Recent trends in US patent grants and issues to be considered

The life sciences have changed radically since the Convention on Biological Diversity first opened for signatures in 1992. Traditional organism-based approaches to discovery and use of genetic resources have been supplanted by molecular approaches. Biodiversity prospecting is more likely to be a programmatic bioinformatics activity rather than an activity conducted by field scientists. Access to genetic resources is no longer centered on a hunt for novel species. Rather, the hunt is for novel genes and metabolic pathways that can be cloned into well-understood expression systems and readily scaled-up for industrial production. Information about contemporary research, development, and manufacturing practices needs to be addressed, especially when those genes do not need to be associated with their native host at the time of discovery. Information about the research organizations participating in all phases of the discovery and development process also needs to be considered, especially when it involves partnerships between academic and industrial organizations. 

We present a high-level view of recent trends in the issuance of US patent grants to commercial and non-commercial research organizations, and introduce a technology that is already in place which can be applied to monitoring the use of genetic materials by various stakeholders in an open and transparent manner, as intended under the International Regime for Access and Benefit Sharing (ABS).
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Documents relating to the Ursuline Convent in Charlestown

An 1842 reprint containing two reports detailing the events surrounding the 1834 mob destruction of the Ursuline Convent in Charlestown, MA. The first report discusses the public responsibility and duty of the State to protect its citizens and their property, regardless of social or religious affiliation, from unjust actions. The second report, produced by a select committee of the Massachusetts House of Representatives, discusses the merits of a petition for the Commonwealth to indemnify the Sisters of the Ursuline Order for their loss. Boston: Reprinted by Samuel N. Dickinson, 1842. See The Trial of John R. Buzzell by Lemuel Shaw, LL.D, published at the time of the incident (1834) for a detailed account of the mob destruction of the Convent and the subsequent trial of Buzzell and his fellow co-conspirators

Useful Descriptions of Organizational Processes: Collecting Data for the Process Handbook

This paper describes a data collection methodology for business process analysis. Unlike static objects, business processes are semi-repetitive sequences of events that are often widely distributed in time and space, with ambiguous boundaries. To redesign or even just describe a business process requires an approach that is sensitive to these aspects of the phenomena. The method described here is intended to generate semi-formal process representations suitable for inclusion in a "handbook" of organizational processes. Using basic techniques of ethnographic interviewing and observation, the method helps users map decomposition, specialization, and dependency relationships at an intermediate level of abstraction meaningful to participants. By connecting new process descriptions to an existing taxonomy of similar descriptions in the Handbook, this method helps build a common vocabulary for process description and analysis.

Teaching Aids, Quality Delivery, And Effective Learning Outcomes In A Nigerian Private University

Globally, Universities exist to teach, carry out research and engage in community service. As knowledge centers and major contributors to the manpower resources of the nation's economy, the place of teaching, effective learning and quality delivery should not be underestimated. One of the key performance indicators (KPI) for World University Ranking by the Times Higher Education is teaching. Although teaching involves a series of activities to enhance learning, past studies have shown that students or learners get easily bored with long lecture sessions and worse still retain less than 25 percent of what is taught. Thus, new skills, processes and information intended may not be maximized. There is a suspicion that Universities in most of Africa, including Nigeria may not have appealed to the senses of the students through a multi-modal approach including the use of teaching aids. This study intends to examine the role of teaching aids (gadgets, resources and materials) in enhancing effective teaching outcomes and quality delivery at Covenant University, a Nigerian Private University with a view to drawing some lessons. The study has identified the range of teaching aids and processes adopted by the University in her drive towards the fulfillment of a global mandate of becoming one of the first ten Universities in the world. The study adopts the social learning theory and survey design for data collection. Results from the questionnaire administered to selected teaching staff and students as well as interviews of key personnel of the University formed the basis for conclusions and recommendations in this study. It is intended that the wider sociological, and technological implications will be emphasized just as we position teaching as an aspect of strategic communicatio

