5 research outputs found
Reproductive Outcome after Hysteroscopic Metroplasty in Patients with Infertility and Recurrent Pregnancy Loss
Introduction: Reproductive outcome can be negatively affected in patients with congenital uterine anomalies (CUA), increasing the number of unsuccessful pregnancies and obstetric complications. Compared with the population with normally formed uterus, patients with CUA have higher abortion rate, higher fetal loss rate and decreased live birth rate. Hysteroscopic metroplasty (HM) is a standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies.Aim: The aim of the study was to analyze the reproductive outcome in group of patients with infertility and recurrent pregnancy loss and present CUA, before and after hysteroscopic metroplasty.Material and Methods: We analyzed 67 patients to whom 78 interventions hysteroscopic metroplasty were performed at the University Clinic of Obstetrics and Gynecology in Skopje during a two year period, between 01.01.2010 and 31.12.2011. Their reproductive outcome was monitored during a two-year period and the same group served as a control group, taking into account their previous reproductive history. Statistical analysis was performed using Chi-square test and p < 0.05 was considered to be statistically significant.Results: Most common CUA were types 5b and 6 represented by 88 %. In a follow up period of two years, 33 of the patients become pregnant. There was a statistically significant decrease of abortion rate from 92% to 21.2%, as well as an increase in the term delivery rate from 0% to 69.7%.Conclusion: Treatment with hysteroscopic metroplasty is significantly improving the reproductive outcome in patients with CUA and previous fetal loss
Π£ΡΠΏΠ΅ΡΠ½ΠΎ ΠΎΠ΄Π»ΠΎΠΆΡΠ²Π°ΡΠ΅ Π½Π° ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅ΡΠΎ Π½Π° Π²ΡΠΎΡΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ ΠΏΠΎ ΡΠ°Π½Π° ΡΡΠΏΡΡΡΠ° Π½Π° ΠΏΠ»ΠΎΠ΄ΠΎΠ²ΠΈΡΠ΅ ΠΎΠ±Π²ΠΈΠ²ΠΊΠΈ ΠΊΠ°Ρ ΠΏΡΠ²ΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ: ΠΏΡΠΈΠΊΠ°Π· Π½Π° ΡΠ»ΡΡΠ°Ρ
Twin pregnancies are high-risk pregnancies accompanied with multiple complications, such as: spontaneous abortion, preterm rupture of the membranes, preterm delivery, intrauterine death of one or both twins etc. There is no consensus about the management of twin pregnancies complicated with preterm rupture of the membranes of one twin and risk of preterm delivery. These cases are rarely found in the literature. We present a case of a 35 years old patient, hospitalized in a tertiary level institution, because of a diamniotic dichorionic twin pregnancy complicated with preterm rupture of the membranes of the first twin at 19 weeks of gestation. She had one delivery with Caesarean section 16 years ago. In consultation