Towards improved performance and interoperability in distributed and physical union catalogues

Purpose of this paper: This paper details research undertaken to determine the key differences in the performance of certain centralised (physical) and distributed (virtual) bibliographic catalogue services, and to suggest strategies for improving interoperability and performance in, and between, physical and virtual models. Design/methodology/approach: Methodically defined searches of a centralised catalogue service and selected distributed catalogues were conducted using the Z39.50 information retrieval protocol, allowing search types to be semantically defined. The methodology also entailed the use of two workshops comprising systems librarians and cataloguers to inform suggested strategies for improving performance and interoperability within both environments. Findings: Technical interoperability was permitted easily between centralised and distributed models, however the various individual configurations permitted only limited semantic interoperability. Significant prescription in cataloguing and indexing guidelines, greater participation in the Program for Collaborative Cataloging (PCC), consideration of future 'FRBR' migration, and greater disclosure to end users are some of the suggested strategies to improve performance and semantic interoperability. Practical implications: This paper informs the LIS research community and union catalogue administrators, but also has numerous practical implications for those establishing distributed systems based on Z39.50 and SRW, as well as those establishing centralised systems. What is original/value of the paper?: The paper moves the discussion of Z39.50 based systems away from anecdotal evidence and provides recommendations based on testing and is intimately informed by the UK cataloguing and systems librarian community

Developmental potential of trunk neural crest cells in the mouse

The availability of naturally occurring and engineered mutations in mice which affect the neural crest makes the mouse embryo an important experimental system for studying neural crest cell differentiation. Here, we determine the normal developmental potential of neural crest cells by performing in situ cell lineage analysis in the mouse by microinjecting lysinated rhodamine dextran (LRD) into individual dorsal neural tube cells in the trunk. Labeled progeny derived from single cells were found in the neural tube, dorsal root ganglia, sympathoadrenal derivatives, presumptive Schwann cells and/or pigment cells. Most embryos contained labeled cells both in the neural tube and at least one neural crest derivative, and numerous clones contributed to multiple neural crest derivatives. The time of injection influenced the derivatives populated by the labeled cells. Injections at early stages of migration yielded labeled progeny in both dorsal and ventral neural crest derivatives, whereas those performed at later stages had labeled cells only in more dorsal neural crest derivatives, such as dorsal root ganglion and presumptive pigment cells. The results suggest that in the mouse embryo: (1) there is a common precursor for neural crest and neural tube cells; (2) some neural crest cells are multipotent; and (3) the timing of emigration influences the range of possible neural crest derivatives

A vital dye analysis of the timing and pathways of avian trunk neural crest cell migration

To permit a more detailed analysis of neural crest cell migratory pathways in the chick embryo, neural crest cells were labelled with a nondeleterious membrane intercalating vital dye, DiI. All neural tube cells with endfeet in contact with the lumen, including premigratory neural crest cells, were labelled by pressure injecting a solution of DiI into the lumen of the neural tube. When assayed one to three days later, migrating neural crest cells, motor axons, and ventral root cells were the only cells types external to the neural tube labelled with DiI. During the neural crest cell migratory phase, distinctly labelled cells were found along: (1) a dorsolateral pathway, under the epidermis, as well adjacent to and intercalating through the dermamyotome; and (2) a ventral pathway, through the rostral portion of each sclerotome and around the dorsal aorta as described previously. In contrast to those cells migrating through the sclerotome, labelled cells on the dorsolateral pathway were not segmentally arranged along the rostrocaudal axis. DiI-labelled cells were observed in all truncal neural crest derivatives, including subepidermal presumptive pigment cells, dorsal root ganglia, and sympathetic ganglia. By varying the stage at which the injection was performed, neural crest cell emigration at the level of the wing bud was shown to occur from stage 13 through stage 22. In addition, neural crest cells were found to populate their derivatives in a ventral-to-dorsal order, with the latest emigrating cells migrating exclusively along the dorsolateral pathway

Pathways of trunk neural crest cell migration in the mouse embryo as revealed by vital dye labelling