Steady-state dynamic behavior of an auxiliary bearing supported rotor system

This paper investigates the steady-state responses of a rotor system supported by auxiliary bearings in which there is a clearance between the rotor and the inner race of the bearing. A simulation model based upon the rotor of a production jet engine is developed and its steady-state behavior is explored over a wide range of operating conditions for various parametric configurations. Specifically, the influence of rotor imbalance, support stiffness, and damping is studied. It is found that imbalance may change the rotor responses dramatically in terms of frequency contents at certain operating speeds. Subharmonic responses of 2nd order through 10th order are all observed except the 9th order. Chaotic phenomenon is also observed. Jump phenomena (or double-valued responses) of both hard-spring type and soft-spring type are shown to occur at low operating speeds for systems with low auxiliary bearing damping or large clearance even with relatively small imbalance. The effect of friction between the shaft and the inner race of the bearing is also discussed

The Spectral Energy Distribution of Dust Emission in the Edge-on spiral galaxy NGC 4631 as seen with Spitzer and the James Clerk Maxwell telescope

We explore variations in dust emission within the edge-on Sd spiral galaxy NGC 4631 using 3.6-160 μm Spitzer Space Telescope data and 450-850 μm JCMT data with the goals of understanding the relation between PAHs and dust emission, studying the variations in the colors of the dust emission, and searching for possible excess submillimeter emission compared to what is expected from dust models extrapolated from far-infrared wavelengths. The 8 μm PAH emission correlates best with 24 μm hot dust emission on 1.7 kpc scales, but the relation breaks down on 650 pc scales, possibly because of differences in the mean free paths between photons that excite the PAHs and photons that heat the dust and possibly because the PAHs are destroyed by the hard radiation fields within some star formation regions. The ratio of 8 μm PAH emission to 160 μm cool dust emission appears to vary as a function of radius. The 70 μm/160 μm and 160 μm/450 μm flux density ratios are remarkably constant even though the surface brightnesses vary by factors of 25, which suggests that the emission is from dust heated by a nearly uniform radiation field. Globally, we find an excess of 850-1230 μm emission relative to what would be predicted by dust models. The 850 μm excess is highest in regions with low 160 μm surface brightnesses, although the magnitude depends on the model fit to the data. We rule out variable emissivity functions or ~4 K dust as the possible origins of this 850 μm emission, but we do discuss the other possible mechanisms that could produce the emission

Gravity and Signature Change

The use of proper ``time'' to describe classical ``spacetimes'' which contain both Euclidean and Lorentzian regions permits the introduction of smooth (generalized) orthonormal frames. This remarkable fact permits one to describe both a variational treatment of Einstein's equations and distribution theory using straightforward generalizations of the standard treatments for constant signature.Comment: Plain TeX, 6 pages; to appear in GR

NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients

Objective: The purpose of this study was to determine the effects of prophylactic near-infrared light therapy from light-emitting diodes (LEDs) in pediatric bone marrow transplant (BMT) recipients. Background Data: Oral mucositis (OM) is a frequent side effect of chemotherapy that leads to increased morbidity. Near-infrared light has been shown to produce biostimulatory effects in tissues, and previous results using nearinfrared lasers have shown improvement in OM indices. However, LEDs may hold greater potential for clinical applications. Materials and Methods: We recruited 32 consecutive pediatric patients undergoing myeloablative therapy in preparation for BMT. Patients were examined by two of three pediatric dentists trained in assessing the Schubert oral mucositis index (OMI) for left and right buccal and lateral tongue mucosal surfaces, while the patients were asked to rate their current left and right mouth pain, left and right xerostomia, and throat pain. LED therapy consisted of daily treatment at a fluence of 4 J/cm2 using a 670-nm LED array held to the left extraoral epithelium starting on the day of transplant, with a concurrent sham treatment on the right. Patients were assessed before BMT and every 2–3 days through posttransplant day 14. Outcomes included the percentage of patients with ulcerative oral mucositis (UOM) compared to historical epidemiological controls, the comparison of left and right buccal pain to throat pain, and the comparison between sides of the buccal and lateral tongue OMI and buccal pain. Results: The incidence of UOM was 53%, compared to an expected rate of 70–90%. There was also a 48% and 39% reduction of treated left and right buccal pain, respectively, compared to untreated throat pain at about posttransplant day 7 (p \u3c 0.05). There were no significant differences between sides in OMI or pain. Conclusion: Although more studies are needed, LED therapy appears useful in the prevention of OM in pediatric BMT patients