Pancreatic hydrolases in cold-induced hyperphagia of rats fed a low or high-fat diet

International audienc

Absorption intestinale d'acides aminés chez des rats recevant une alimentation mixte ou un repas protéique séparé. Variations nycthémérales et relations avec la composition de la protéine ingérée

International audienc

Modifications rapides du système lysosomal hépatique du rat en fonction de l'état nutritionnel

International audienc

Activity of several enzymes of amino acid catabolism in the liver of rats fed protein as a meal

International audienc

Détermination de la surface équivalente radar d'une cible à partir d'un modèle de mesures multistatiques en champ proche exploitant les matrices de répartition du système de mesure

CERGY PONTOISE-BU Neuville (951272102) / SudocSudocFranceF

Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial.

We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality.We conducted a multicentre, open-label interventional, stratified (centre), parallel randomised controlled trial, with a 1∶1 ratio, with two-year follow-up. Patients were aged 70 years or older treated with chemotherapy for solid tumour and at risk of malnutrition (MNA, Mini Nutritional Assessment 17-23.5). Intervention consisted of diet counselling with the aim of achieving an energy intake of 30 kCal/kg body weight/d and 1.2 g protein/kg/d, by face-to-face discussion targeting the main nutritional symptoms, compared to usual care. Interviews were performed 6 times during the chemotherapy sessions for 3 to 6 months. The primary endpoint was 1-year mortality and secondary endpoints were 2-year mortality, toxicities and chemotherapy outcomes.Between April 2007 and March 2010 we randomised 341 patients and 336 were analysed: mean (standard deviation) age of 78.0 y (4·9), 51.2% male, mean MNA 20.2 (2.1). Distribution of cancer types was similar in the two groups; the most frequent were colon (22.4%), lymphoma (14.9%), lung (10.4%), and pancreas (17.0%). Both groups increased their dietary intake, but to a larger extent with intervention (p<0.01). At the second visit, the energy target was achieved in 57 (40.4%) patients and the protein target in 66 (46.8%) with the intervention compared respectively to 13 (13.5%) and 20 (20.8%) in the controls. Death occurred during the first year in 143 patients (42.56%), without difference according to the intervention (p = 0.79). No difference in nutritional status changes was found. Response to chemotherapy was also similar between the groups.Early dietary counselling was efficient in increasing intake but had no beneficial effect on mortality or secondary outcomes. Cancer cachexia antianabolism may explain this lack of effect.ClinicalTrials.gov NCT00459589

Flowchart of participant progression through a randomized controlled trial of nutritional intervention in older patients at risk of malnutrition.

<p>Flowchart of participant progression through a randomized controlled trial of nutritional intervention in older patients at risk of malnutrition.</p

Dietary intake the day before each cycle during the chemotherapy period.

<p>Data are presented as mean and 95% CI, or proportion. Total dietary intake was analyzed with mixed models: increase of total intake at the second visit in both groups (UC+NI, P<0.0001; **UC, P = 0.02), with higher increased in UC+NI compared to UC, P<0.01.</p

Two-year mortality according to groups UC and UC+NI. N = 336.

<p>Comparisons were performed with Cox model adjusted on recruiting centres.</p

Main baseline characteristics of participants in the trial.

<p>ECOG PS: Eastern Cooperative Oncology Group performance status.</p><p>Main baseline characteristics of participants in the trial.</p