drive metabolic disorders in chronic pain patients undergoing neurostimulation therapies. In this narrative review, we summarize the current knowledge and possible relationships of available neurostimulation therapies for chronic pain with mediators of central and peripheral neuroinflammation and immunometabolism on a molecular level. However, to address the needs for predictive factors and biomarkers, large-scale databank driven clinical trials are needed to determine the clinical value of molecular profiling

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Thesaurus antiquitatum et historiarum Italiae... Tomi noni, pars sexta...

Pertenece a la obra con tít. colectivo: Thesaurus antiquitatum et historiarum Italiae, Neapolis, Siciliae, Sardiniae, Corsicae, Melitae ... / Digeri atque edi olum coeptus Cura et Studio Joannis Georgii Graevii ; Nunc autem continuatus & ad finem persuetus Cum Praefationibus Petri Burmanni ... ; comprehensus voluminibus XLV ...Sign.: [ ]2, *-2*2, †-7†2*2, A-D4, E-K2; *4, A-O4; *4, A-B4; *2, A-G3; *2, 2*1, A-H4, I1; *2, A-C4, D2, E1; *4, 2*1, A-F4, G2; *2, A-E4Antep.Port. a dos tintas con grab. calc.Texto a dos col.Philiberti Pingonii ... Augustae Taurinorum ..., con port., sign. y pag. propias -- R.D. Petri Jofredi ... Nicaea Civitas Sacris Monumentis Illustrata ..., con port. sign. y pag. propias -- Benedicti Accolti ... Praestantia Virorrum sui aevi Dialogus ..., con port., sign. y pag. propias -- Petri Azarii ... Chronicon Gestorum in Lombardia ..., con port., sign. y pag. propias -- Fr. Andreae Bilii ... Historiae Patriae Libri Novem ..., con port., sign. y pag. propias -- Georgii Flori ... De Bello italico et Rebus Gallorum ..., con port., sign. y pag. propias -- Petri Pauli Bosche ... De Origine et Statu Bibliothecae Ambrosianae ..., con port., sign. y pag. propias -- P. D. Christofori Giarde ... Liberalium Disciplinarum Icones Symbolicae Bibliothecae Alexandrinae ..., con port., sign. y pag. propiasA 209/11

Thesaurus antiquitatum et historiarum Italiae... Tomi noni, pars prima

Pertenece a la obra con tít. colectivo: Thesaurus antiquitatum et historiarum Italiae, Neapolis, Siciliae, Sardiniae, Corsicae, Melitae ... / Digeri atque edi olum coeptus Cura et Studio Joannis Georgii Graevii ; Nunc autem continuatus & ad finem persuetus Cum Praefationibus Petri Burmanni ... ; comprehensus voluminibus XLV ...Sign.: [ ]2, *2, †-6†2, A-C4; *2, A-K4, L1; *4, A2, B1; [ ]1, *-4*4, 5*2, A-Z4, 2A-2Z4, 3A-3B4Antep.Port. a dos tintas con grab. calc.Texto a dos col.Front. calc.Benedicti di Falco ... Antiquitates Neapolis ..., con port., sign. y pag. propias -- Henrici Bacci ... Nova et Perfectissima Descriptio Regni Neapolitani ..., con port. sign. y pag. propias -- Antonius Sanfelicius ... Situ ac Origine Campaniae ..., con port., sign. y pag. propias -- Camilli Peregrinii ... Historia Principum Langobardorum ..., con port., sign. y pag. propiasA 209/11

Thesaurus antiquitatum et historiarum Italiae, Quo continentur Optimi quique Scriptores, Qui Bononiae, Urbium Status Ecclesiastici et Aliarum ad Mare Adriaticum ... Tomi septimi, pars prima