with the patient induction of labor was done with delivery of the first twin, a death male fetus. After that, antibiotics and tocolytic therapy were administrated and the patient remained in the hospital about one week. The patient was discharged at home with regular control of her condition and condition of the fetus. The patient was again hospitalized at 33 weeks of gestation with uterine contractions on cardiotocography. After administration of corticosteroid therapy for fetal lung maturation she delivered spontaneously the second twin in a good condition and she was discharged from hospital after 16 days. In twin pregnancies clinicians must think about delayed interval delivery of the second twin, after delivery of the first twin, with an aim to increase chances for survival, especially for pregnancies less than 30 weeks of gestation.ΠΠ»ΠΈΠ·Π½Π°ΡΠΊΠΈΡΠ΅ Π±ΡΠ΅ΠΌΠ΅Π½ΠΎΡΡΠΈ ΡΠ΅ Π²ΠΈΡΠΎΠΊΠΎΡΠΈΠ·ΠΈΡΠ½ΠΈ Π±ΡΠ΅ΠΌΠ΅Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠ΄ΡΡΠΆΠ΅Π½ΠΈ ΡΠΎ ΠΌΠ½ΠΎΠ³ΡΠ±ΡΠΎΡΠ½ΠΈ ΠΊΠΎΠΌΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ, ΠΊΠ°ΠΊΠΎ: ΡΠΏΠΎΠ½ΡΠ°Π½ Π°Π±ΠΎΡΡΡΡ, ΠΏΡΠ΅Π΄Π²ΡΠ΅ΠΌΠ΅Π½ΠΎ ΠΏΡΡΠΊΠ°ΡΠ΅ Π½Π° ΠΏΠ»ΠΎΠ΄ΠΎΠ²ΠΈΡΠ΅ ΠΎΠ±Π²ΠΈΠ²ΠΊΠΈ, ΠΏΡΠ΅Π΄Π²ΡΠ΅ΠΌΠ΅Π½ΠΎ ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅, ΠΈΠ½ΡΡΠ°ΡΡΠ΅ΡΠΈΠ½Π° ΡΠΌΡΡ Π½Π° Π΅Π΄Π½ΠΈΠΎΡ ΠΈΠ»ΠΈ Π΄Π²Π°ΡΠ° Π±Π»ΠΈΠ·Π½Π°ΠΊΠ° ΠΈ Π΄Ρ. ΠΠ΅ ΠΏΠΎΡΡΠΎΠΈ ΠΊΠΎΠ½ΡΠ΅Π½Π·ΡΡ ΠΊΠ°ΠΊΠΎ Π΄Π° ΡΠ΅ ΠΏΠΎΡΡΠ°ΠΏΡΠ²Π° ΠΊΠ°Ρ Π±Π»ΠΈΠ·Π½Π°ΡΠΊΠΈ Π±ΡΠ΅ΠΌΠ΅Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠ»ΠΈΡΠΈΡΠ°Π½ΠΈ ΡΠΎ ΠΏΡΠ΅Π΄Π²ΡΠ΅ΠΌΠ΅Π½ΠΎ ΠΏΡΡΠΊΠ°ΡΠ΅ Π½Π° ΠΏΠ»ΠΎΠ΄ΠΎΠ²ΠΈΡΠ΅ ΠΎΠ±Π²ΠΈΠ²ΠΊΠΈ Π½Π° Π΅Π΄Π½ΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ ΠΈ ΡΠΈΠ·ΠΈΠΊ ΠΎΠ΄ ΠΏΡΠ΅Π΄Π²ΡΠ΅ΠΌΠ΅Π½ΠΎ ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅. ΠΠ²ΠΈΠ΅ ΡΠ»ΡΡΠ°ΠΈ ΡΠ΅ ΡΠ΅ΡΠΊΠΈ Π²ΠΎ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ°ΡΠ°. ΠΠΈΠ΅ ΠΏΡΠ΅Π·Π΅Π½ΡΠΈΡΠ°ΠΌΠ΅ ΡΠ»ΡΡΠ°Ρ Π½Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ° Π½Π° 35 Π³ΠΎΠ΄ΠΈΡΠ½Π° Π²ΠΎΠ·ΡΠ°ΡΡ, Ρ
ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠ°Π½Π° Π²ΠΎ ΡΡΡΠ°Π½ΠΎΠ²Π° ΠΎΠ΄ ΡΠ΅ΡΡΠΈΠ΅ΡΠ½ΠΎ Π½ΠΈΠ²ΠΎ, Π·Π°ΡΠ°Π΄ΠΈ Π±ΠΈΠ°ΠΌΠ½ΠΈΡΠ°Π»Π½Π° Π±ΠΈΡ
ΠΎΡΠΈΡΠ°Π»Π½Π° Π±Π»ΠΈΠ·Π½Π°ΡΠΊΠ° Π±ΡΠ΅ΠΌΠ΅Π½ΠΎΡΡ ΠΊΠΎΠΌΠΏΠ»ΠΈΡΠΈΡΠ°Π½Π° ΡΠΎ ΠΏΡΠ΅Π΄Π²ΡΠ΅ΠΌΠ΅Π½ΠΎ ΠΏΡΡΠΊΠ°ΡΠ΅ Π½Π° Π²ΠΎΠ΄Π΅Π½ΠΈΠΊΠΎΡ Π½Π° ΠΏΡΠ²ΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ Π²ΠΎ 19-ΡΠ° Π³Π΅ΡΡΠ°ΡΠΈΡΠΊΠ° Π½Π΅Π΄Π΅Π»Π°. ΠΡΠ΅Π΄ 16 Π³ΠΎΠ΄ΠΈΠ½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΡΠ° ΠΈΠΌΠ° Π΅Π΄Π½ΠΎ ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅ ΡΠΎ ΡΠ°ΡΡΠΊΠΈ ΡΠ΅Π·. ΠΠΎ ΠΊΠΎΠ½ΡΡΠ»ΡΠ°ΡΠΈΡΠ° ΡΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΡΠ° ΡΠ»Π΅Π΄Π΅ΡΠ΅ ΠΈΠ½Π΄ΡΠΊΡΠΈΡΠ° Π½Π° ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅ΡΠΎ ΡΠΎ ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅ Π½Π° ΠΏΡΠ²ΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ, ΠΌΡΡΠΎΠ² ΠΌΠ°ΡΠΊΠΈ ΠΏΠ»ΠΎΠ΄. ΠΠΎΡΠΎΠ° Π±Π΅ΡΠ΅ ΠΎΡΠ΄ΠΈΠ½ΠΈΡΠ°Π½Π° Π°Π½ΡΠΈΠ±ΠΈΠΎΡΡΠΊΠ° ΠΈ ΡΠΎΠΊΠΎΠ»ΠΈΡΠΈΡΠ½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡΠ° ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΡΠ° Π±Π΅ΡΠ΅ Π·Π°Π΄ΡΠΆΠ°Π½Π° Π²ΠΎ Π±ΠΎΠ»Π½ΠΈΡΠ° ΡΡΡΠ΅ Π΅Π΄Π½Π° Π½Π΅Π΄Π΅Π»Π°. ΠΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΡΠ° Π±Π΅ΡΠ΅ ΠΏΡΡΡΠ΅Π½Π° Π΄ΠΎΠΌΠ° ΡΠΎ ΡΠ΅Π΄ΠΎΠ²Π½ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈ Π½Π° Π½Π΅ΡΠ·ΠΈΠ½Π°ΡΠ° ΡΠΎΡΡΠΎΡΠ±Π° ΠΈ ΡΠΎΡΡΠΎΡΠ±Π°ΡΠ° Π½Π° ΠΏΠ»ΠΎΠ΄ΠΎΡ. ΠΠ°ΡΠΈΠ΅Π½ΡΠΊΠ°ΡΠ° Π±Π΅ΡΠ΅ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎ Ρ
ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠ°Π½Π° Π²ΠΎ 33-ΡΠ° Π³Π΅ΡΡΠ°ΡΠΈΡΠΊΠ° Π½Π΅Π΄Π΅Π»Π° ΡΠΎ ΡΡΠ΅ΡΠΈΠ½ΠΈ ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΠΈΠΈ Π½Π° ΠΊΠ°ΡΠ΄ΠΈΠΎΡΠΎΠΊΠΎΠ³ΡΠ°ΡΠΈΡΠ°. ΠΠΎ ΠΎΡΠ΄ΠΈΠ½ΠΈΡΠ°ΡΠ΅ Π½Π° ΠΊΠΎΡΡΠΈΠΊΠΎΡΡΠ΅ΡΠΎΠΈΠ΄Π½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡΠ° Π·Π° ΡΠ΅ΡΠ°Π»Π½ΠΎ Π±Π΅Π»ΠΎΠ΄ΡΠΎΠ±Π½ΠΎ Π·ΡΠ΅Π΅ΡΠ΅ ΡΠ°Π° ΡΠΏΠΎΠ½ΡΠ°Π½ΠΎ ΠΏΡΠ΅Π΄Π²ΡΠ΅ΠΌΠ΅Π½ΠΎ Π³ΠΎ ΠΏΠΎΡΠΎΠ΄ΠΈ Π²ΡΠΎΡΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ, Π²ΠΎ Π΄ΠΎΠ±ΡΠ° ΠΊΠΎΠ½Π΄ΠΈΡΠΈΡΠ° ΠΈ ΠΈΡΡΠΈΠΎΡ Π±Π΅ΡΠ΅ ΠΈΡΠΏΠΈΡΠ°Π½ ΠΎΠ΄ Π±ΠΎΠ»Π½ΠΈΡΠ° ΠΏΠΎ 16 Π΄Π΅Π½Π°. ΠΠ°Ρ Π±Π»ΠΈΠ·Π½Π°ΡΠΊΠΈΡΠ΅ Π±ΡΠ΅ΠΌΠ΅Π½ΠΎΡΡΠΈ Π΄ΠΎΠΊΡΠΎΡΠΈΡΠ΅ ΡΡΠ΅Π±Π° Π΄Π° ΡΠ°Π·ΠΌΠΈΡΠ»ΡΠ²Π°Π°Ρ Π·Π° ΠΎΠ΄Π»ΠΎΠΆΡΠ²Π°ΡΠ΅ Π½Π° ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»ΠΎΡ Π½Π° ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅ Π½Π° Π²ΡΠΎΡΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ, ΠΏΠΎ ΠΏΠΎΡΠΎΠ΄ΡΠ²Π°ΡΠ΅ΡΠΎ Π½Π° ΠΏΡΠ²ΠΈΠΎΡ Π±Π»ΠΈΠ·Π½Π°ΠΊ, ΡΠΎ ΡΠ΅Π» Π΄Π° ΠΌΡ Π³ΠΈ Π·Π³ΠΎΠ»Π΅ΠΌΠ°Ρ ΡΠ°Π½ΡΠΈΡΠ΅ Π·Π° ΠΏΡΠ΅ΠΆΠΈΠ²ΡΠ²Π°ΡΠ΅, ΠΎΡΠΎΠ±Π΅Π½ΠΎ Π·Π° Π±ΡΠ΅ΠΌΠ΅Π½ΠΎΡΡΠΈΡΠ΅ ΠΏΠΎΠΌΠ°Π»ΠΈ ΠΎΠ΄ 30-ΡΠ° Π³Π΅ΡΡΠ°ΡΠΈΡΠΊΠ° Π½Π΅Π΄Π΅Π»Π°. 
Androgen Secreting Steroid Cell Tumor of the Ovary Represented with Postmenopasal Bleeding and Extensive Hirsutism
Introduction: Steroid cell tumors of the ovary present less than 0.1% of all ovarian tumors and belong in the group of sex cord-stromal tumors.Case description: We present a case of 69-year-old woman investigated because of postmenopausal bleeding, a 5-year history of excessive hirsutism, baldness and acne. The evaluation revealed elevated serum testosterone, but ultrasound detected a 2 cm-mass of the left ovary. The patient underwent hysterectomy and bilateral adnexectomy. The histopathology diagnosis was steroid cell tumor, not otherwise specified. Postoperative chemotherapy was administered at the discretion of the radio-oncologist. At the last follow-up 48 months after surgery, the hirsutism was completely resolved, the serum testosterone was within the normal range and there was no evidence of recurrence.Conclusion: In adult patients with hirsutism and elevated serum testosterone a possibility of a presence of an ovarian steroid cell tumor should be considered. Surgery is the main treatment of such patients
