A Comparison of Human Decomposition in an Indoor and an Outdoor Environment

In the medicolegal context, forensic anthropologists assist investigators by gathering information from skeletal remains. While humans decompose in both indoor and outdoor environments, little research has been performed on the differences in the decomposition rate and process between subjects in an indoor environment and subjects in an outdoor environment. Limited accessibility to appropriate facilities for a comparison study between indoor and outdoor decomposition rates has prevented such research from being attempted. Documented through daily notes and photographs, six human subjects were observed from the fresh to the end of the bloat stages of decomposition. Three subjects were placed in an indoor structure. The other three decomposed in an outdoor environment. All subjects were compared to determine if decomposition rates differed between the indoor and outdoor subjects. From September 2004 through July 2005, six unembalmed, unautopsied human bodies were observed at the Anthropology Research Facility in Knoxville, Tennessee. The indoor structure was heated in winter and air conditioned during the fall. The air conditioner was broken throughout the spring/summer months. Decomposition rates were compared across seven variables and three stages using accumulated degree days (ADD). ADD was calculated for each subject using weather data gathered from an indoor/outdoor thermometer installed in the indoor structure. In the spring, summer, and fall months, indoor subjects decomposed faster than outdoor subjects. During the winter months, the indoor subject decomposed faster. Further research is necessary to determine the exact source of the differences in decomposition rates

The Impact of Covid-19 on Nigerian Education System

At a time when the Nigerian schools are on a temporary closure following the outbreak of the COVID-19 pandemic, this paper looked inwards and reflected on the nature of the education system and revealed its myriads of problems. The COVID-19 pandemic indeed had a huge impact on the educational system in Nigeria. It brought about the cessation of all learning activities in Nigeria except for private universities and secondary schools that swiftly switched to virtual learning platforms. It also illuminated the digital divide between the Nigerian student and his counterparts in other climes. COVID-19 pandemic outbreak also offered an opportunity for the nation to realise the poor status of its educational system. Some of the major problems that have confronted the Nigerian education system, as revealed by this paper, include poor funding, inadequate and dilapidating infrastructure, inadequate teaching facilities, poor teachers' welfare, poor research funding, poor quality of teachers, unconducive learning environment, and the like. The study recommends for the exhibition of sufficient political will by the political leadership for the transformation of the education system as well as the sustained commitment of other stakeholders such policymakers and educational administrators for the transformation of the system to give it its rightful place in our national life

SloanSpace- DSpace file transfer component

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, February 2005.Includes bibliographical references (leaf 57).This thesis demonstrates how to use Web services to integrate course management systems with digital repositories. We present a component that provides interoperation between SloanSpace, a course management system, and DSpace, a digital repository, both developed at MIT. In particular, a file transfer component was created that enables SloanSpace users to search and retrieve DSpace documents while in SloanSpace, and submit SloanSpace documents into DSpace. DSpace's web services provided the means for interaction between the systems. The architecture of the component was designed to handle not only the metadata mappings between SloanSpace and DSpace metadata, but mappings between file metadata of SloanSpace and other systems as well. Two scenarios were then created to test the effectiveness of the component. The test results demonstrate the ability of the component to decrease the amount of time spent in performing file transfers between the two systems. Most importantly, however, the component demonstrates more generally interoperation with digital repositories. It not only integrates SloanSpace with DSpace, but also allows for a more a general integration with any other system.by Genevieve T. Curvas.M.Eng

Ticks and Tick-Borne Pathogens in Domestic Animals, Wild Pigs, and Off-Host Environmental Sampling in Guam, USA

