Where Epigenetics Meets Food Intake: Their Interaction in the Development/Severity of Gout and Therapeutic Perspectives

Gout is the most frequent form of inflammatory arthritis in the world. Its prevalence is particularly elevated in specific geographical areas such as in the Oceania/Pacific region and is rising in the US, Europe, and Asia. Gout is a severe and painful disease, in which co-morbidities are responsible for a significant reduction in life expectancy. However, gout patients remain ostracized because the disease is still considered “self-inflicted”, as a result of unhealthy lifestyle and excessive food and alcohol intake. While the etiology of gout flares is clearly associated with the presence of monosodium urate (MSU) crystal deposits, several major questions remain unanswered, such as the relationships between diet, hyperuricemia and gout flares or the mechanisms by which urate induces inflammation. Recent advances have identified gene variants associated with gout incidence. Nevertheless, genetic origins of gout combined to diet-related possible uric acid overproduction account for the symptoms in only a minor portion of patients. Hence, additional factors must be at play. Here, we review the impact of epigenetic mechanisms in which nutrients (such as ω-3 polyunsaturated fatty acids) and/or dietary-derived metabolites (like urate) trigger anti/pro-inflammatory responses that may participate in gout pathogenesis and severity. We propose that simple dietary regimens may be beneficial to complement therapeutic management or contribute to the prevention of flares in gout patients

THE OPTIMIZATION OF THE INTERNAL AND EXTERNAL REPORTING IN FINANCIAL ACCOUNTING: ADOPTING XBRL INTERNATIONAL STANDARD

More and more enterprises, especially the listed companies, have adopted newaccounting norms and regulations (IFRS or US GAAP, Bale II and, in perspective, SURFI),manifesting interest for publishing financial reports using a standard format able to considerablyimprove their communication, data collection in the receiving units, control and analysis offinancial information. When switching to the new accounting rules specified in international orregional standards and norms, regulatory and control bodies recommend the XBRL format forfinancial reporting, with recognition of the regional jurisdiction. Our paper makes a review of theliterature, presents the XBRL specific elements and proposes possible solutions for internal andexternal financial reporting of an enterprise. Finally, it concludes on the benefits of adopting XBRLat national level in a potential XBRL Romania project.accounting norms, financial reporting, XBRL, taxonomy, XBRL jurisdiction.

A Theory of Partitioned Global Address Spaces

Partitioned global address space (PGAS) is a parallel programming model for the development of applications on clusters. It provides a global address space partitioned among the cluster nodes, and is supported in programming languages like C, C++, and Fortran by means of APIs. In this paper we provide a formal model for the semantics of single instruction, multiple data programs using PGAS APIs. Our model reflects the main features of popular real-world APIs such as SHMEM, ARMCI, GASNet, GPI, and GASPI. A key feature of PGAS is the support for one-sided communication: a node may directly read and write the memory located at a remote node, without explicit synchronization with the processes running on the remote side. One-sided communication increases performance by decoupling process synchronization from data transfer, but requires the programmer to reason about appropriate synchronizations between reads and writes. As a second contribution, we propose and investigate robustness, a criterion for correct synchronization of PGAS programs. Robustness corresponds to acyclicity of a suitable happens-before relation defined on PGAS computations. The requirement is finer than the classical data race freedom and rules out most false error reports. Our main result is an algorithm for checking robustness of PGAS programs. The algorithm makes use of two insights. Using combinatorial arguments we first show that, if a PGAS program is not robust, then there are computations in a certain normal form that violate happens-before acyclicity. Intuitively, normal-form computations delay remote accesses in an ordered way. We then devise an algorithm that checks for cyclic normal-form computations. Essentially, the algorithm is an emptiness check for a novel automaton model that accepts normal-form computations in streaming fashion. Altogether, we prove the robustness problem is PSpace-complete

EXTENDED ENTERPRISE AND INFORMATION SYSTEMS GOVERNANCE IN AN INTER-ORGANIZATIONAL CONTEXT

Flexibility, openness, and cooperation are fundamental tendencies that positively mark the ensemble of private and public sector organizations. For a sustainable development in a more and more complex globalized and competitive business environment, the ee-business, extended enterprise, inter-enterprise cooperative information systems, workflow, corporate governance, IS governance