Indicators of Preeclampsia in Correlation with Maternal Cytokines in Pregnancy
Aim: the purpose of the actual study was to evaluate, in the third trimester of pregnancy, the relationship between the formation of anti-inflammatory IL-10 cytokine and several indicators of moderate and severe preeclampsia. Materials and methods: in the third trimester of gestation, examination of the biochemical markers of preeclampsia (PE) and maternal IL-10 levels was conducted in 100 women with pregnancies complicated by varying degrees of preeclampsia and in 100 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Patients with preeclampsia were categorized into moderate and severe preeclampsia groups according to the degree of preeclampsia. Logistic regression of the different parameters for the occurrence of severe preeclampsia analysis was used to determine the predictive value. Results: the regression analysis detected systolic blood pressure of 160Β mmHg or higher, diastolic blood pressure of 100Β mmHg or higher, persistent proteinuria in pregnancy, serum LDH concentration of 450Β U/L or higher, and reduced serum concentrations of IL-10 as significant predictors of severe preeclampsia. Conclusion: significantly, lower IL-10 concentrations in maternal serum in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe form of preeclampsia
Π£Π»ΠΎΠ³Π°ΡΠ° Π½Π° Π½Π΅ΠΊΠΎΠΈ ΠΈΠ½ΡΠ»Π°ΠΌΠ°ΡΠΎΡΠ½ΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΈ, ΡΠΈΡΠΎΠΊΠΈΠ½ΠΈ ΠΈ ΡΡΠΌΠΎΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΈ Π²ΠΎ Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π° Π½Π° Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ°
Endometriosis is a multifactorial disease which etiopathogenesis has not been elucidated. One of the theories of etiopathogenesis is the inflammatory theory. Aims of the study: To develop a practical non-invasive test for the diagnosis of endometriosis by examining some inflammatory markers and cytokines; to compare the highly sensitive C-reactive protein (hsCRP), cytokines (interleukin-6-IL-6 and tumor necrotizing factor alpha) and the tumor marker cancer antigen 125 (CA-125) among healthy patients and patients with endometriosis; to determine the sensitivity and specificity of each biomarker separately in the diagnosis of endometriosis and to determine their role in the diagnosis of endometriosis. Materials and methods: In a prospective study conducted at the University Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University in Skopje, North Macedonia 138 patients were included of a reproductive age between 18-50 years (83 with