Analysis of neural crest cell migration in the mouse has been difficult due to the lack of reliable cell markers. Recently, we found that injection of DiI into the chick neural tube marks premigratory neural crest cells whose endfeet are in contact with the lumen of the neural tube (Serbedzija et al. Development 106, 809–819 (1989)). In the present study, this technique was applied to study neural crest cell migratory pathways in the trunk of the mouse embryo. Embryos were removed from the mother between the 8th and the 10th days of development and DiI was injected into the lumen of the neural tube. The embryos were then cultured for 12 to 24 h, and analyzed at the level of the forelimb. We observed two predominant pathways of neural crest cell migration: (1) a ventral pathway through the rostral portion of the somite and (2) a dorsolateral pathway between the dermamyotome and the epidermis. Neural crest cells were observed along the dorsolateral pathway throughout the period of migration. The distribution of labelled cells along the ventral pathway suggested that there were two overlapping phases of migration. An early ventrolateral phase began before E9 and ended by E9.5; this pathway consisted of a stream of cells within the rostral sclerotome, adjacent to the dermamyotome, that extended ventrally to the region of the sympathetic ganglia and the dorsal aorta

Vital dye labelling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos

We have used the vital dye, DiI, to analyze the contribution of sacral neural crest cells to the enteric nervous system in chick and mouse embryos. In order to label premigratory sacral neural crest cells selectively, DiI was injected into the lumen of the neural tube at the level of the hindlimb. In chick embryos, DiI injections made prior to stage 19 resulted in labelled cells in the gut, which had emerged from the neural tube adjacent to somites 29–37. In mouse embryos, neural crest cells emigrated from the sacral neural tube between E9 and E9.5. In both chick and mouse embryos, DiI-labelled cells were observed in the rostral half of the somitic sclerotome, around the dorsal aorta, in the mesentery surrounding the gut, as well as within the epithelium of the gut. Mouse embryos, however, contained consistently fewer labelled cells than chick embryos. DiI-labelled cells first were observed in the rostral and dorsal portion of the gut. Paralleling the maturation of the embryo, there was a rostral-to-caudal sequence in which neural crest cells populated the gut at the sacral level. In addition, neural crest cells appeared within the gut in a dorsal-to-ventral sequence, suggesting that the cells entered the gut dorsally and moved progressively ventrally. The present results resolve a long-standing discrepancy in the literature by demonstrating that sacral neural crest cells in both the chick and mouse contribute to the enteric nervous system in the postumbilical gut

Input usage, output mix and industry deregulation: an analysis of the Australian dairy manufacturing industry

In this paper we estimate a Translog output distance function for a balanced panel of state level data for the Australian dairy processing sector. We estimate a fixed effects specification employing Bayesian methods, with and without the imposition of monotonicity and curvature restrictions. Our results indicate that Tasmania and Victoria are the most technically efficient states with New South Wales being the least efficient. The imposition of theoretical restrictions marginally affects the results especially with respect to estimates of technical change and industry deregulation. Importantly, our bias estimates show changes in both input use and output mix that result from deregulation. Specifically, we find that deregulation has positively biased the production of butter, cheese and powders.Bayesian, deregulation, output distance function, Agribusiness,

Paper Session II-A - Space Station Assured Crew Return Vehicle (ACRV) System and Operational Considerations

The Space Station currently is being designed to maximize crew safety through fault tolerance, safehaven provisions, and crew delivery and return using the Space Transportation System (STS). Studies have identified the need for assured crew return capability through a space-based lifeboat that is always available for use in contingencies encompassing (1) medical emergencies, (2) Space Station failures, and (3) interruption of STS services. This paper reviews major mission, operational, and system requirements and the process for evaluating a range of practical vehicle and operational options. It describes flight and ground system design concepts and the major trade studies being performed to select the best end-to-end system that will provide a basis for design and development. Flight vehicles include capsules with ballistic and low lift/drag characteristics and lifting body aerodynamic-shaped designs. Ground systems emphasize the use of existing resources

Bills of Peace Revisited

At common law it was usually impossible to litigate separate claims at one time even though the claims involved common issues. On the other hand, the equity court recognized that a multiplicity of suits should be avoided where there was a relationship between the claims. Therefore, a bill of peace to prevent separate trials would lie where a number of related claims were being asserted against a defendant. Unfortunately, the cases in this country have not agreed as to the nature of the relationship that must exist between the claims. Some cases, adopting the view of Professor Pomeroy,2 have held that a bill of peace will lie where the claims involve only common questions of law and fact. Other cases hold that the existence of common questions of law and fact is not enough although they do not agree as to what is necessary. The leading case for this view, which is probably the majority view, is Tribette v. Illinois Central Railroad. However, recent decisions and procedural changes indicate that the Tribette case should no longer be followed and that courts have the power to join claims that involve only common questions of law and fact to reduce the time and expense of litigation