Pertenece a la obra con tít. colectivo: Thesaurus antiquitatum et historiarum Italiae, Neapolis, Siciliae, Sardiniae, Corsicae, Melitae ... / Digeri atque edi olum coeptus Cura et Studio Joannis Georgii Graevii ; Nunc autem continuatus & ad finem persuetus Cum Praefationibus Petri Burmanni ... ; comprehensus voluminibus XLV ..Sign.: [ ]2, *-2*4, †-7†2, 8†1, A-F4, G2; *2, A-B4, C2, D1; *2, A-D4; *4, A-E4, F-K2; *2, A4; *2, A-B4, *4, A-C4, D1; []1, *4, 2*2, A-Z4, 2A-2Z4, 3A-3P4Antep.Port. a dos tintas con grab. calc.Texto a dos col.Bartholomaei Dulcini ... De Bononiae Vario Statu ..., con port., sign. y pag. propias -- Jo. Baptistae Agocchi ... Fundatio et Dominium Antiquum Urbis Bononiae ... ..., con port. sign. y pag. propias -- Descriptio Inclytae et Felicissimae Civitatis Bononiae ..., con port., sign. y pag. propias -- Cynthii Joannis Baptistae Gyraldi ... De Ferraria ..., con port., sign. y pag. propias -- Alphonsi Cagnacini Fragmentum Historicum Antiquitatis ..., con port., sign. y pag. propias -- Hippolyti Angelerii ... Antiquitate Urbis Atestinae ..., con port., sign. y pag. propias -- Desiderii Spreti ... De Urbis Ravennae ..., con port., sign. y pag. propias -- Hieronymi Rubei ... Italicarum et Ravennatum Historiarum ..., con port., sign. y pag propiasA 209/10

Thesaurus antiquitatum et historiarum Italiae... Tomi noni, pars secunda...

Pertenece a la obra con tít. colectivo: Thesaurus antiquitatum et historiarum Italiae, Neapolis, Siciliae, Sardiniae, Corsicae, Melitae ... / Digeri atque edi olum coeptus Cura et Studio Joannis Georgii Graevii ; Nunc autem continuatus & ad finem persuetus Cum Praefationibus Petri Burmanni ... ; comprehensus voluminibus XLV ...Sign.: A4, B2; [ ]1, *5, 2*-4*2, A-Z4, 2A-2N4, 2O-2P2; [ ]1, *3, A-N4Antep.Port. a dos tintas con grab. calc.Texto a dos colCamilli Peregrinii ... Dissertationes de Veteri Significatu Vocis Portae ..., con port., sign. y pag. propias -- Camilli Peregrinii ... Dissertationes de Campania Felice ..., con port. sign. y pag. propias -- Julii Caesaris Capacii ... Antiquitates et Historia Neapolitanae ..., con port., sign. y pag. propiasA 209/11

Thesaurus antiquitatum et historiarum Italiae... Tomi noni, pars quinta...

Pertenece a la obra con tít. colectivo: Thesaurus antiquitatum et historiarum Italiae, Neapolis, Siciliae, Sardiniae, Corsicae, Melitae ... / Digeri atque edi olum coeptus Cura et Studio Joannis Georgii Graevii ; Nunc autem continuatus & ad finem persuetus Cum Praefationibus Petri Burmanni ... ; comprehensus voluminibus XLV ...Sign.: [ ]2, *4, 2*2, A-E4, F2, G1; *-2*4, A-O4, P2; *4, A-F4, G1; *2, A-N4, O2; *3, 2*4, 3*1, A-L4; *2, A-D4Antep.Port. a dos tintas con grab. calc.Texto a dos col.Lucii Camarrae ... De Teate Antiquo ..., con port., sign. y pag. propias -- Aes Redivivum Sive Tabula Aerea ..., con port. sign. y pag. propias -- D. Pauli Antonii de Tarsia ... Historiarum Cupersanensium ..., con port., sign. y pag. propias -- Gabrielis Barrii ... De Calabriae Antiquitate et Situ ..., con port., sign. y pag. propias -- Joannis Juvenis ... De Antiquitate et Varia Fortuna Tarentinorum ..., con port., sign. y pag. propias -- Antonii Galatei ... De Situ Japygiae Liber ..., con port., sign. y pag. propiasA 209/11