Grain sorghum response and Palmer amaranth control with postemergence application of fluthiacet-methyl

Palmer amaranth is a problematic weed in grain sorghum production in central United States. Due to limited herbicide options available and ever increasing herbicide-resistant weed species, there is a demand for new mode-of-action herbicides for use in grain sorghum. Fluthiacet-methyl is a relatively new active ingredient that inhibits the enzyme protoporphyrinogen oxidase in target plants. Field studies were conducted at three sites in central United States in 2010 and 2011 to evaluate crop response and Palmer amaranth control with postemergence application of fluthiacet-methyl in grain sorghum. Treatments included fluthiacet-methyl at 4.8 and 7.2 g active ingredient (a.i.) haˉ¹ alone and tank-mixed with 2,4-D amine at 260 g acid equivalent (a.e.) haˉ¹ or atrazine at 840 g a.i. haˉ¹. Carfentrazone at 8.8 g a.i. haˉ¹, atrazine at 840 g haˉ¹, and a non-treated control were also included. Fluthiacet-methyl treatments caused 9–38% crop injury at 4 ± 1 days after treatment. Tank-mixing atrazine with fluthiacet-methyl seldom affected crop injury, while mixing 2,4-D with fluthiacet-methyl often reduced crop injury. Generally, injury caused by fluthiacet-methyl alone or in combination with atrazine or 2,4-D disappeared within 3 weeks after treatment. Grain yields were reduced in one trial, when 2,4-D mixed with 4.8 or 7.2 g haˉ¹ of fluthiacet-methyl caused 18% and 13% plant lodging and 24% and 14% grain yield loss, respectively. Across site-years, fluthiacet-methyl alone at 4.8 or 7.2 g haˉ¹ provided 55–95% control of Palmer amaranth. Greater Palmer amaranth control (≥75%) with fluthiacet-methyl alone was achieved when weeds were small or density was low at the time of spraying. Tank-mixing atrazine with fluthiacet-methyl increased Palmer amaranth control and sorghum yields considerably. Tank-mixing 2,4-D with fluthiacet-methyl also increased Palmer amaranth control, but to lesser extent and less consistently than with atrazine. Results indicated that fluthiacet-methyl has potential for use in grain sorghum to combat weeds resistant to acetolactase synthase-inhibitors, triazines, and synthetic auxin herbicides. Tank-mixing atrazine or 2,4-D with fluthiacet-methyl is desirable for effective Palmer amaranth control

Effects of a new herbicide (Aminocyclopyrachlor) on buffalograss and forbs in shortgrass prairie

Herbicides used to control many forb species in pastures may injure desirable native grass species. Buffalograss, a major component of shortgrass rangeland, often is injured by some growth regulator herbicides, such as 2,4-D and dicamba. Aminocyclopyrachlor (formerly known as DPX-MAT28 and herein termed ACPCR), a new synthetic auxin herbicide chemistry for control of broadleaf weeds, was investigated for injury to buffalograss and control of forbs in shortgrass prairie at varying rates of application. In the season of application, ACPCR at rates of 140 g ai haˉ¹ or less caused buffalograss injury that was either negligible or short-lived, and visual estimates of grass injury were 8% or less at the end of the growing season. At ACPCR rates of 280 g haˉ¹, more injury was evident at 3 wk after treatment (WAT) than at the end of the season if adequate precipitation was available for new leaf growth. When precipitation was lacking, evidence of injury persisted through to the end of the season when treated at the greatest rate of ACPCR. Buffalograss injury was mainly in the form of browned leaf tips, but total buffalograss dry matter yield was not different between any treatments in either year. The year after treatment, no buffalograss injury was evident from any of the herbicide rates. Final forb control was 97% or greater each year for ACPCR at the 140 and 280 g haˉ¹ rates. In this experiment, rates as low as ACPCR at 140 g haˉ¹ provided excellent forb control and maintained buffalograss productivity

Rapid Overlap Initiation Protocol Using Low Dose Buprenorphine for Opioid Use Disorder Treatment in an Outpatient Setting: A Case Series.

