6 research outputs found
The economics of debt clearing mechanisms
We examine the evolution of decentralized clearinghouse mechanisms from the
13th to the 18th century; in particular, we explore the clearing of non- or
limitedtradable debts like bills of exchange. We construct a theoretical model
of these clearinghouse mechanisms, similar to the models in the theoretical
matching literature, and show that specific decentralized multilateral
clearing algorithms known as rescontre, skontrieren or virement des parties
used by merchants were efficient in specific historical contexts. We can
explain both the evolutionary self-organizing emergence of late medieval and
early modern fairs, and its robustness during the 17th and 18th century
Entscheidungen des Hanseatischen Oberlandesgerichts in Strafsachen aus den Jahren 1879-1897
Das deutsche Seerecht : Kommentar zum vierten Buche des Handelsgesetzbuchs (als Ergänzung zu Staub's Kommentar) ; nebst Erläuterungen zu den seerechtlichen Nebengesetzen. Bd 1
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.The aim of this study was to inform vaccination prioritization by modelling the impact of vaccination on elective inpatient surgery. The study found that patients aged at least 70 years needing elective surgery should be prioritized alongside other high-risk groups during early vaccination programmes. Once vaccines are rolled out to younger populations, prioritizing surgical patients is advantageous