Animals were treated daily for 21 days with rosiglitazone (ROSI) 10 mg/kg or pioglitazone (PIO) 30 mg/kg by oral administration. Arthritic (adjuvant-induced arthritis (AIA)) and normal controls were given 0.5% carboxymethylcellulose alone. mRNA levels of adiponectin and peroxisome proliferator-activated receptor (PPAR)-γ normalized to RP29 in adipose tissue were assessed by RT-quantitative polymerase chain reaction. Data are expressed as means ± SEM for three representative samples per group (arthritis score close to the mean score of the group). , < 0.05 compared with AIA controls (ANOVA and Fisher's PLSD post-hoc test).<p><b>Copyright information:</b></p><p>Taken from "Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis"</p><p>Arthritis Research & Therapy 2008;10(1):R6-R6.</p><p>Published online 16 Jan 2008</p><p>PMCID:PMC2374462.</p><p></p