OBJECTIVES: Fear and risk of precipitated withdrawal are barriers for initiating buprenorphine in individuals with opioid use disorder, particularly among those using fentanyl. A buprenorphine rapid overlap initiation (ROI) protocol (also knownas rapidmicro-dosing) utilizing small, escalating doses of buprenorphine can overcome this barrier, reaching therapeutic doses in 3 to 4 days. We sought to demonstrate the feasibility of implementing a buprenorphine ROI protocol for buprenorphine initiation in the outpatient setting. METHODS: We conducted a retrospective chart review of patients prescribed an outpatient ROI protocol at the Office-based Buprenorphine Induction Clinic from October to December 2020. The ROI protocol utilizes divided doses of sublingual buprenorphine tablets and blister packaging for easier dosing. Patients were not required to stop other opioid use and were advised to follow up on day 4 of initiation. RESULTS: Twelve patients were included, of whom eleven (92%) were using fentanyl at intake. Eleven patients picked up their prescription. Seven patients returned for follow-up (58%), and all 7 completed the ROI protocol. One patient reported any withdrawal symptoms, which were mild. At 30 days, 7 patients (58%) were retained in care, and 5 (42%) were still receiving buprenorphine treatment, 4 (33%) of whom had been abstinent from nonprescribed opioid use for ≥2 weeks. CONCLUSIONS: The ROI protocol was successful in initiating buprenorphine treatment for patients in our outpatient clinic, many of whom were using fentanyl. The ROI protocol may offer a safe alternative to traditional buprenorphine initiation and warrants further study

Response of aryloxyphenoxypropionate-resistant grain sorghum to quizalofop at various rates and application timings

Citation: Abit, M. Joy M., Kassim Al-Khatib, Phillip W. Stahlman, and Patrick W. Geier. “Response of Aryloxyphenoxypropionate-Resistant Grain Sorghum to Quizalofop at Various Rates and Application Timings.” Weed Technology 26, no. 1 (March 2012): 14–18. https://doi.org/10.1614/WT-D-11-00020.1.Conventional grain sorghum is highly susceptible to POST grass control herbicides. Development of aryloxyphenoxypropionate-resistant grain sorghum could provide additional opportunities for POST herbicide grass control in grain sorghum. Field experiments were conducted at Hays and Manhattan, KS, to determine the effect of quizalofop rate and crop growth stage on injury and yield of aryloxyphenoxypropionate-resistant grain sorghum. Quizalofop was applied at 62, 124, 186, and 248 g ai haˉ¹ at sorghum heights of 8 to 10, 15 to 25, and 30 to 38 cm, which corresponded to early POST (EPOST), mid-POST (MPOST), and late POST (LPOST) application timings, respectively. Grain sorghum injury ranged from 0 to 68% at 1 wk after treatment (WAT); by 4 WAT, plants generally recovered from injury. The EPOST and MPOST applications caused 9 to 68% and 2 to 48% injury, respectively, whereas injury from LPOST was 0 to 16%, depending on rate. Crop injury from quizalofop was more prominent at rates higher than the proposed use rate in grain sorghum of 62 g ha-1. Grain yields of quizalofop treatments were similar with the non-treated treatments and that application of quizalofop at different timings did not reduce yield except when applied MPOST at the Manhattan site

Withdrawal during outpatient low dose buprenorphine initiation in people who use fentanyl: a retrospective cohort study.

BACKGROUND: Buprenorphine is an effective treatment for opioid use disorder (OUD); however, buprenorphine initiation can be complicated by withdrawal symptoms including precipitated withdrawal. There has been increasing interest in using low dose initiation (LDI) strategies to reduce this withdrawal risk. As there are limited data on withdrawal symptoms during LDI, we characterize withdrawal symptoms in people with daily fentanyl use who underwent initiation using these strategies as outpatients. METHODS: We conducted a retrospective chart review of patients with OUD using daily fentanyl who were prescribed 7-day or 4-day LDI at 2 substance use disorder treatment clinics in San Francisco. Two addiction medicine experts assessed extracted chart documentation for withdrawal severity and precipitated withdrawal, defined as acute worsening of withdrawal symptoms immediately after taking buprenorphine. A third expert adjudicated disagreements. Data were analyzed using descriptive statistics. RESULTS: There were 175 initiations in 126 patients. The mean age was 37 (SD 10 years). 71% were men, 26% women, and 2% non-binary. 21% identified as Black, 16% Latine, and 52% white. 60% were unstably housed and 75% had Medicaid insurance. Substance co-use included 74% who used amphetamines, 29% cocaine, 22% benzodiazepines, and 19% alcohol. Follow up was available for 118 (67%) initiations. There was deviation from protocol instructions in 22% of these initiations with follow up. 31% had any withdrawal, including 21% with mild symptoms, 8% moderate and 2% severe. Precipitated withdrawal occurred in 10 cases, or 8% of initiations with follow up. Of these, 7 had deviation from protocol instructions; thus, there were 3 cases with follow up (3%) in which precipitated withdrawal occurred without protocol deviation. CONCLUSIONS: Withdrawal was relatively common in our cohort but was mostly mild, and precipitated withdrawal was rare. Deviation from instructions, structural barriers, and varying fentanyl use characteristics may contribute to withdrawal. Clinicians should counsel patients who use fentanyl that mild withdrawal symptoms are likely during LDI, and there is still a low risk for precipitated withdrawal. Future studies should compare withdrawal across initiation types, seek ways to support patients in initiating buprenorphine, and qualitatively elicit patients withdrawal experiences