Background: Guam, a United States of America (USA) island territory in the Pacific Ocean, is known to have large populations of ticks; however, it is unclear what the risk is to wildlife and humans living on the island. Dog (Canis familiaris), cat (Felis catus), and wild pig (Sus scrofa) sentinels were examined for ticks, and environmental sampling was conducted to determine the ticks present in Guam and the prevalence of tick-borne pathogens in hosts. Methods and Results: From March 2019-November 2020, ticks were collected from environmental sampling, dogs, cats, and wild pigs. Blood samples were also taken from a subset of animals. A total of 99 ticks were collected from 27 environmental samples and all were Rhipicephalus sanguineus, the brown dog tick. Most ticks were collected during the dry season with an overall sampling success rate of 63% (95% CI: 42.4–80.6). 6,614 dogs were examined, and 12.6% (95% CI: 11.8–13.4) were infested with at least one tick. One thousand one hundred twelve cats were examined, and six (0.54%; 95% CI: 0.20–1.1) were found with ticks. Sixty-four wild pigs were examined and 17.2% (95% CI: 9.5–27.8) had ticks. In total, 1,956 ticks were collected and 97.4% of ticks were R. sanguineus. A subset of R. sanguineus were determined to be the tropical lineage. The other tick species found were Rhipicephalus microplus (0.77%), Amblyomma breviscutatum (0.77 %), and a Haemaphysalis sp. (0.51%). Blood samples from 136 dogs, four cats, and 64 wild pigs were tested using polymerase chain reaction (PCR) and DNA sequencing methods. Five different tick-borne pathogens with the following prevalences were found in dogs: Anaplasma phagocytophilum 5.9% (95% CI: 2.6–11.3); Anaplasma platys 19.1% (95% CI: 12.9–26.7); Babesia canis vogeli 8.8% (95% CI: 4.6–14.9); Ehrlichia canis 12.5% (95% CI: 7.5–19.3); Hepatozoon canis 14.7% (95% CI: 9.2–28.8). E. canis was detected in one cat, and no tick-borne pathogens were detected in wild pigs. Overall, 43.4% (95% CI: 34.9–52.1) of dogs had at least one tick-borne pathogen. Serological testing for antibodies against Ehrlichia spp. and Anaplasma spp. showed prevalences of 14.7% (95% CI: 9.2–28.8) and 31.6% (95% CI: 23.9–40), respectively. Conclusion: Four different tick species were found in Guam to include a Haemaphysalis sp., which is a previously unreported genus for Guam. Dogs with ticks have a high prevalence of tick-borne pathogens which makes them useful sentinels

Beyond a warming fingerprint: individualistic biogeographic responses to heterogeneous climate change in California.

Understanding recent biogeographic responses to climate change is fundamental for improving our predictions of likely future responses and guiding conservation planning at both local and global scales. Studies of observed biogeographic responses to 20th century climate change have principally examined effects related to ubiquitous increases in temperature - collectively termed a warming fingerprint. Although the importance of changes in other aspects of climate - particularly precipitation and water availability - is widely acknowledged from a theoretical standpoint and supported by paleontological evidence, we lack a practical understanding of how these changes interact with temperature to drive biogeographic responses. Further complicating matters, differences in life history and ecological attributes may lead species to respond differently to the same changes in climate. Here, we examine whether recent biogeographic patterns across California are consistent with a warming fingerprint. We describe how various components of climate have changed regionally in California during the 20th century and review empirical evidence of biogeographic responses to these changes, particularly elevational range shifts. Many responses to climate change do not appear to be consistent with a warming fingerprint, with downslope shifts in elevation being as common as upslope shifts across a number of taxa and many demographic and community responses being inconsistent with upslope shifts. We identify a number of potential direct and indirect mechanisms for these responses, including the influence of aspects of climate change other than temperature (e.g., the shifting seasonal balance of energy and water availability), differences in each taxon's sensitivity to climate change, trophic interactions, and land-use change. Finally, we highlight the need to move beyond a warming fingerprint in studies of biogeographic responses by considering a more multifaceted view of climate, emphasizing local-scale effects, and including a priori knowledge of relevant natural history for the taxa and regions under study

Ages and Abundances of Red Sequence Galaxies as a Function of LINER Emission Line Strength

