268 research outputs found
Proposed definitions of bipolar I disorder episodes and daily rapid cycling phenomena in preschoolers, school-aged children, adolescents, and adults
Proposed Definitions of Bipolar I Disorder Episodes and Daily Rapid Cycling Phenomena in Preschoolers, School-Aged Children, Adolescents, and Adults
GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype
GAD1 Single Nucleotide Polymorphism Is in Linkage Disequilibrium with a Child Bipolar I Disorder Phenotype
On Aharonov-Bohm oscillation in a ferromagnetic ring
Aharonov-Bohm effect in a ferromagnetic thin ring in diffusive regime is
theoretically studied by calculating the Cooperon and Diffuson. In addition to
the spin-orbit interaction, we include the spin-wave excitation and the spin
splitting, which are expected to be dominant sources of dephasing in
ferromagnets at low temperatures. The spin splitting turns out to kill the
spin-flip channel of Cooperon but leaves the spin-conserving channel untouched.
For the experimental confirmation of interference effect (described by
Cooperons) such as weak localization and Aharonov-Bohm oscillation with period
, we need to suppress the dominant dephasing by orbital motion. To do
this we propose experiments on a thin film or thin ring with magnetization and
external field perpendicular to the film, in which case the effective field
inside the sample is equal to the external field (magnetization does not add
up). The field is first applied strong enough to saturate the magnetization and
then carrying out the measurement down to zero field keeping the magnetization
nearly saturated, in order to avoid domain formations (negative fields may also
be investigated if the coercive field is large enough)
D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential moderating variables. Data Sources: PubMed, EMBASE, and PsycINFO were searched from inception to February 10, 2016. Reference lists of previous reviews and meta-analyses and reports of randomized clinical trials were also checked. Study Selection: Studies were eligible for inclusion if they were (1) double-blind randomized clinical trials of DCS as an augmentation strategy for exposure-based cognitive behavior therapy and (2) conducted in humans diagnosed as having specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder, or posttraumatic stress disorder. Data Extraction and Synthesis: Raw data were obtained from the authors and quality controlled. Data were ranked to ensure a consistent metric across studies (score range, 0-100). We used a 3-level multilevel model nesting repeated measures of outcomes within participants, who were nested within studies. Results: Individual participant data were obtained for 21 of 22 eligible trials, representing 1047 of 1073 eligible participants. When controlling for antidepressant use, participants receiving DCS showed greater improvement from pretreatment to posttreatment (mean difference, -3.62; 95% CI, -0.81 to -6.43; P = .01; d = -0.25) but not from pretreatment to midtreatment (mean difference, -1.66; 95% CI, -4.92 to 1.60; P = .32; d = -0.14) or from pretreatment to follow-up (mean difference, -2.98, 95% CI, -5.99 to 0.03; P = .05; d = -0.19). Additional analyses showed that participants assigned to DCS were associated with lower symptom severity than those assigned to placebo at posttreatment and at follow-up. Antidepressants did not moderate the effects of DCS. None of the prespecified patient-level or study-level moderators was associated with outcomes. Conclusions and Relevance: D-cycloserine is associated with a small augmentation effect on exposure-based therapy. This effect is not moderated by the concurrent use of antidepressants. Further research is needed to identify patient and/or therapy characteristics associated with DCS response.2018-05-0
Interdisciplinary Perspectives on Sun Safety and Skin Cancer Risk: achieving consensus
Overexposure to the sun is associated with an increased risk of melanoma and nonmelanoma skin cancer, but indications of improvements in sun protection behavior are poor. Attempts to identify emerging themes in skin cancer control have largely been driven by groups of experts from a single field. In December 2016, 19 experts from various disciplines convened for Interdisciplinary Perspectives on Skin Cancer, a 2-day meeting hosted by the National Academy of Sciences. The group discussed knowledge gaps, perspectives on sun exposure, implications for skin cancer risk and other health outcomes, and new directions. Five themes emerged from the discussion: (1) The definition of risk must be expanded, and categories for skin physiology must be refined to incorporate population diversities. (2) Risky sun exposure often co-occurs with other health-related behaviors. (3) Messages must be nuanced to target at-risk populations. (4) Persons at risk for tanning disorder must be recognized and treated. (5) Sun safety interventions must be scalable. Efficient use of technologies will be required to sharpen messages to specific populations and to integrate them within multilevel interventions. Further interdisciplinary research should address these emerging themes to build effective and sustainable approaches to large-scale behavior change
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents. We also investigated if these results generalize by estimating the effects of these obesity loci in adults and in population-based samples including both children and adults. We jointly analysed two GWAS of 2,258 individuals and followed-up the best, according to lowest p-values, 44 single nucleotide polymorphisms (SNP) from 21 genomic regions in 3,141 individuals. After this DISCOVERY step, we explored if the findings derived from the extremely obese children and adolescents (10 SNPs from 5 genomic regions) generalized to (i) the population level and (ii) to adults by genotyping another 31,182 individuals (GENERALIZATION step). Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen 8 gene; p = 1.85610 x 10(-8) in the DISCOVERY step) and one between TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase gene) and MSRA (methionine sulfoxide reductase A gene; p = 4.84 x 10(-7)), the latter finding being limited to children and adolescents as demonstrated in the GENERALIZATION step. The odds ratios for early-onset obesity were estimated at similar to 1.10 per risk allele for both loci. Interestingly, the TNKS/MSRA locus has recently been found to be associated with adult waist circumference. In summary, we have completed a meta-analysis of two GWAS which both focus on extremely obese children and adolescents and replicated our findings in a large followed-up data set. We observed that genetic variants in or near FTO, MC4R, TMEM18, SDCCAG8, and TNKS/MSRA were robustly associated with early-onset obesity. We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults
The Updated Zwicky Catalog (UZC)
The Zwicky Catalog of galaxies (ZC), with m_Zw<=15.5mag, has been the basis
for the Center for Astrophysics (CfA) redshift surveys. To date, analyses of
the ZC and redshift surveys based on it have relied on heterogeneous sets of
galaxy coordinates and redshifts. Here we correct some of the inadequacies of
previous catalogs by providing: (1) coordinates with <~2 arcsec errors for all
of the Nuzc catalog galaxies, (2) homogeneously estimated redshifts for the
majority (98%) of the data taken at the CfA (14,632 spectra), and (3) an
estimate of the remaining "blunder" rate for both the CfA redshifts and for
those compiled from the literature. For the reanalyzed CfA data we include a
calibrated, uniformly determined error and an indication of the presence of
emission lines in each spectrum. We provide redshifts for 7,257 galaxies in the
CfA2 redshift survey not previously published; for another 5,625 CfA redshifts
we list the remeasured or uniformly re-reduced value. Among our new
measurements, Nmul are members of UZC "multiplets" associated with the original
Zwicky catalog position in the coordinate range where the catalog is 98%
complete. These multiplets provide new candidates for examination of tidal
interactions among galaxies. All of the new redshifts correspond to UZC
galaxies with properties recorded in the CfA redshift compilation known as
ZCAT. About 1,000 of our new measurements were motivated either by inadequate
signal-to-noise in the original spectrum or by an ambiguous identification of
the galaxy associated with a ZCAT redshift. The redshift catalog we include
here is ~96% complete to m_Zw<=15.5, and ~98% complete (12,925 galaxies out of
a total of 13,150) for the RA(1950) ranges [20h--4h] and [8h--17h] and
DEC(1950) range [-2.5d--50d]. (abridged)Comment: 34 pp, 7 figs, PASP 1999, 111, 43
Obstetric Sphincter Injury Interacts With Diarrhea and Urgency to Increase the Risk of Fecal Incontinence in Women With Irritable Bowel Syndrome
To confirm that fecal urgency and diarrhea are independent risk factors for fecal incontinence (FI), to identify obstetrical risk factors associated with FI in women with IBS (irritable bowel syndrome), and to determine whether obstetric anal sphincter injuries interact with diarrhea or urgency to explain the occurrence of FI
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