Effect of rosiglitazone and pioglitazone treatment on histological grading of ankle lesions during adjuvant-induced arthritis

Animals were treated daily for 21 days with rosiglitazone (ROSI) 10 mg/kg (= 8) or pioglitazone (PIO) 30 mg/kg (= 8) by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) (= 7) and normal controls (= 7) were given 0.5% carboxymethylcellulose alone. Cartilage degradation and bone erosion were graded as indicated in the Materials and methods section. Data are expressed as means ± SEM for five representative animals per group. *, < 0.05 compared with normal controls; , < 0.05 compared with AIA controls (Mann–Whitney test).<p><b>Copyright information:</b></p><p>Taken from "Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis"</p><p>Arthritis Research & Therapy 2008;10(1):R6-R6.</p><p>Published online 16 Jan 2008</p><p>PMCID:PMC2374462.</p><p></p

Effect of rosiglitazone and pioglitazone treatment on expression of PPAR target genes during adjuvant-induced arthritis

Animals were treated daily for 21 days with rosiglitazone (ROSI) 10 mg/kg or pioglitazone (PIO) 30 mg/kg by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) and normal controls were given 0.5% carboxymethylcellulose alone. mRNA levels of adiponectin and peroxisome proliferator-activated receptor (PPAR)-γ normalized to RP29 in adipose tissue were assessed by RT-quantitative polymerase chain reaction. Data are expressed as means ± SEM for three representative samples per group (arthritis score close to the mean score of the group). , < 0.05 compared with AIA controls (ANOVA and Fisher's PLSD post-hoc test).<p><b>Copyright information:</b></p><p>Taken from "Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis"</p><p>Arthritis Research & Therapy 2008;10(1):R6-R6.</p><p>Published online 16 Jan 2008</p><p>PMCID:PMC2374462.</p><p></p

DataSheet1_The 10th Santorini conference: Systems medicine, personalised health and therapy. “The odyssey from hope to practice: Patient first. Keep Ithaca always in your mind”, Santorini, Greece, 23–26 May 2022.DOCX

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