Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD Resiquimod (R848), a tumor-targeting antibody specific for Carbonic Anhydrase IX (CAIX) and the protease-cleavable Val-Cit-PABC linker. In vitro stability analysis showed not only R848 release in the presence of the protease Cathepsin B but also under acidic conditions. The ex vivo mass spectrometry-based biodistribution data confirmed the low stability of the linker-drug connection while highlighting the selective accumulation of the IgG in tumors and its long circulatory half-life

Aging-related effects on the controlled retrieval of semantic information

The efficient use of knowledge requires semantic control processes to retrieve context-relevant information. So far, it is well established that semantic knowledge, as measured with vocabulary tests, do not decline in aging. Yet, it is still unclear if controlled retrieval -the context-driven retrieval of very specific aspects of semantic knowledge- declines in aging, following the same fate of other forms of cognitive control. Here, we tackled this issue by comparing the performance of younger and older native Italian speakers during a semantic feature verification task. To manipulate the control demands, we parametrically varied the semantic salience of the target feature for the cue concept. As compared to their young counterparts, older adults showed a worse performance (in terms of reaction times) as the salience of the target feature for the concept decreased. This result suggests that older people have relatively greater difficulties in regulating the activation within semantic representation when conditions pose high demands of controlled retrieval of semantic information

Aging-related effects on the controlled retrieval of semantic information

: The efficient use of knowledge requires semantic control processes to retrieve context-relevant information. So far, it is well-established that semantic knowledge, as measured with vocabulary tests, does not decline with aging. Yet, it is still unclear whether controlled retrieval-the context-driven retrieval of very specific aspects of semantic knowledge-deteriorates in aging, following the same fate as other forms of cognitive control. Here, we tackled this issue by comparing the performance of younger and older native Italian speakers during a semantic feature verification task. To manipulate the control demands, we parametrically varied the semantic salience of the target feature for the cue concept. As compared to their young counterparts, older adults showed worse performance (in terms of reaction times) as the salience of the target feature of the concept decreased. This result suggests that older people have relatively greater difficulties in regulating the activation within semantic representation when conditions pose high demands of controlled retrieval of semantic information. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

A Coincidence Array Demonstrator ASIC for the RD27 Muon Trigger

this document alone. Denote the input vectors as X and Y. X has n bits, Y has m. The output vector is denoted Z and has

RD-27 Note 30 July 1994 A Coincidence Array Demonstrator ASIC

this document alon

Pena, punizione e riparazione nel processo penale minorile. Uno studio valutativo sui risultati degli interventi di mediazione

Il contributo illustra i risultati di una ricerca valutativa - di outcome e di processo - sull'attivit\ue0 realizzata presso un servizio di mediazione penale minorile