diagnosis endometriosis operated laparoscopically or with laparotomy) and a control group of 55 healthy women, in a period between 01.09.2018 to 01.05.2021. Serum levels of IL-6, TNF-Ξ±, hs-CRP and tumor marker CA-125 were evaluated in both groups. Results: Serum levels of CA-125, IL-6 and TNF-Ξ± and hs-CRP were significantly higher in patients with endometriosis compared to the control group. The surface under the ROC curve (AUC) for IL-6, CA-125, hs-CRP, and TNF-Ξ± has shown that as individual markers they all have a discriminatory capacity to diagnose patients with endometriosis. Conclusions: Results obtained in our study showed statistically significantly higher serum concentrations of CA-125, IL-6 and TNF-Ξ± and hs-CRP in patients with endometriosis compared to the control group of patients. However, none of these biomarkers showed a high sensitivity for diagnosis of endometriosis. It is necessary to find a panel combination of biomarkers with a high sensitivity of about 100% that will enable early diagnosis of endometriosis.ΠΠ½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ° Π΅ ΠΌΡΠ»ΡΠΈΡΠ°ΠΊΡΠΎΡΠ½ΠΎ Π·Π°Π±ΠΎΠ»ΡΠ²Π°ΡΠ΅, ΡΠΈΡΠ° Π΅ΡΠΈΠΎΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° Π½Π΅ Π΅ ΡΠ°Π·ΡΠ°ΡΠ½Π΅ΡΠ°. ΠΠ΄Π½Π° ΠΎΠ΄ ΡΠ΅ΠΎΡΠΈΠΈΡΠ΅ Π·Π° Π΅ΡΠΈΠΎΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π°ΡΠ° Π΅ ΠΈΠ½ΡΠ»Π°ΠΌΠ°ΡΠΎΡΠ½Π°ΡΠ° ΡΠ΅ΠΎΡΠΈΡΠ°. Π¦Π΅Π»ΠΈ Π½Π° ΠΈΡΡΡΠ°ΠΆΡΠ²Π°ΡΠ΅ΡΠΎ: ΠΠ° ΡΠ΅ ΡΠ°Π·Π²ΠΈΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅Π½ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π΅Π½ ΡΠ΅ΡΡ Π·Π° Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π° Π½Π° Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ° ΡΠΎ ΠΈΡΠ»Π΅Π΄ΡΠ²Π°ΡΠ΅ Π½Π°Π½Π΅ΠΊΠΎΠΈ ΠΈΠ½ΡΠ»Π°ΠΌΠ°ΡΠΎΡΠ½ΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΈ ΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΈ; Π΄Π° ΡΠ΅ Π½Π°ΠΏΡΠ°Π²ΠΈ ΡΠΏΠΎΡΠ΅Π΄Π±Π° Π½Π° Π²ΠΈΡΠΎΠΊΠΎΡΠ΅Π½Π·ΠΈΡΠΈΠ²Π½ΠΈΠΎΡ Π¦-ΡΠ΅Π°ΠΊΡΠΈΠ²Π΅Π½ ΠΏΡΠΎΡΠ΅ΠΈΠ½ (hsCRP), ΡΠΈΡΠΎΠΊΠΈΠ½ΠΈΡΠ΅ (ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΡΠΊΠΈΠ½ 6 βIL-6 ΠΈ ΡΡΠΌΠΎΡ-Π½Π΅ΠΊΡΠΎΡΠΈΠ·ΠΈΡΠ°ΡΠΊΠΈ ΡΠ°ΠΊΡΠΎΡ Π°Π»ΡΠ° - TNF-Ξ±) ΠΈ ΡΡΠΌΠΎΡΡΠΊΠΈΠΎΡ ΠΌΠ°ΡΠΊΠ΅Ρ cancer antigen 125 (CA-125) ΠΊΠ°Ρ Π·Π΄ΡΠ°Π²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ ΡΠΎ Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°; Π΄Π° ΡΠ΅ ΡΡΠ²ΡΠ΄ΠΈ ΡΠ΅Π½Π·ΠΈΡΠΈΠ²Π½ΠΎΡΡΠ° ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠ° Π½Π° ΡΠ΅ΠΊΠΎΡ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅Ρ ΠΏΠΎΡΠ΅Π±Π½ΠΎ Π²ΠΎ Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π°ΡΠ° Π½Π° Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ° ΠΈ Π΄Π° ΡΠ΅ ΡΡΠ²ΡΠ΄ΠΈ Π½ΠΈΠ²Π½Π°ΡΠ° ΡΠ»ΠΎΠ³Π° Π²ΠΎ Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π° Π½Π° Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ°.