Although the spectrum of a prototypical early-type galaxy is assumed to lack emission lines, a substantial fraction (likely as high as 30%) of nearby red sequence galaxy spectra contain emission lines with line ratios characteristic of low ionization nuclear emission-line regions (LINERs). We use spectra of ~6000 galaxies from the Sloan Digital Sky Survey (SDSS) in a narrow redshift slice (0.06 < z < 0.08) to compare the stellar populations of red sequence galaxies with and without LINER-like emission. The spectra are binned by internal velocity dispersion and by emission properties to produce high S/N stacked spectra. The recent stellar population models of R. Schiavon (2007) make it possible to measure ages, [Fe/H], and individual elemental abundance ratios [Mg/Fe], [C/Fe], [N/Fe], and [Ca/Fe] for each of the stacked spectra. We find that red sequence galaxies with strong LINER-like emission are systematically 2-3.5 Gyr (10-40%) younger than their emission-free counterparts at the same velocity dispersion. This suggests a connection between the mechanism powering the emission (whether AGN, post-AGB stars, shocks, or cooling flows) and more recent star formation in the galaxy. We find that mean stellar age and [Fe/H] increase with velocity dispersion for all galaxies. Elemental abundance [Mg/Fe] increases modestly with velocity dispersion in agreement with previous results, and [C/Fe] and [N/Fe] increase more strongly with velocity dispersion than does [Mg/Fe]. [Ca/Fe] appears to be roughly solar for all galaxies. At fixed velocity dispersion, galaxies with fainter r-band luminosities have lower [Fe/H] and older ages but similar abundance ratios compared to brighter galaxies.Comment: 25 pages, 17 figures, Accepted for publication in ApJ as of 16 July 2007; acceptance status updated, paper unchange

The cancer's Margins project: access to knowledge and Its mobilization by LGBQ/T cancer patients

Sexual and/or gender minority populations (LGBQ/T) have particular cancer risks, lower involvement in cancer screening, and experience barriers in communication with healthcare providers. All of these factors increase the probability of health decisions linked with poor outcomes that include higher levels of cancer mortality. Persistent discrimination against, and stigmatization of, LGBQ/T people is reflected in sparse medical curriculum addressing LGBQ/T communities. Marginalization makes LGBQ/T persons particularly reliant on knowledge derived from online networks and mainstream media sources. In what is likely the first nationally-funded and nation-wide study of LGBQ/T experiences of cancer, the Cancer's Margins project (www.lgbtcancer.ca) conducted face-to-face interviews with 81 sexual and/or gender minority patients diagnosed and treated for breast and/or gynecological cancer in five Canadian provinces and the San Francisco Bay area (US). With specific attention to knowledge access, sharing, and mobilization, our objective was to document and analyze complex intersectional relationships between marginalization, gender and sexuality, and cancer health decision-making and care experiences. Findings indicate that cancer care knowledge in online environments is shaped by cisnormative and heteronormative narratives. Cancer knowledge and support environments need, by contrast, to be designed by taking into account intersectionally diverse models of minority identities and communities

Methamphetamine Induces Dopamine D1 Receptor-Dependent Endoplasmic Reticulum Stress-Related Molecular Events in the Rat Striatum

Methamphetamine (METH) is an illicit toxic psychostimulant which is widely abused. Its toxic effects depend on the release of excessive levels of dopamine (DA) that activates striatal DA receptors. Inhibition of DA-mediated neurotransmission by the DA D1 receptor antagonist, SCH23390, protects against METH-induced neuronal apoptosis. The initial purpose of the present study was to investigate, using microarray analyses, the influence of SCH23390 on transcriptional responses in the rat striatum caused by a single METH injection at 2 and 4 hours after drug administration. We identified 545 out of a total of 22,227 genes as METH-responsive. These include genes which are involved in apoptotic pathways, endoplasmic reticulum (ER) stress, and in transcription regulation, among others. Of these, a total of 172 genes showed SCH23390-induced inhibition of METH-mediated changes. Among these SCH23390-responsive genes were several genes that are regulated during ER stress, namely ATF3, HSP27, Hmox1, HSP40, and CHOP/Gadd153. The secondary goal of the study was to investigate the role of DA D1 receptor stimulation on the expression of genes that participate in ER stress-mediated molecular events. We thus used quantitative PCR to confirm changes in the METH-responsive ER genes identified by the microarray analyses. We also measured the expression of these genes and of ATF4, ATF6, BiP/GRP78, and of GADD34 over a more extended time course. SCH23390 attenuated or blocked METH-induced increases in the expression of the majority of these genes. Western blot analysis revealed METH-induced increases in the expression of the antioxidant protein, Hmox1, which lasted for about 24 hours after the METH injection. Additionally, METH caused DA D1 receptor-dependent transit of the Hmox1 regulator protein, Nrf2, from cytosolic into nuclear fractions where the protein exerts its regulatory functions. When taken together, these findings indicate that SCH23390 can provide protection against neuronal apoptosis by inhibiting METH-mediated DA D1 receptor-mediated ER stress in the rat striatum. Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain