Environmental and Oceanographic Conditions at the Continental Margin of the Central Basin, Northwestern Ross Sea (Antarctica) since the Last Glacial Maximum

The continental margin is a key area for studying the sedimentary processes related to the advance and retreat of the Ross Ice Shelf (Antarctica); nevertheless, much remains to be investigated. The aim of this study is to increase the knowledge of the last glacial/deglacial dynamics in the Central Basin slope–basin system using a multidisciplinary approach, including integrated sedimentological, micropaleontological and tephrochronological information. The analyses carried out on three box cores highlighted sedimentary sequences characterised by tree stratigraphic units. Collected sediments represent a time interval from 24 ka Before Present (BP) to the present time. Grain size clustering and data on the sortable silt component, together with diatom, silicoflagellate and foraminifera assemblages indicate the influence of the ice shelf calving zone (Unit 1, 24–17 ka BP), progressive receding due to Circumpolar Deep Water inflow (Unit 2, 17–10.2 ka BP) and (Unit 3, 10.2 ka BP–present) the establishment of seasonal sea ice with a strengthening of bottom currents. The dominant and persistent process is a sedimentation controlled by contour currents, which tend to modulate intensity in time and space. A primary volcanic ash layer dated back at around 22 ka BP is correlated with the explosive activity of Mount Rittmann

Last Glacial Maximum to Holocene paleoceanography of the northwestern Ross Sea inferred from sediment core geochemistry and micropaleontology at Hallett Ridge

During the Late Pleistocene Holocene, the Ross Sea Ice Shelf exhibited strong spatial variability in relation to the atmospheric and oceanographic climatic variations. Despite being thoroughly investigated, the timing of the ice sheet retreat from the outer continental shelf since the Last Glacial Maximum (LGM) still remains controversial, mainly due to a lack of sediment cores with a robust chronostratigraphy. For this reason, the recent recovery of sediments containing a continuous occurrence of calcareous foraminifera provides the important opportunity to create a reliable age model and document the early deglacial phase in particular. Here we present a multiproxy study from a sediment core collected at the Hallett Ridge (1800 m of depth), where significant occurrences of calcareous planktonic and benthic foraminifera allow us to document the first evidence of the deglaciation after the LGM at about 20.2 ka. Our results suggest that the co-occurrence of large Neogloboquadrina pachyderma tests and abundant juvenile forms reflects the beginning of open-water conditions and coverage of seasonal sea ice. Our multiproxy approach based on diatoms, silicoflagellates, carbon and oxygen stable isotopes on N. pachyderma, sediment texture, and geochemistry indicates that abrupt warming occurred at approximately 17.8 ka, followed by a period of increasing biological productivity. During the Holocene, the exclusive dominance of agglutinated benthic foraminifera suggests that dissolution was the main controlling factor on calcareous test accumulation and preservation. Diatoms and silicoflagellates show that ocean conditions were variable during the middle Holocene and the beginning of the Neoglacial period at around 4 ka. In the Neoglacial, an increase in sand content testifies to a strengthening of bottom-water currents, supported by an increase in the abundance of the tycopelagic fossil diatom Paralia sulcata transported from the coastal regions, while an increase in ice-rafted debris suggests more glacial transport by icebergs

Lithiated Short Side Chain Perfluorinated Sulfonic Ionomeric Membranes: Water Content and Conductivity

Abstract In view of possible applications as single-ion electrolyte for lithium batteries, some aspects of the lithium form of Hyflon Ion ionomer, as sulfonic short side chain (SSC) electrolyte, has been investigated. The synthesis of the ionomer and the successive membrane preparation is reported. An appropriate methodology for the direct salification of the ionomeric membrane from the SO2F form to lithium salt, using lithium hydroxide in absence of organic solvent has been found. Utilising these SSC lithium ionomer membranes and though a particular methodology for the dehydration of the lithium ion membrane in non aqueous media, it has been possible to achieve an ionic conductivity of 10-3 S/cm at room temperature [1]. Surprisingly it was observed that the membrane ionic conductivity depends on the dehydration methodologies adopted

Engraftment of HLA-matched sibling hematopoietic stem cells after immunosuppressive conditioning regimen in patients with hematologic neoplasias

Background and Objective. The main objective of this pilot study was to assess the possibility of achieving engraftment of HLA-matched sibling donor mobilized hematopoietic stem cells after immunosuppressive non-myeloablative therapy. The second objective was to verify whether high-dose therapy with autologous stem cells rescuefollowed by allografting conditioned by only an immunosuppressive regimen, can be combined in order to achieve the reduction of tumor burden after autografting and the control of residual disease with immune-mediated effects after allografting. Design and Methods.To enter the pilot study the patients had to ful\ufb01l the following criteria: advanced resistant disease, presence of an HLA matched sibling donor, no general contraindications to stem cell transplantation. Our data refers to 9 patients: Hodgkin\u2019s disease (n=4), non-Hodgkin\u2019s lymphoma (n=2), advanced chronic myelogenous leukemia (n=2) (one patient with accelerated phase Ph-negative but p190 BCR-ABL gene positive by RT-PCR and one with Ph-positive blastic phase), refractory anemia with excess of blasts t(1;3) (p36;q21) (n=1). All patients but one received the combined approach. At a median of 40days (range 30-96), after high-dose therapy and autologous stem cell engraftment, the patients were treated with immunosuppressive therapy consisting of \ufb02udarabine and cyclophosphamide (Flu-Cy protocol) and then HLA matched donor mobilized stem cells were infused into the patients. GvHD prophylaxis consisted of cyclosporin and methotrexate. Results.To date, with a median observation period of 4 months (range, 2-10), complete chimerism (100% donor cells) has been achieved in 6 patients. Three patients did not achieve complete chimerism: one patient died of progressive Hodgkin\u2019s disease when he reached 55% of donor cells, another patient is now in increasing phase of donor cell engraftment and the last patient (blastic phase-CML) was the only case who appears to have had autologous recovery. Two of the Hodgkin\u2019s disease patients, who were in partial remission after autografting, achieved complete remission after allografting and both are disease free 2 and 6 months after. Another Hodgkin\u2019s disease patient is alive at 10 months but she has progressive disease. One of the two patients with non-Hodgkin\u2019s lymphoma, who achieved partial remission after auto- grafting, obtained complete remission and he is disease free 2 months after allografting. The other patient maintains partial remission obtained after autografting. The accelerated phase-CML patient obtained hematologic and molecular remission; the RAEB patient achieved hematologic and cytogenetic remission. In two patients severe aGVHD (grade II-III) was the single major complication but neither patient died of it. Mild aGVHD was seen in another patient. in only one patient did the ANC decrease to below 1 x 109/L and in no case did platelets decrease below 20x109/L. No patients required a sterile room or any red cell or platelet transfusions. Interpretation and Conclusions.Immunosuppressive therapy with a Flu-Cy protocol allowed engraftment of HLA-matched sibling donor stem cells without procedure-related deaths; moreover, we have demonstrated that this combined procedure can be pursued in safety in a serious ill population and some of these patients achieved a complete remission. This procedure is not likely to be curative, but a fascinating step along the path to curing these diseases. Of course, the follow-up is too short to document the incidence of cGvHD