Off-label use of targeted therapies in osteosarcomas: data from the French registry OUTC'S (Observatoire de l'Utilisation des Thérapies Ciblées dans les Sarcomes):

BACKGROUND: The objective of this study is to explore the off-label use of targeted therapies (TTs) for patients with osteosarcoma registered within the French Sarcoma Group--Bone Tumor Study Group (GSF-GETO) national registry. METHODS: All patients with an osteosarcoma, registered between January 1, 2009 and July 15, 2013 were analyzed. RESULTS: Twenty-nine patients with refractory relapsed osteosarcomas received 33 treatment lines of TTs. The median age at the beginning of treatment was 19 years (range 9-72). The median number of previous lines of chemotherapy was 3 (range 1-8). Before inclusion, 3 patients were in second complete remission, 26 were in progression for metastatic relapse. Twenty-three patients received sirolimus (in combination with cyclophosphamide for 18); 5, sunitinib; 4, sorafenib; and one, pazopanib. Stable disease was observed for 45.5% of patients (95% Confidence Interval (CI) [20-52.8]). The median Progression-Free Survival (PFS) was 3 months (95% CI [2-5.4]) for patients treated by sirolimus and 1.8 months (95% CI [1.3-2.8]) for patients receiving multi-targeted tyrosine kinase inhibitors; 6-month PFS 15%. The median Overall Survival (OS) was 6.8 months (95% CI [4.7-12.1]), and one-year OS was 24%. In a multivariate analysis, PFS was superior for patients receiving sirolimus compared to other TTs (Hazard Ratio (HR) = 2.7, 95% CI [1.05-7.1]). No toxic death was reported. Grade 3 and 4 toxicities were observed in 27 and 6% of cases respectively. CONCLUSION: Off-label TTs, especially sirolimus, reported benefit in the treatment of refractory osteosarcomas with an acceptable toxicity profile, including in pediatric population

Holostereosynthesis: An Improvement to Louis Lumière’s Photostereosynthesis Technique

In 1920, Louis Lumière, one of the fathers of Cinématograph, invented photostereosynthesis, a photography technique that could recreate three-dimensional images without a specific artifice. This method involved stacking six to eight photographs of the same subject, usually a portrait, recorded with a progressive shift in focus and observed together through transparency. This invention remained at the laboratory experiment stage, and only a dozen portraits of famous people from the time of Lumière are known. The final device is a complex assembly of glass plates mounted on a wooden frame, and it is fragile, bulky, heavy, and difficult to build and observe. Here, we demonstrate that we can replace the stack of photographic plates with a single reflection hologram. Experiments were successfully conducted using the digital CHIMERA holographic stereogram printing technique. This new method of holostereosynthesis will facilitate the restoration and dissemination of the historical portraits originally recorded by Louis Lumière and may also allow the creation of brand new images

Holostereosynthesis: An Improvement to Louis Lumière’s Photostereosynthesis Technique

In 1920, Louis Lumière, one of the fathers of Cinématograph, invented photostereosynthesis, a photography technique that could recreate three-dimensional images without a specific artifice. This method involved stacking six to eight photographs of the same subject, usually a portrait, recorded with a progressive shift in focus and observed together through transparency. This invention remained at the laboratory experiment stage, and only a dozen portraits of famous people from the time of Lumière are known. The final device is a complex assembly of glass plates mounted on a wooden frame, and it is fragile, bulky, heavy, and difficult to build and observe. Here, we demonstrate that we can replace the stack of photographic plates with a single reflection hologram. Experiments were successfully conducted using the digital CHIMERA holographic stereogram printing technique. This new method of holostereosynthesis will facilitate the restoration and dissemination of the historical portraits originally recorded by Louis Lumière and may also allow the creation of brand new images

Evaluation of the realism of a full-color reflection H2 analog hologram recorded on ultra-fine-grain silver-halide material

This paper presents an evaluation of the realism of a full-color reflection H2 analog hologram recorded on ultra-fine-grain silver-halide material. An H2 hologram is a transplane image that is different from the well-known Denisyuk hologram in which the final image appears fully behind the surface of the glass plate. We explain how to record this type of transplane image on the silver-halide holographic material Ultimate 04. Evaluations are performed using a mixed reality experience questionnaire. The realism of our full-color H2 hologram is successfully demonstrated and shows the potential for its integration into a diorama

The Zerotrope, a Dynamic Holographic Display: Design and Implementation

This paper presents the Zerotrope, an improved version of the classic phenakistiscope and zoetrope devices. This device is used to create a new 360-degree dynamic 3D display by the inclusion of a single ultra-realistic full-color hologram. The Zerotrope is built with a zero-degree transplane hologram mounted on a disk rotating at a constant speed. When a stroboscopic lamp synchronized with the rotation illuminates this hologram, the recorded characters, arranged radially around the center of the disk, are animated as in a stop-motion movie. The operation of the Zerotrope is successful and shows the effect of a 3D display without the need for special viewing aids

Autostereoscopic transparent display using a wedge light guide and a holographic optical element: implementation and results

We present a novel transparent autostereoscopic display consisting of laser picoprojectors, a wedge light guide, and a holographic optical element. The holographic optical element is optically recorded, and we present the recording setup, our prototype, as well as the results. Such a display can superimpose 3D data on the real world without any wearable

A transmission hologram for slitless spectrophotometry on a convergent telescope beam. 1. Focus and resolution

International audienceWe report in this paper the test of a plane holographic optical element to be used as an aberration-corrected grating for a slitless spectrograph, inserted in a convergent telescope beam. Our long-term objective is the optimization of a specific hologram to switch the auxiliary telescope imager of the Vera Rubin Observatory into an accurate slitless spectrograph, dedicated to the atmospheric transmission measurement. We present and discuss here the promising results of tests performed with prototype holograms at the CTIO |$0.9\,$|m telescope during a run of 17 nights in 2017 May–June. After their on-sky geometrical characterization, the performances of the holograms as aberration-balanced dispersive optical elements have been established by analysing spectra obtained from spectrophotometric standard stars and narrow-band emitter planetary nebulae. Thanks to their additional optical function, our holographic disperser prototypes allow us to produce significantly better focused spectra within the full visible wavelength domain |$[370,1050]\,$|nm than a regular grating, which suffers from strong defocusing and aberrations when used in similar conditions. We show that the resolution of our slitless on-axis spectrograph equipped with the hologram approaches its theoretical performance. While estimating the benefits of a hologram for the spectrum resolution, the roadmap to produce a competitive holographic element for the Vera Rubin Observatory auxiliary telescope has been established