ΠΠ°ΡΠ΅ΡΠΈΡΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈ: ΠΠΎ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½Π° ΡΡΡΠ΄ΠΈΡΠ° ΡΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π½Π° Π£Π½ΠΈΠ²Π΅ΡΠ·ΠΈΡΠ΅ΡΡΠΊΠ°ΡΠ° ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ° Π·Π° Π³ΠΈΠ½Π΅ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ° ΠΈ Π°ΠΊΡΡΠ΅ΡΡΡΠ²ΠΎ, Π£Π½ΠΈΠ²Π΅ΡΠ·ΠΈΡΠ΅Ρ βΠ‘Π². ΠΠΈΡΠΈΠ» ΠΈ ΠΠ΅ΡΠΎΠ΄ΠΈΡβ Π²ΠΎ Π‘ΠΊΠΎΠΏΡΠ΅, Π‘Π΅Π²Π΅ΡΠ½Π° ΠΠ°ΠΊΠ΅Π΄ΠΎΠ½ΠΈΡΠ° Π±Π΅Π° Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈ 138 ΠΈΡΠΏΠΈΡΠ°Π½ΠΈΡΠΊΠΈ Π½Π° ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½Π° Π²ΠΎΠ·ΡΠ°ΡΡ ΠΏΠΎΠΌΠ΅ΡΡ 18-50 Π³ΠΎΠ΄ΠΈΠ½ΠΈ (83 ΡΠΎ Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·a Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°, ΠΎΠΏΠ΅ΡΠΈΡΠ°Π½ΠΈ ΡΠΎ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡΠ° ΠΈΠ»ΠΈ Π»Π°ΠΏΠ°ΡΠΎΡΠΎΠΌΠΈΡΠ°) ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Π½Π° Π³ΡΡΠΏΠ° ΠΎΠ΄ 55 Π·Π΄ΡΠ°Π²ΠΈ ΠΆΠ΅Π½ΠΈ, Π²ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΎΠ΄ 01.09.2018 Π³ΠΎΠ΄ΠΈΠ½Π° Π΄ΠΎ 01.05.2021. Π‘Π΅ΡΡΠΌΡΠΊΠΈΡΠ΅ Π²ΡΠ΅Π΄Π½ΠΎΡΡΠΈ Π½Π° ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΡΠΊΠΈΠ½ 6 (IL-6), ΡΡΠΌΠΎΡ-Π½Π΅ΠΊΡΠΎΡΠΈΠ·ΠΈΡΠ°ΡΠΊΠΈ ΡΠ°ΠΊΡΠΎΡ Π°Π»ΡΠ° (TNF-Ξ±), Π²ΠΈΡΠΎΠΊΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅Π½ Π¦-ΡΠ΅Π°ΠΊΡΠΈΠ²Π΅Π½ ΠΏΡΠΎΡΠ΅ΠΈΠ½ (hsCRP) ΠΈ ΡΡΠΌΠΎΡΡΠΊΠΈΠΎΡ ΠΌΠ°ΡΠΊΠ΅Ρ CA-125 Π±Π΅Π° Π΅Π²Π°Π»ΡΠΈΡΠ°Π½ΠΈ Π²ΠΎ Π΄Π²Π΅ΡΠ΅ Π³ΡΡΠΏΠΈ. Π Π΅Π·ΡΠ»ΡΠ°ΡΠΈ: Π‘Π΅ΡΡΠΌΡΠΊΠΈΡΠ΅ Π²ΡΠ΅Π΄Π½ΠΎΡΡΠΈ Π½Π° CA-125, IL-6 ΠΈ TNF-Ξ± ΠΈ hsCRP Π±Π΅Π° ΡΠΈΠ³Π½ΠΈΡΠΈΠΊΠ°Π½ΡΠ½ΠΎ ΠΏΠΎΠ²ΠΈΡΠΎΠΊΠΈ ΠΊΠ°Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈΡΠ΅ ΡΠΎ Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π° Π²ΠΎ ΡΠΏΠΎΡΠ΅Π΄Π±Π° ΡΠΎ ΠΎΠ½ΠΈΠ΅ Π²ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Π½Π°ΡΠ° Π³ΡΡΠΏΠ°. ΠΠΎΠ²ΡΡΠΈΠ½Π°ΡΠ° ΠΏΠΎΠ΄ ROC ΠΊΡΠΈΠ²Π°ΡΠ° (AUC) Π·Π° IL-6, CA-125, hs-CRP ΠΈ TNF-Ξ± ΠΏΠΎΠΊΠ°ΠΆΠ° Π΄Π΅ΠΊΠ° ΠΊΠ°ΠΊΠΎ ΠΏΠΎΠ΅Π΄ΠΈΠ½Π΅ΡΠ½ΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΈ ΡΠΈΡΠ΅ ΠΈΠΌΠ°Π°Ρ Π΄ΠΈΡΠΊΡΠΈΠΌΠΈΠ½Π°ΡΠΎΡΠ΅Π½ ΠΊΠ°ΠΏΠ°ΡΠΈΡΠ΅Ρ Π·Π° Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π° Π½Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ ΡΠΎ Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°. ΠΠ°ΠΊΠ»ΡΡΠΎΡΠΈ: ΠΡΠ»Π΅Π΄ΡΠ²Π°ΡΠ°ΡΠ° Π²ΠΎ Π½Π°ΡΠ°ΡΠ° ΡΡΡΠ΄ΠΈΡΠ° ΠΏΠΎΠΊΠ°ΠΆΠ°Π° ΡΡΠ°ΡΠΈΡΡΠΈΡΠΊΠΈ ΡΠΈΠ³Π½ΠΈΡΠΈΠΊΠ°Π½ΡΠ½ΠΎ ΠΏΠΎΠ²ΠΈΡΠΎΠΊΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π½Π° CA-125, IL-6 ΠΈ TNF-Ξ± ΠΈ hs-CRP ΠΊΠ°Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈΡΠ΅ ΡΠΎ Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π° Π²ΠΎ ΠΎΠ΄Π½ΠΎΡ Π½Π° ΠΊΠΎΠ½ΡΡΠΎΠ»Π½Π°ΡΠ° Π³ΡΡΠΏΠ° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ. ΠΠ΅ΡΡΡΠΎΠ°, Π½ΠΈΡΡ Π΅Π΄Π΅Π½ ΠΎΠ΄ ΠΎΠ²ΠΈΠ΅ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΈ Π½Π΅ ΠΏΠΎΠΊΠ°ΠΆΠ° Π²ΠΈΡΠΎΠΊΠ° ΡΠ΅Π½Π·ΠΈΡΠΈΠ²Π½ΠΎΡΡ Π·Π° Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π° Π½Π° Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ°. ΠΠΎΡΡΠ΅Π±Π½ΠΎ Π΅ Π΄Π° ΡΠ΅ Π½Π°ΡΠ΄Π΅ ΠΏΠ°Π½Π΅Π» ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΡΠ° Π½Π° Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΈ ΡΠΎ Π²ΠΈΡΠΎΠΊΠ° ΡΠ΅Π½Π·ΠΈΡΠΈΠ²Π½ΠΎΡΡ ΠΎΠ΄ ΠΎΠΊΠΎΠ»Ρ 100% ΠΊΠΎΠΈ ΡΠ΅ ΠΎΠ²ΠΎΠ·ΠΌΠΎΠΆΠ°Ρ ΡΠ°Π½Π° Π΄ΠΈΡΠ°Π³Π½ΠΎΠ·Π° Π½Π° Π΅Π½Π΄ΠΎΠΌΠ΅ΡΡΠΈΠΎΠ·Π°ΡΠ°